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Imeglimin mitigates the accumulation of dysfunctional mitochondria to restore insulin secretion and suppress apoptosis of pancreatic β-cells from db/db mice

Scientific reports, 2024-03, Vol.14 (1), p.6178-6178, Article 6178

2024

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Serotonin regulates glucose-stimulated insulin secretion from pancreatic β cells during pregnancy

Proceedings of the National Academy of Sciences - PNAS, 2013-11, Vol.110 (48), p.19420-19425

2013

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ELKS/Voltage-Dependent Ca2+ Channel-β Subunit Module Regulates Polarized Ca2+ Influx in Pancreatic β Cells

Cell reports (Cambridge), 2019-01, Vol.26 (5), p.1213-1226.e7

2019

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Acute inhibition of PI3K-PDK1-Akt pathway potentiates insulin secretion through upregulation of newcomer granule fusions in pancreatic β-cells

PloS one, 2012-10, Vol.7 (10), p.e47381

2012

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Deletion of CDKAL1 affects mitochondrial ATP generation and first-phase insulin exocytosis

PloS one, 2010-12, Vol.5 (12), p.e15553-e15553

2010

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Elevation of the post-translational modification of proteins by O-linked N-acetylglucosamine leads to deterioration of the glucose-stimulated insulin secretion in the pancreas of diabetic Goto-Kakizaki rats

Glycobiology (Oxford), 2007-02, Vol.17 (2), p.127-140

2007

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A new beta cell-specific mitophagy reporter mouse shows that metabolic stress leads to accumulation of dysfunctional mitochondria despite increased mitophagy

Diabetologia, 2023, Vol.66 (1), p.147-162

2023

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VAMP7 Regulates Autophagosome Formation by Supporting Atg9a Functions in Pancreatic β-Cells From Male Mice

Endocrinology (Philadelphia), 2018-11, Vol.159 (11), p.3674-3688

2018

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Imaging Docking and Fusion of Insulin Granules Induced by Antidiabetes Agents

Diabetes (New York, N.Y.), 2006-10, Vol.55 (10), p.2819-2825

2006

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Insulin/phosphoinositide 3-kinase pathway accelerates the glucose-induced first-phase insulin secretion through TrpV2 recruitment in pancreatic β-cells

Biochemical journal, 2010-12, Vol.432 (2), p.375-386

2010

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VAMP7 Regulates Autophagy to Maintain Mitochondrial Homeostasis and to Control Insulin Secretion in Pancreatic β-Cells

Diabetes (New York, N.Y.), 2016-06, Vol.65 (6), p.1648-1659

2016

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TIRF imaging of docking and fusion of single insulin granule motion in primary rat pancreatic beta-cells: different behaviour of granule motion between normal and Goto-Kakizaki diabetic rat beta-cells

Biochemical journal, 2004-07, Vol.381 (Pt 1), p.13-18

2004

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VAMP7 Regulates Autophagy to Maintain Mitochondrial Homeostasis and to Control Insulin Secretion in Pancreatic [Beta]-Cells

Diabetes (New York, N.Y.), 2016-06, Vol.65 (6), p.1648

2016

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Pattern of rise in subplasma membrane Ca2+ concentration determines type of fusing insulin granules in pancreatic β cells

Biochemical and biophysical research communications, 2009-07, Vol.385 (3), p.291-295

2009

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ELKS, a protein structurally related to the active zone-associated protein CAST, is expressed in pancreatic beta cells and functions in insulin exocytosis: interaction of ELKS with exocytotic machinery analyzed by total internal reflection fluorescence microscopy

Molecular biology of the cell, 2005-07, Vol.16 (7), p.3289-3300

2005

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Site of Docking and Fusion of Insulin Secretory Granules in Live MIN6 β Cells Analyzed by TAT-conjugated Anti-syntaxin 1 Antibody and Total Internal Reflection Fluorescence Microscopy

The Journal of biological chemistry, 2004-02, Vol.279 (9), p.8403-8408

2004

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Acute Inhibition of PI3K-PDK1-Akt Pathway Potentiates Insulin Secretion through Upregulation of Newcomer Granule Fusions in Pancreatic [beta]-Cells

PloS one, 2012-10, Vol.7 (10), p.e47381

2012

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DPP-4 inhibitor des-F-sitagliptin treatment increased insulin exocytosis from db/db mice β cells

Biochemical and biophysical research communications, 2011-09, Vol.412 (4), p.556-560

2011

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Imaging exocytosis of single glucagon-like peptide-1 containing granules in a murine enteroendocrine cell line with total internal reflection fluorescent microscopy

Biochemical and biophysical research communications, 2009-12, Vol.390 (1), p.16-20

2009

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DPP-4 inhibitor des-F-sitagliptin treatment increased insulin exocytosis from db/db mice {beta} cells

Biochemical and biophysical research communications, 2011-09, Vol.412 (4)

2011

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Serotonin regulates glucose-stimulated insulin secretion from pancreatic [Beta] cells during pregnancy

Proceedings of the National Academy of Sciences - PNAS, 2013-11, Vol.110 (48), p.19420

2013

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Imaging docking and fusion of insulin granules induced by antidiabetes agents : Sulfonylurea and glinide drugs preferentially mediate the fusion of newcomer, but not previously docked, insulin granules

Diabetes (New York, N.Y.), 2006-10, Vol.55 (10), p.2819-2825

2006

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Pattern of rise in subplasma membrane Ca{sup 2+} concentration determines type of fusing insulin granules in pancreatic {beta} cells

Biochemical and biophysical research communications, 2009-07, Vol.385 (3)

2009

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ELKS/Voltage-Dependent Ca 2+ Channel-β Subunit Module Regulates Polarized Ca 2+ Influx in Pancreatic β Cells

Cell reports (Cambridge), 2019-01, Vol.26 (5), p.1213

2019

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Transduction of MIN6 β Cells with TAT-Syntaxin SNARE Motif Inhibits Insulin Exocytosis in Biphasic Insulin Release in a Distinct Mechanism Analyzed by Evanescent Wave Microscopy

The Journal of biological chemistry, 2002-12, Vol.277 (52), p.50805-50811

2002

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Imeglimin mitigates the accumulation of dysfunctional mitochondria to restore insulin secretion and suppress apoptosis of pancreatic β-cells from db/db mice

Serotonin regulates glucose-stimulated insulin secretion from pancreatic β cells during pregnancy

ELKS/Voltage-Dependent Ca2+ Channel-β Subunit Module Regulates Polarized Ca2+ Influx in Pancreatic β Cells

Acute inhibition of PI3K-PDK1-Akt pathway potentiates insulin secretion through upregulation of newcomer granule fusions in pancreatic β-cells

Deletion of CDKAL1 affects mitochondrial ATP generation and first-phase insulin exocytosis

Elevation of the post-translational modification of proteins by O-linked N-acetylglucosamine leads to deterioration of the glucose-stimulated insulin secretion in the pancreas of diabetic Goto-Kakizaki rats

A new beta cell-specific mitophagy reporter mouse shows that metabolic stress leads to accumulation of dysfunctional mitochondria despite increased mitophagy

VAMP7 Regulates Autophagosome Formation by Supporting Atg9a Functions in Pancreatic β-Cells From Male Mice

Imaging Docking and Fusion of Insulin Granules Induced by Antidiabetes Agents

Insulin/phosphoinositide 3-kinase pathway accelerates the glucose-induced first-phase insulin secretion through TrpV2 recruitment in pancreatic β-cells

VAMP7 Regulates Autophagy to Maintain Mitochondrial Homeostasis and to Control Insulin Secretion in Pancreatic β-Cells

TIRF imaging of docking and fusion of single insulin granule motion in primary rat pancreatic beta-cells: different behaviour of granule motion between normal and Goto-Kakizaki diabetic rat beta-cells

VAMP7 Regulates Autophagy to Maintain Mitochondrial Homeostasis and to Control Insulin Secretion in Pancreatic [Beta]-Cells

Pattern of rise in subplasma membrane Ca2+ concentration determines type of fusing insulin granules in pancreatic β cells

ELKS, a protein structurally related to the active zone-associated protein CAST, is expressed in pancreatic beta cells and functions in insulin exocytosis: interaction of ELKS with exocytotic machinery analyzed by total internal reflection fluorescence microscopy

Site of Docking and Fusion of Insulin Secretory Granules in Live MIN6 β Cells Analyzed by TAT-conjugated Anti-syntaxin 1 Antibody and Total Internal Reflection Fluorescence Microscopy

Acute Inhibition of PI3K-PDK1-Akt Pathway Potentiates Insulin Secretion through Upregulation of Newcomer Granule Fusions in Pancreatic [beta]-Cells

DPP-4 inhibitor des-F-sitagliptin treatment increased insulin exocytosis from db/db mice β cells

Imaging exocytosis of single glucagon-like peptide-1 containing granules in a murine enteroendocrine cell line with total internal reflection fluorescent microscopy

DPP-4 inhibitor des-F-sitagliptin treatment increased insulin exocytosis from db/db mice {beta} cells

Serotonin regulates glucose-stimulated insulin secretion from pancreatic [Beta] cells during pregnancy

Imaging docking and fusion of insulin granules induced by antidiabetes agents : Sulfonylurea and glinide drugs preferentially mediate the fusion of newcomer, but not previously docked, insulin granules

Pattern of rise in subplasma membrane Ca{sup 2+} concentration determines type of fusing insulin granules in pancreatic {beta} cells

ELKS/Voltage-Dependent Ca 2+ Channel-β Subunit Module Regulates Polarized Ca 2+ Influx in Pancreatic β Cells

Transduction of MIN6 β Cells with TAT-Syntaxin SNARE Motif Inhibits Insulin Exocytosis in Biphasic Insulin Release in a Distinct Mechanism Analyzed by Evanescent Wave Microscopy

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