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Dinitroazetidines Are a Novel Class of Anticancer Agents and Hypoxia-Activated Radiation Sensitizers Developed from Highly Energetic Materials

Cancer research (Chicago, Ill.), 2012-05, Vol.72 (10), p.2600-2608

2012

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Safety and activity of RRx-001 in patients with advanced cancer: a first-in-human, open-label, dose-escalation phase 1 study

The lancet oncology, 2015-09, Vol.16 (9), p.1133-1142

2015

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Anti-αv Integrin Monoclonal Antibody Intetumumab Enhances the Efficacy of Radiation Therapy and Reduces Metastasis of Human Cancer Xenografts in Nude Rats

Cancer research (Chicago, Ill.), 2010-10, Vol.70 (19), p.7591-7599

2010

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The Development Of RRx-001, A Novel Nitric-Oxide-Mediated Epigenetically Active Anticancer Agent

Redox biology, 2015-08, Vol.5, p.422-422

2015

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The Antiangiogenic Agents SU5416 and SU6668 Increase the Antitumor Effects of Fractionated Irradiation

Radiation research, 2002-01, Vol.157 (1), p.45-51

2002

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Increased cure rate of glioblastoma using concurrent therapy with radiotherapy and arsenic trioxide

International journal of radiation oncology, biology, physics, 2004-09, Vol.60 (1), p.197-203

2004

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Sensitization of neuroendocrine prostate cancer by RRx-001

Journal of clinical oncology, 2018-02, Vol.36 (6_suppl), p.280-280

2018

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Radiation induces upregulation of cyclooxygenase-2 (COX-2) protein in PC-3 cells

International journal of radiation oncology, biology, physics, 2000-09, Vol.48 (2), p.325-328

2000

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Darbepoietin alfa potentiates the efficacy of radiation therapy in mice with corrected or uncorrected anemia

Cancer research (Chicago, Ill.), 2005, Vol.65 (1), p.284-290

2005

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Lanreotide promotes apoptosis and is not radioprotective in GH3 cells

Endocrine-related cancer, 2009-09, Vol.16 (3), p.1045-1055

2009

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NO to cancer: The complex and multifaceted role of nitric oxide and the epigenetic nitric oxide donor, RRx-001

Redox biology, 2015-12, Vol.6, p.1-8

2015

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Topical hypochlorite ameliorates NF-κB-mediated skin diseases in mice

The Journal of clinical investigation, 2013-12, Vol.123 (12), p.5361-5370

2013

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G2/M-phase arrest and death by apoptosis of HL60 cells irradiated with exponentially decreasing low-dose-rate gamma radiation

Radiation research, 1999-06, Vol.151 (6), p.659

1999

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RRx-001, A novel dinitroazetidine radiosensitizer

Investigational new drugs, 2016-06, Vol.34 (3), p.371-377

2016

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Novel nitric oxide generating compound glycidyl nitrate enhances the therapeutic efficacy of chemotherapy and radiotherapy

Biochemical and biophysical research communications, 2014-05, Vol.447 (3), p.537-542

2014

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Epigenetic effects of RRx-001: a possible unifying mechanism of anticancer activity

Oncotarget, 2015-12, Vol.6 (41), p.43172-43181

2015

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A note on improved statistical approaches to account for pseudoprogression

Cancer chemotherapy and pharmacology, 2018-03, Vol.81 (3), p.621-626

2018

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Abstract 4358: The immunomodulatory anticancer agent RRx-001 induces a vaccine-like interferon response through epigenetic induction of viral mimicry

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.4358-4358

2017

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Enhancement of murine intestinal stem cell survival after irradiation by keratinocyte growth factor

Radiation research, 1997-09, Vol.148 (3), p.248

1997

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Locally administered heparin-binding epidermal growth factor-like growth factor reduces radiation-induced oral mucositis in mice

Scientific reports, 2020-10, Vol.10 (1), p.17327, Article 17327

2020

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Rockets, radiosensitizers, and RRx-001: an origin story part I

Discovery medicine, 2016-03, Vol.21 (115), p.173-180

2016

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Nrf2 activity as a potential biomarker for the pan-epigenetic anticancer agent, RRx-001

Oncotarget, 2015-08, Vol.6 (25), p.21547-21556

2015

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RRx-001: a systemically non-toxic M2-to-M1 macrophage stimulating and prosensitizing agent in Phase II clinical trials

Expert opinion on investigational drugs, 2017-01, Vol.26 (1), p.109-119

2017

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Abstract 3515: RRx-001: A double action systemically non-toxic epigenetic agent for cancer therapy

Cancer research (Chicago, Ill.), 2015-08, Vol.75 (15_Supplement), p.3515-3515

2015

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Effects of Keratinocyte Growth Factor on the Proliferation and Radiation Survival of Human Squamous Cell Carcinoma Cell Lines In Vitro and In Vivo

International journal of radiation oncology, biology, physics, 1998, Vol.40 (1), p.177-187

1998

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Dinitroazetidines Are a Novel Class of Anticancer Agents and Hypoxia-Activated Radiation Sensitizers Developed from Highly Energetic Materials

Safety and activity of RRx-001 in patients with advanced cancer: a first-in-human, open-label, dose-escalation phase 1 study

Anti-αv Integrin Monoclonal Antibody Intetumumab Enhances the Efficacy of Radiation Therapy and Reduces Metastasis of Human Cancer Xenografts in Nude Rats

The Development Of RRx-001, A Novel Nitric-Oxide-Mediated Epigenetically Active Anticancer Agent

The Antiangiogenic Agents SU5416 and SU6668 Increase the Antitumor Effects of Fractionated Irradiation

Increased cure rate of glioblastoma using concurrent therapy with radiotherapy and arsenic trioxide

Sensitization of neuroendocrine prostate cancer by RRx-001

Radiation induces upregulation of cyclooxygenase-2 (COX-2) protein in PC-3 cells

Darbepoietin alfa potentiates the efficacy of radiation therapy in mice with corrected or uncorrected anemia

Lanreotide promotes apoptosis and is not radioprotective in GH3 cells

NO to cancer: The complex and multifaceted role of nitric oxide and the epigenetic nitric oxide donor, RRx-001

Topical hypochlorite ameliorates NF-κB-mediated skin diseases in mice

G2/M-phase arrest and death by apoptosis of HL60 cells irradiated with exponentially decreasing low-dose-rate gamma radiation

RRx-001, A novel dinitroazetidine radiosensitizer

Novel nitric oxide generating compound glycidyl nitrate enhances the therapeutic efficacy of chemotherapy and radiotherapy

Epigenetic effects of RRx-001: a possible unifying mechanism of anticancer activity

A note on improved statistical approaches to account for pseudoprogression

Abstract 4358: The immunomodulatory anticancer agent RRx-001 induces a vaccine-like interferon response through epigenetic induction of viral mimicry

Enhancement of murine intestinal stem cell survival after irradiation by keratinocyte growth factor

Locally administered heparin-binding epidermal growth factor-like growth factor reduces radiation-induced oral mucositis in mice

Rockets, radiosensitizers, and RRx-001: an origin story part I

Nrf2 activity as a potential biomarker for the pan-epigenetic anticancer agent, RRx-001

RRx-001: a systemically non-toxic M2-to-M1 macrophage stimulating and prosensitizing agent in Phase II clinical trials

Abstract 3515: RRx-001: A double action systemically non-toxic epigenetic agent for cancer therapy

Effects of Keratinocyte Growth Factor on the Proliferation and Radiation Survival of Human Squamous Cell Carcinoma Cell Lines In Vitro and In Vivo

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