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Discovery of Intestinal Targeted TGR5 Agonists for the Treatment of Type 2 Diabetes

Journal of medicinal chemistry, 2015-04, Vol.58 (8), p.3315-3328

2015

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Design, Synthesis, and Antidiabetic Activity of 4‑Phenoxynicotinamide and 4‑Phenoxypyrimidine-5-carboxamide Derivatives as Potent and Orally Efficacious TGR5 Agonists

Journal of medicinal chemistry, 2012-12, Vol.55 (23), p.10475-10489

2012

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Alisol B Alleviates Hepatocyte Lipid Accumulation and Lipotoxicity via Regulating RARα-PPARγ-CD36 Cascade and Attenuates Non-Alcoholic Steatohepatitis in Mice

Nutrients, 2022-06, Vol.14 (12), p.2411

2022

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Synthesis and antioxidant activities in polyolefin of dendritic antioxidants with hindered phenolic groups and tertiary amine

Journal of applied polymer science, 2012-06, Vol.124 (5), p.4127-4135

2012

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Discovery and Structure–Activity Relationship Study of 4-Phenoxythiazol-5-carboxamides as Highly Potent TGR5 Agonists

Chemical and Pharmaceutical Bulletin, 2016/04/01, Vol.64(4), pp.326-339

2016

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MiR-146a alleviates inflammatory bowel disease in mice through systematic regulation of multiple genetic networks

Frontiers in immunology, 2024, Vol.15, p.1366319-1366319

2024

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Design, synthesis, and pharmacological evaluation of benzamide derivatives as glucokinase activators

Bioorganic & medicinal chemistry, 2012-05, Vol.20 (9), p.2982-2991

2012

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Theoretical study on the structure and cation–anion interaction of triethylammonium chloroaluminate ionic liquid

Computational and theoretical chemistry, 2015-12, Vol.1073, p.67-74

2015

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Metabolomic Study of High-Fat Diet-Induced Obese (DIO) and DIO Plus CCl4-Induced NASH Mice and the Effect of Obeticholic Acid

Metabolites, 2021-06, Vol.11 (6), p.374

2021

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Design, synthesis and biological evaluation of a novel class of potent TGR5 agonists based on a 4-phenyl pyridine scaffold

European journal of medicinal chemistry, 2013-11, Vol.69, p.55-68

2013

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Study on the surface activity and aggregation behavior of a polyether surfactant for acidification

IOP conference series. Earth and environmental science, 2020-02, Vol.446 (2), p.22039

2020

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Design, Synthesis, and Structure-Activity Relationships of 3,4,5-Trisubstituted 4,5-Dihydro-1,2,4-oxadiazoles as TGR5 Agonists

ChemMedChem, 2013-07, Vol.8 (7), p.1210-1223

2013

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Study on the Performance of a New Type of Anionic-nonionic Surfactant

IOP conference series. Earth and environmental science, 2020-02, Vol.446 (2), p.22036

2020

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Research and Application of New Polybasic Acid

E3S web of conferences, 2020-01, Vol.165, p.5024

2020

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Synthesis and evaluation of piperidine urea derivatives as efficacious 11β-hydroxysteroid dehydrogenase type 1 inhibitors in diabetic ob/ob mice

Bioorganic & medicinal chemistry letters, 2012-04, Vol.22 (8), p.2748-2752

2012

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Discovery of Highly Potent and Selective Thyroid Hormone Receptor β Agonists for the Treatment of Nonalcoholic Steatohepatitis

Journal of medicinal chemistry, 2023-03, Vol.66 (5), p.3284-3300

2023

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Design and exploration of gut-restricted bifunctional molecule with TGR5 agonistic and DPP4 inhibitory effects for treating ulcerative colitis

European journal of medicinal chemistry, 2022-11, Vol.242, p.114697-114697, Article 114697

2022

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Aza analogues of equol: Novel ligands for estrogen receptor β

Bioorganic & medicinal chemistry, 2007-09, Vol.15 (17), p.5828-5836

2007

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TGR5 agonist ameliorates insulin resistance in skeletal muscles and improves glucose homeostasis in diabetic mice

Metabolism, clinical and experimental, 2019-10, Vol.99, p.45-56

2019

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Discovery of novel ketoxime ether derivatives with potent FXR agonistic activity, oral effectiveness and high liver/blood ratio

Bioorganic & medicinal chemistry, 2021-08, Vol.43, p.116280-116280, Article 116280

2021

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Design of G-protein-coupled bile acid receptor 1 (GPBAR1, TGR5) soft drugs with reduced gallbladder-filling effects

European journal of medicinal chemistry, 2020-10, Vol.203, p.112619-112619, Article 112619

2020

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Discovery of Highly Polar β‑Homophenylalanine Derivatives as Nonsystemic Intestine-Targeted Dipeptidyl Peptidase IV Inhibitors

Journal of medicinal chemistry, 2019-12, Vol.62 (23), p.10919-10925

2019

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Design, synthesis and structure−activity relationship studies of GPR40 agonists containing amide linker

European journal of medicinal chemistry, 2018-05, Vol.152, p.175-194

2018

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4-Benzofuranyloxynicotinamide derivatives are novel potent and orally available TGR5 agonists

European journal of medicinal chemistry, 2014-07, Vol.82, p.1-15

2014

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Re-Fracturing Technology Research and Application for Low Permeability Reservoirs in Huabei Oilfield

IOP conference series. Earth and environmental science, 2021-01, Vol.647 (1), p.12044

2021

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Discovery of Intestinal Targeted TGR5 Agonists for the Treatment of Type 2 Diabetes

Design, Synthesis, and Antidiabetic Activity of 4‑Phenoxynicotinamide and 4‑Phenoxypyrimidine-5-carboxamide Derivatives as Potent and Orally Efficacious TGR5 Agonists

Alisol B Alleviates Hepatocyte Lipid Accumulation and Lipotoxicity via Regulating RARα-PPARγ-CD36 Cascade and Attenuates Non-Alcoholic Steatohepatitis in Mice

Synthesis and antioxidant activities in polyolefin of dendritic antioxidants with hindered phenolic groups and tertiary amine

Discovery and Structure–Activity Relationship Study of 4-Phenoxythiazol-5-carboxamides as Highly Potent TGR5 Agonists

MiR-146a alleviates inflammatory bowel disease in mice through systematic regulation of multiple genetic networks

Design, synthesis, and pharmacological evaluation of benzamide derivatives as glucokinase activators

Theoretical study on the structure and cation–anion interaction of triethylammonium chloroaluminate ionic liquid

Metabolomic Study of High-Fat Diet-Induced Obese (DIO) and DIO Plus CCl4-Induced NASH Mice and the Effect of Obeticholic Acid

Design, synthesis and biological evaluation of a novel class of potent TGR5 agonists based on a 4-phenyl pyridine scaffold

Study on the surface activity and aggregation behavior of a polyether surfactant for acidification

Design, Synthesis, and Structure-Activity Relationships of 3,4,5-Trisubstituted 4,5-Dihydro-1,2,4-oxadiazoles as TGR5 Agonists

Study on the Performance of a New Type of Anionic-nonionic Surfactant

Research and Application of New Polybasic Acid

Synthesis and evaluation of piperidine urea derivatives as efficacious 11β-hydroxysteroid dehydrogenase type 1 inhibitors in diabetic ob/ob mice

Discovery of Highly Potent and Selective Thyroid Hormone Receptor β Agonists for the Treatment of Nonalcoholic Steatohepatitis

Design and exploration of gut-restricted bifunctional molecule with TGR5 agonistic and DPP4 inhibitory effects for treating ulcerative colitis

Aza analogues of equol: Novel ligands for estrogen receptor β

TGR5 agonist ameliorates insulin resistance in skeletal muscles and improves glucose homeostasis in diabetic mice

Discovery of novel ketoxime ether derivatives with potent FXR agonistic activity, oral effectiveness and high liver/blood ratio

Design of G-protein-coupled bile acid receptor 1 (GPBAR1, TGR5) soft drugs with reduced gallbladder-filling effects

Discovery of Highly Polar β‑Homophenylalanine Derivatives as Nonsystemic Intestine-Targeted Dipeptidyl Peptidase IV Inhibitors

Design, synthesis and structure−activity relationship studies of GPR40 agonists containing amide linker

4-Benzofuranyloxynicotinamide derivatives are novel potent and orally available TGR5 agonists

Re-Fracturing Technology Research and Application for Low Permeability Reservoirs in Huabei Oilfield

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