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Sigma-1 receptor: A drug target for the modulation of neuroimmune and neuroglial interactions during chronic pain

Pharmacological research, 2021-01, Vol.163, p.105339, Article 105339

2021

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Mechanistic Differences in Neuropathic Pain Modalities Revealed by Correlating Behavior with Global Expression Profiling

Cell reports (Cambridge), 2018-01, Vol.22 (5), p.1301-1312

2018

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Calcitonin Gene‐Related Peptide–Expressing Sensory Neurons and Spinal Microglial Reactivity Contribute to Pain States in Collagen‐Induced Arthritis

Arthritis & rheumatology (Hoboken, N.J.), 2015-06, Vol.67 (6), p.1668-1677

2015

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Fucoidan as a Promising Drug for Pain Treatment: Systematic Review and Meta-Analysis

Marine drugs, 2024-06, Vol.22 (7), p.290

2024

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Discovery of a σ1 receptor antagonist by combination of unbiased cell painting and thermal proteome profiling

Cell chemical biology, 2021-06, Vol.28 (6), p.848-854.e5

2021

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Efficacy and Security of Tetrodotoxin in the Treatment of Cancer-Related Pain: Systematic Review and Meta-Analysis

Marine drugs, 2023-05, Vol.21 (5), p.316

2023

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Paclitaxel antitumor effect improvement in lung cancer and prevention of the painful neuropathy using large pegylated cationic liposomes

Biomedicine & pharmacotherapy, 2021-01, Vol.133, p.111059, Article 111059

2021

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Tetrodotoxin, a Potential Drug for Neuropathic and Cancer Pain Relief?

Toxins, 2021-07, Vol.13 (7), p.483

2021

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Inflammatory pain control by blocking oxidized phospholipid-mediated TRP channel activation

Scientific reports, 2017-07, Vol.7 (1), p.5447-22, Article 5447

2017

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Genetic Inactivation and Pharmacological Blockade of Sigma-1 Receptors Prevent Paclitaxel-Induced Sensory-Nerve Mitochondrial Abnormalities and Neuropathic Pain in Mice

Molecular pain, 2014-02, Vol.10 (1), p.11-11

2014

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Antagonism by haloperidol and its metabolites of mechanical hypersensitivity induced by intraplantar capsaicin in mice: role of sigma-1 receptors

Psychopharmacologia, 2009-07, Vol.205 (1), p.21-33

2009

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Neuron-immune mechanisms contribute to pain in early stages of arthritis

Journal of neuroinflammation, 2016-04, Vol.13 (1), p.96-96, Article 96

2016

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Conformationally Restricted σ 1 Receptor Antagonists from (-)-Isopulegol

Journal of medicinal chemistry, 2023-04, Vol.66 (7), p.4999-5020

2023

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Conformationally Restricted σ1 Receptor Antagonists from (−)-Isopulegol

Journal of medicinal chemistry, 2023-04, Vol.66 (7), p.4999-5020

2023

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Sigma‐1 receptors control neuropathic pain and macrophage infiltration into the dorsal root ganglion after peripheral nerve injury

The FASEB journal, 2020-04, Vol.34 (4), p.5951-5966

2020

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The search for translational pain outcomes to refine analgesic development: Where did we come from and where are we going?

Neuroscience and biobehavioral reviews, 2020-06, Vol.113, p.238-261

2020

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Tetrahydro-3-benzazepines with fluorinated side chains as NMDA and σ1 receptor antagonists: Synthesis, receptor affinity, selectivity and antiallodynic activity

European journal of medicinal chemistry, 2019-09, Vol.177, p.47-62

2019

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Roles for CD8 + T Cells and IL-10 in the Resolution of Paclitaxel-Induced Neuropathic Pain

The Journal of neuroscience, 2017-03, Vol.37 (11), p.2803-2805

2017

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Visceral and somatic pain modalities reveal NaV1.7‐independent visceral nociceptive pathways

The Journal of physiology, 2017-04, Vol.595 (8), p.2661-2679

2017

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Urinary bladder sigma-1 receptors: A new target for cystitis treatment

Pharmacological research, 2020-05, Vol.155, p.104724, Article 104724

2020

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Sigma-1 Receptors Control Neuropathic Pain and Peripheral Neuroinflammation After Nerve Injury in Female Mice: A Transcriptomic Study

Journal of neuroimmune pharmacology, 2024-08, Vol.19 (1), p.46

2024

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Targeting immune-driven opioid analgesia by sigma-1 receptors: Opening the door to novel perspectives for the analgesic use of sigma-1 antagonists

Pharmacological research, 2018-05, Vol.131, p.224-230

2018

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NON-STEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDS) RELIEVE INFLAMMATION BUT NOT PAINFUL HYPERSENSITIVITY IN A MODEL OF RHEUMATOID ARTHRITIS

IBRO neuroscience reports, 2023-10, Vol.15, p.S689-S689

2023

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Stimulation of Cutaneous Low Threshold Mechanoreceptors in Mice After Intracolonic Capsaicin Increases Spinal c-Fos Labeling in an NKCC1-Dependent Fashion

The journal of pain, 2013, Vol.14 (1), p.57-65

2013

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Visceral and somatic pain modalities reveal Na V 1.7-independent visceral nociceptive pathways

The Journal of physiology, 2017-04, Vol.595 (8), p.2661-2679

2017

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Sigma-1 receptor: A drug target for the modulation of neuroimmune and neuroglial interactions during chronic pain

Mechanistic Differences in Neuropathic Pain Modalities Revealed by Correlating Behavior with Global Expression Profiling

Calcitonin Gene‐Related Peptide–Expressing Sensory Neurons and Spinal Microglial Reactivity Contribute to Pain States in Collagen‐Induced Arthritis

Fucoidan as a Promising Drug for Pain Treatment: Systematic Review and Meta-Analysis

Discovery of a σ1 receptor antagonist by combination of unbiased cell painting and thermal proteome profiling

Efficacy and Security of Tetrodotoxin in the Treatment of Cancer-Related Pain: Systematic Review and Meta-Analysis

Paclitaxel antitumor effect improvement in lung cancer and prevention of the painful neuropathy using large pegylated cationic liposomes

Tetrodotoxin, a Potential Drug for Neuropathic and Cancer Pain Relief?

Inflammatory pain control by blocking oxidized phospholipid-mediated TRP channel activation

Genetic Inactivation and Pharmacological Blockade of Sigma-1 Receptors Prevent Paclitaxel-Induced Sensory-Nerve Mitochondrial Abnormalities and Neuropathic Pain in Mice

Antagonism by haloperidol and its metabolites of mechanical hypersensitivity induced by intraplantar capsaicin in mice: role of sigma-1 receptors

Neuron-immune mechanisms contribute to pain in early stages of arthritis

Conformationally Restricted σ 1 Receptor Antagonists from (-)-Isopulegol

Conformationally Restricted σ1 Receptor Antagonists from (−)-Isopulegol

Sigma‐1 receptors control neuropathic pain and macrophage infiltration into the dorsal root ganglion after peripheral nerve injury

The search for translational pain outcomes to refine analgesic development: Where did we come from and where are we going?

Tetrahydro-3-benzazepines with fluorinated side chains as NMDA and σ1 receptor antagonists: Synthesis, receptor affinity, selectivity and antiallodynic activity

Roles for CD8 + T Cells and IL-10 in the Resolution of Paclitaxel-Induced Neuropathic Pain

Visceral and somatic pain modalities reveal NaV1.7‐independent visceral nociceptive pathways

Urinary bladder sigma-1 receptors: A new target for cystitis treatment

Sigma-1 Receptors Control Neuropathic Pain and Peripheral Neuroinflammation After Nerve Injury in Female Mice: A Transcriptomic Study

Targeting immune-driven opioid analgesia by sigma-1 receptors: Opening the door to novel perspectives for the analgesic use of sigma-1 antagonists

NON-STEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDS) RELIEVE INFLAMMATION BUT NOT PAINFUL HYPERSENSITIVITY IN A MODEL OF RHEUMATOID ARTHRITIS

Stimulation of Cutaneous Low Threshold Mechanoreceptors in Mice After Intracolonic Capsaicin Increases Spinal c-Fos Labeling in an NKCC1-Dependent Fashion

Visceral and somatic pain modalities reveal Na V 1.7-independent visceral nociceptive pathways

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