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Discovering novel ligands for macromolecules using X-ray crystallographic screening

Nature biotechnology, 2000-10, Vol.18 (10), p.1105-1108

2000

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A Novel Mode of Gleevec Binding Is Revealed by the Structure of Spleen Tyrosine Kinase

The Journal of biological chemistry, 2004-12, Vol.279 (53), p.55827-55832

2004

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Cysteine specific targeting of the functionally distinct peroxiredoxin and glutaredoxin proteins by the investigational disulfide BNP7787

Molecules (Basel, Switzerland), 2015-03, Vol.20 (3), p.4928-4950

2015

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Identification of Novel Binding Interactions in the Development of Potent, Selective 2-Naphthamidine Inhibitors of Urokinase. Synthesis, Structural Analysis, and SAR of N-Phenyl Amide 6-Substitution

Journal of medicinal chemistry, 2004-01, Vol.47 (2), p.303-324

2004

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Novel covalent modification of human anaplastic lymphoma kinase (ALK) and potentiation of crizotinib-mediated inhibition of ALK activity by BNP7787

OncoTargets and therapy, 2015-01, Vol.8 (default), p.375-383

2015

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Discovery of Potent Inhibitors of Dihydroneopterin Aldolase Using CrystaLEAD High-Throughput X-ray Crystallographic Screening and Structure-Directed Lead Optimization

Journal of medicinal chemistry, 2004-03, Vol.47 (7), p.1709-1718

2004

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Crystal Structure of ErmC‘, an rRNA Methyltransferase Which Mediates Antibiotic Resistance in Bacteria

Biochemistry (Easton), 1998-05, Vol.37 (20), p.7103-7112

1998

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Structure-directed discovery of potent non-peptidic inhibitors of human urokinase that access a novel binding subsite

Structure (London), 2000-05, Vol.8 (5), p.553-563

2000

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Probing Inhibitors Binding to Human Urokinase Crystals by Raman Microscopy: Implications for Compound Screening

Biochemistry (Easton), 2001-08, Vol.40 (33), p.9751-9757

2001

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Naphthamidine urokinase plasminogen activator inhibitors with improved pharmacokinetic properties

Bioorganic & medicinal chemistry letters, 2005-01, Vol.15 (1), p.93-98

2005

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A Noncleavable Retro-Binding Peptide That Spans the Substrate Binding Cleft of Serine Proteases. Atomic Structure of Nazumamide A: Human Thrombin

Journal of the American Chemical Society, 1996-07, Vol.118 (29), p.6807-6810

1996

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Structure-Based Understanding of Ligand Affinity Using Human Thrombin as a Model System

Biochemistry (Easton), 1996-07, Vol.35 (30), p.9690-9699

1996

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Atomic structures of two nitroxide spin labels complexed with human thrombin: comparison with solution studies

Journal of Protein Chemistry, 2000-02, Vol.19 (2), p.129-137

2000

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Thrombin inhibitor design: X-ray and solution studies provide a novel P1 determinant

Journal of Protein Chemistry, 2000-05, Vol.19 (4), p.327-333

2000

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Automated Crystal Mounting and Data Collection for Protein Crystallography

Structure (London), 2000-12, Vol.8 (12), p.R243-R246

2000

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Conformational similarities between one-chain and two-chain tissue plasminogen activator (t-PA): implications to the activation mechanism on one-chain t-PA

Biochemistry (Easton), 1992-04, Vol.31 (15), p.3852-3861

1992

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A glutamic acid specific serine protease utilizes a novel histidine triad in substrate binding

Biochemistry (Easton), 1993-11, Vol.32 (43), p.11469-11475

1993

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Subtle differences in active site structure between bovine and human thrombins: ESR and fluorescence studies

Thrombosis and haemostasis, 1991-01, Vol.65 (1), p.40-45

1991

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Conformational studies of two plasma proteins: Tissue plasminogen activator and alpha-thrombin

Nienaber, Vicki L

1990

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Abstract 1706: A non-canonical MiT/TFE-dependent NRF2 program is a druggable vulnerability in multiple cancer types

Cancer research (Chicago, Ill.), 2023-04, Vol.83 (7_Supplement), p.1706-1706

2023

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Novel Inhibitors of Erm Methyltransferases from NMR and Parallel Synthesis

Journal of medicinal chemistry, 1999-09, Vol.42 (19), p.3852-3859

1999

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Species Specificity of Amidine-Based Urokinase Inhibitors

Biochemistry (Easton), 2001-08, Vol.40 (31), p.9125-9131

2001

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Interaction with the S1β-pocket of urokinase: 8-heterocycle substituted and 6,8-disubstituted 2-naphthamidine urokinase inhibitors

Bioorganic & medicinal chemistry letters, 2004-06, Vol.14 (12), p.3063-3068

2004

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Interaction with the S1β-pocket of urokinase: 8-heterocycle substituted and 6,8-disubstituted 2-naphthamidine urokinase inhibitors

Bioorganic & medicinal chemistry letters, 2004-06, Vol.14 (12), p.3063-3068

2004

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Discovering novel ligands for macromolecules using X-ray crystallographic screening

A Novel Mode of Gleevec Binding Is Revealed by the Structure of Spleen Tyrosine Kinase

Cysteine specific targeting of the functionally distinct peroxiredoxin and glutaredoxin proteins by the investigational disulfide BNP7787

Identification of Novel Binding Interactions in the Development of Potent, Selective 2-Naphthamidine Inhibitors of Urokinase. Synthesis, Structural Analysis, and SAR of N-Phenyl Amide 6-Substitution

Novel covalent modification of human anaplastic lymphoma kinase (ALK) and potentiation of crizotinib-mediated inhibition of ALK activity by BNP7787

Discovery of Potent Inhibitors of Dihydroneopterin Aldolase Using CrystaLEAD High-Throughput X-ray Crystallographic Screening and Structure-Directed Lead Optimization

Crystal Structure of ErmC‘, an rRNA Methyltransferase Which Mediates Antibiotic Resistance in Bacteria

Structure-directed discovery of potent non-peptidic inhibitors of human urokinase that access a novel binding subsite

Probing Inhibitors Binding to Human Urokinase Crystals by Raman Microscopy: Implications for Compound Screening

Naphthamidine urokinase plasminogen activator inhibitors with improved pharmacokinetic properties

A Noncleavable Retro-Binding Peptide That Spans the Substrate Binding Cleft of Serine Proteases. Atomic Structure of Nazumamide A: Human Thrombin

Structure-Based Understanding of Ligand Affinity Using Human Thrombin as a Model System

Atomic structures of two nitroxide spin labels complexed with human thrombin: comparison with solution studies

Thrombin inhibitor design: X-ray and solution studies provide a novel P1 determinant

Automated Crystal Mounting and Data Collection for Protein Crystallography

Conformational similarities between one-chain and two-chain tissue plasminogen activator (t-PA): implications to the activation mechanism on one-chain t-PA

A glutamic acid specific serine protease utilizes a novel histidine triad in substrate binding

Subtle differences in active site structure between bovine and human thrombins: ESR and fluorescence studies

Conformational studies of two plasma proteins: Tissue plasminogen activator and alpha-thrombin

Abstract 1706: A non-canonical MiT/TFE-dependent NRF2 program is a druggable vulnerability in multiple cancer types

Novel Inhibitors of Erm Methyltransferases from NMR and Parallel Synthesis

Species Specificity of Amidine-Based Urokinase Inhibitors

Interaction with the S1β-pocket of urokinase: 8-heterocycle substituted and 6,8-disubstituted 2-naphthamidine urokinase inhibitors

Interaction with the S1β-pocket of urokinase: 8-heterocycle substituted and 6,8-disubstituted 2-naphthamidine urokinase inhibitors

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