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From Therapeutic Drug Monitoring to Model‐Informed Precision Dosing for Antibiotics

Clinical pharmacology and therapeutics, 2021-04, Vol.109 (4), p.928-941

2021

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Pharmacokinetic/Pharmacodynamic (PK/PD) Indices of Antibiotics Predicted by a Semimechanistic PKPD Model: a Step toward Model-Based Dose Optimization

Antimicrobial Agents and Chemotherapy, 2011-10, Vol.55 (10), p.4619-4630

2011

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Quantifying combined effects of colistin and ciprofloxacin against Escherichia coli in an in silico pharmacokinetic-pharmacodynamic model

Scientific reports, 2024-05, Vol.14 (1), p.11706-11706

2024

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The complexities of communication at hospital discharge of older patients: a qualitative study of healthcare professionals’ views

BMC health services research, 2023-11, Vol.23 (1), p.1-1211, Article 1211

2023

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Pharmacokinetic-Pharmacodynamic Model for Gentamicin and Its Adaptive Resistance with Predictions of Dosing Schedules in Newborn Infants

Antimicrobial Agents and Chemotherapy, 2012-01, Vol.56 (1), p.179-188

2012

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Population pharmacokinetics of piperacillin in febrile children receiving cancer chemotherapy: the impact of body weight and target on an optimal dosing regimen

Journal of antimicrobial chemotherapy, 2019-10, Vol.74 (10), p.2984-2993

2019

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A non-linear mixed effect model for innate immune response: In vivo kinetics of endotoxin and its induction of the cytokines tumor necrosis factor alpha and interleukin-6

PloS one, 2019-02, Vol.14 (2), p.e0211981-e0211981

2019

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Model‐based assessment of neutrophil‐mediated phagocytosis and digestion of bacteria across in vitro and in vivo studies

CPT: pharmacometrics and systems pharmacology, 2023-12, Vol.12 (12), p.1972-1987

2023

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Pharmacokinetic-pharmacodynamic modeling of antibacterial drugs

Pharmacological reviews, 2013-07, Vol.65 (3), p.1053

2013

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Population pharmacokinetics of daptomycin in patients affected by severe Gram-positive infections

International journal of antimicrobial agents, 2013-09, Vol.42 (3), p.250-255

2013

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Predicting In Vitro Antibacterial Efficacy across Experimental Designs with a Semimechanistic Pharmacokinetic-Pharmacodynamic Model

Antimicrobial Agents and Chemotherapy, 2011-04, Vol.55 (4), p.1571-1579

2011

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Semimechanistic Pharmacokinetic/Pharmacodynamic Model for Assessment of Activity of Antibacterial Agents from Time-Kill Curve Experiments

Antimicrobial Agents and Chemotherapy, 2007-01, Vol.51 (1), p.128-136

2007

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Continuous infusion of piperacillin‐tazobactam significantly improves target attainment in children with cancer and fever

Cancer reports, 2022-10, Vol.5 (10), p.e1585-n/a

2022

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Critical inhaler technique errors in Swedish patients with COPD: a cross-sectional study analysing video-recorded demonstrations

NPJ primary care respiratory medicine, 2021-02, Vol.31 (1), p.5-5, Article 5

2021

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Bayesian Forecasting Utilizing Bleeding Information to Support Dose Individualization of Factor VIII

CPT: pharmacometrics and systems pharmacology, 2019-12, Vol.8 (12), p.894-903

2019

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Pharmacodynamics of immune response biomarkers of interest for evaluation of treatment effects in bacterial infections

International journal of antimicrobial agents, 2020-09, Vol.56 (3), p.106059-106059, Article 106059

2020

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Therapeutic drug monitoring of vancomycin and meropenem: Illustration of the impact of inaccurate information in dose administration time

International journal of antimicrobial agents, 2024-01, Vol.63 (1), p.107032-107032, Article 107032

2024

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Handling interoccasion variability in model‐based dose individualization using therapeutic drug monitoring data

British journal of clinical pharmacology, 2019-06, Vol.85 (6), p.1326-1336

2019

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A novel mechanism-based pharmacokinetic–pharmacodynamic (PKPD) model describing ceftazidime/avibactam efficacy against β-lactamase-producing Gram-negative bacteria

Journal of antimicrobial chemotherapy, 2020-02, Vol.75 (2), p.400-408

2020

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Extension of Pharmacokinetic/Pharmacodynamic Time-Kill Studies To Include Lipopolysaccharide/Endotoxin Release from Escherichia coli Exposed to Cefuroxime

Antimicrobial agents and chemotherapy, 2020-03, Vol.64 (4)

2020

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Synergy of polymyxin B and minocycline against KPC-3- and OXA-48-producing Klebsiella pneumoniae in dynamic time–kill experiments: agreement with in silico predictions

Journal of antimicrobial chemotherapy, 2024-02, Vol.79 (2), p.391-402

2024

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Efficacy of Antibiotic Combinations against Multidrug-Resistant Pseudomonas aeruginosa in Automated Time-Lapse Microscopy and Static Time-Kill Experiments

Antimicrobial agents and chemotherapy, 2020-05, Vol.64 (6)

2020

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Combination of polymyxin B and minocycline against multidrug-resistant Klebsiella pneumoniae: interaction quantified by pharmacokinetic/pharmacodynamic modelling from in vitro data

International journal of antimicrobial agents, 2020-06, Vol.55 (6), p.105941, Article 105941

2020

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Predicting cytokine kinetics during sepsis; a modelling framework from a porcine sepsis model with live Escherichia coli

Cytokine (Philadelphia, Pa.), 2023-09, Vol.169, p.156296-156296, Article 156296

2023

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Relationship between factor VIII activity, bleeds and individual characteristics in severe hemophilia A patients

Haematologica (Roma), 2020-05, Vol.105 (5), p.1443

2020

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From Therapeutic Drug Monitoring to Model‐Informed Precision Dosing for Antibiotics

Pharmacokinetic/Pharmacodynamic (PK/PD) Indices of Antibiotics Predicted by a Semimechanistic PKPD Model: a Step toward Model-Based Dose Optimization

Quantifying combined effects of colistin and ciprofloxacin against Escherichia coli in an in silico pharmacokinetic-pharmacodynamic model

The complexities of communication at hospital discharge of older patients: a qualitative study of healthcare professionals’ views

Pharmacokinetic-Pharmacodynamic Model for Gentamicin and Its Adaptive Resistance with Predictions of Dosing Schedules in Newborn Infants

Population pharmacokinetics of piperacillin in febrile children receiving cancer chemotherapy: the impact of body weight and target on an optimal dosing regimen

A non-linear mixed effect model for innate immune response: In vivo kinetics of endotoxin and its induction of the cytokines tumor necrosis factor alpha and interleukin-6

Model‐based assessment of neutrophil‐mediated phagocytosis and digestion of bacteria across in vitro and in vivo studies

Pharmacokinetic-pharmacodynamic modeling of antibacterial drugs

Population pharmacokinetics of daptomycin in patients affected by severe Gram-positive infections

Predicting In Vitro Antibacterial Efficacy across Experimental Designs with a Semimechanistic Pharmacokinetic-Pharmacodynamic Model

Semimechanistic Pharmacokinetic/Pharmacodynamic Model for Assessment of Activity of Antibacterial Agents from Time-Kill Curve Experiments

Continuous infusion of piperacillin‐tazobactam significantly improves target attainment in children with cancer and fever

Critical inhaler technique errors in Swedish patients with COPD: a cross-sectional study analysing video-recorded demonstrations

Bayesian Forecasting Utilizing Bleeding Information to Support Dose Individualization of Factor VIII

Pharmacodynamics of immune response biomarkers of interest for evaluation of treatment effects in bacterial infections

Therapeutic drug monitoring of vancomycin and meropenem: Illustration of the impact of inaccurate information in dose administration time

Handling interoccasion variability in model‐based dose individualization using therapeutic drug monitoring data

A novel mechanism-based pharmacokinetic–pharmacodynamic (PKPD) model describing ceftazidime/avibactam efficacy against β-lactamase-producing Gram-negative bacteria

Extension of Pharmacokinetic/Pharmacodynamic Time-Kill Studies To Include Lipopolysaccharide/Endotoxin Release from Escherichia coli Exposed to Cefuroxime

Synergy of polymyxin B and minocycline against KPC-3- and OXA-48-producing Klebsiella pneumoniae in dynamic time–kill experiments: agreement with in silico predictions

Efficacy of Antibiotic Combinations against Multidrug-Resistant Pseudomonas aeruginosa in Automated Time-Lapse Microscopy and Static Time-Kill Experiments

Combination of polymyxin B and minocycline against multidrug-resistant Klebsiella pneumoniae: interaction quantified by pharmacokinetic/pharmacodynamic modelling from in vitro data

Predicting cytokine kinetics during sepsis; a modelling framework from a porcine sepsis model with live Escherichia coli

Relationship between factor VIII activity, bleeds and individual characteristics in severe hemophilia A patients

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