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The Akt PKB pathway: molecular target for cancer drug discovery

Oncogene, 2005-11, Vol.24 (50), p.7482-7492

2005

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Suppression of FOXO1 activity by FHL2 through SIRT1-mediated deacetylation

The EMBO journal, 2005-03, Vol.24 (5), p.1021-1032

2005

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Aurora-A Abrogation of p53 DNA Binding and Transactivation Activity by Phosphorylation of Serine 215

The Journal of biological chemistry, 2004-12, Vol.279 (50), p.52175-52182

2004

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Akt Phosphorylation and Stabilization of X-linked Inhibitor of Apoptosis Protein (XIAP)

The Journal of biological chemistry, 2004-02, Vol.279 (7), p.5405-5412

2004

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Akt/protein kinase B signaling inhibitor-2, a selective small molecule inhibitor of Akt signaling with antitumor activity in cancer cells overexpressing Akt

Cancer research (Chicago, Ill.), 2004-07, Vol.64 (13), p.4394-4399

2004

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Phosphatidylinositol 3-Kinase/Akt Pathway Regulates Tuberous Sclerosis Tumor Suppressor Complex by Phosphorylation of Tuberin

The Journal of biological chemistry, 2002-09, Vol.277 (38), p.35364-35370

2002

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Activation and Overexpression of Centrosome Kinase BTAK/Aurora-A in Human Ovarian Cancer

Clinical cancer research, 2003-04, Vol.9 (4), p.1420-1426

2003

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AKT2 inhibition of cisplatin-induced JNK/p38 and Bax activation by phosphorylation of ASK1: implication of AKT2 in chemoresistance

The Journal of biological chemistry, 2003-06, Vol.278 (26), p.23432-23440

2003

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Phosphatidylinositol-3-OH kinase (PI3K)/AKT2, activated in breast cancer, regulates and is induced by estrogen receptor α (ERα) via interaction between ERα and PI3K

Cancer research (Chicago, Ill.), 2001-08, Vol.61 (16), p.5985-5991

2001

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AKT1/PKBα Kinase Is Frequently Elevated in Human Cancers and Its Constitutive Activation Is Required for Oncogenic Transformation in NIH3T3 Cells

The American journal of pathology, 2001-08, Vol.159 (2), p.431-437

2001

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Frequent activation of AKT2 and induction of apoptosis by inhibition of phosphoinositide-3-OH kinase/akt pathway in human ovarian cancer

Oncogene, 2000-05, Vol.19 (19), p.2324-2330

2000

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Activation of Phosphatidylinositol 3-Kinase/Akt Pathway by Androgen through Interaction of p85α, Androgen Receptor, and Src

The Journal of biological chemistry, 2003-10, Vol.278 (44), p.42992-43000

2003

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Aurora-A kinase regulates telomerase activity through c-Myc in human ovarian and breast epithelial cells

Cancer research (Chicago, Ill.), 2004-01, Vol.64 (2), p.463-467

2004

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The Phosphoinositide 3-OH Kinase/AKT2 Pathway as a Critical Target for Farnesyltransferase Inhibitor-Induced Apoptosis

Molecular and Cellular Biology, 2000-01, Vol.20 (1), p.139-148

2000

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Phosphatidylinositol-3-OH kinase AKT and survivin pathways as critical targets for geranylgeranyltransferase I inhibitor-induced apoptosis

Oncogene, 2004-01, Vol.23 (3), p.706-715

2004

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Growth Suppression of Ovarian Cancer Xenografts in Nude Mice by Vitamin D Analogue EB1089

Clinical cancer research, 2005-01, Vol.11 (1), p.323-328

2005

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Vascular endothelial growth factor, platelet-derived growth factor, and insulin-like growth factor-1 promote rat aortic angiogenesis in vitro

The American journal of pathology, 1994-11, Vol.145 (5), p.1023-1029

1994

Volltextzugriff (PDF)

ESTROGEN STIMULATION OF OVARIAN SURFACE EPITHELIAL CELL PROLIFERATION

In vitro cellular & developmental biology. Animal, 2000-11, Vol.36 (10), p.657-666

2000

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Expression of insulin-like growth factor-1 receptor in human colorectal cancer

Human pathology, 1999-10, Vol.30 (10), p.1128-1133

1999

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Antagonism between PTEN/MMAC1/TEP-1 and Androgen Receptor in Growth and Apoptosis of Prostatic Cancer Cells

The Journal of biological chemistry, 2001-06, Vol.276 (23), p.20444-20450

2001

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Molecular Cloning and Characterization of the Human AKT1 Promoter Uncovers Its Up-regulation by the Src/Stat3 Pathway

The Journal of biological chemistry, 2005-11, Vol.280 (47), p.38932-38941

2005

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Vascular Endothelial Growth Factor Levels in Ovarian Cyst Fluid Correlate with Malignancy

Clinical cancer research, 1999-04, Vol.5 (4), p.823-829

1999

Volltextzugriff (PDF)

AKT2, a member of the protein kinase B family, is activated by growth factors, v-Ha-ras, and v-src through phosphatidylinositol 3-kinase in human ovarian epithelial cancer cells

Cancer research (Chicago, Ill.), 1998-07, Vol.58 (14), p.2973-2977

1998

Volltextzugriff (PDF)

Oncogenic pathways implicated in ovarian epithelial cancer

Hematology/oncology clinics of North America, 2003-08, Vol.17 (4), p.927-943

2003

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ArgBP2γ Interacts with Akt and p21-activated Kinase-1 and Promotes Cell Survival

The Journal of biological chemistry, 2005-06, Vol.280 (22), p.21483-21490

2005

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The Akt PKB pathway: molecular target for cancer drug discovery

Suppression of FOXO1 activity by FHL2 through SIRT1-mediated deacetylation

Aurora-A Abrogation of p53 DNA Binding and Transactivation Activity by Phosphorylation of Serine 215

Akt Phosphorylation and Stabilization of X-linked Inhibitor of Apoptosis Protein (XIAP)

Akt/protein kinase B signaling inhibitor-2, a selective small molecule inhibitor of Akt signaling with antitumor activity in cancer cells overexpressing Akt

Phosphatidylinositol 3-Kinase/Akt Pathway Regulates Tuberous Sclerosis Tumor Suppressor Complex by Phosphorylation of Tuberin

Activation and Overexpression of Centrosome Kinase BTAK/Aurora-A in Human Ovarian Cancer

AKT2 inhibition of cisplatin-induced JNK/p38 and Bax activation by phosphorylation of ASK1: implication of AKT2 in chemoresistance

Phosphatidylinositol-3-OH kinase (PI3K)/AKT2, activated in breast cancer, regulates and is induced by estrogen receptor α (ERα) via interaction between ERα and PI3K

AKT1/PKBα Kinase Is Frequently Elevated in Human Cancers and Its Constitutive Activation Is Required for Oncogenic Transformation in NIH3T3 Cells

Frequent activation of AKT2 and induction of apoptosis by inhibition of phosphoinositide-3-OH kinase/akt pathway in human ovarian cancer

Activation of Phosphatidylinositol 3-Kinase/Akt Pathway by Androgen through Interaction of p85α, Androgen Receptor, and Src

Aurora-A kinase regulates telomerase activity through c-Myc in human ovarian and breast epithelial cells

The Phosphoinositide 3-OH Kinase/AKT2 Pathway as a Critical Target for Farnesyltransferase Inhibitor-Induced Apoptosis

Phosphatidylinositol-3-OH kinase AKT and survivin pathways as critical targets for geranylgeranyltransferase I inhibitor-induced apoptosis

Growth Suppression of Ovarian Cancer Xenografts in Nude Mice by Vitamin D Analogue EB1089

Vascular endothelial growth factor, platelet-derived growth factor, and insulin-like growth factor-1 promote rat aortic angiogenesis in vitro

ESTROGEN STIMULATION OF OVARIAN SURFACE EPITHELIAL CELL PROLIFERATION

Expression of insulin-like growth factor-1 receptor in human colorectal cancer

Antagonism between PTEN/MMAC1/TEP-1 and Androgen Receptor in Growth and Apoptosis of Prostatic Cancer Cells

Molecular Cloning and Characterization of the Human AKT1 Promoter Uncovers Its Up-regulation by the Src/Stat3 Pathway

Vascular Endothelial Growth Factor Levels in Ovarian Cyst Fluid Correlate with Malignancy

AKT2, a member of the protein kinase B family, is activated by growth factors, v-Ha-ras, and v-src through phosphatidylinositol 3-kinase in human ovarian epithelial cancer cells

Oncogenic pathways implicated in ovarian epithelial cancer

ArgBP2γ Interacts with Akt and p21-activated Kinase-1 and Promotes Cell Survival

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