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The Role of Organic Synthesis in the Emergence and Development of Antibody–Drug Conjugates as Targeted Cancer Therapies

Angewandte Chemie International Edition, 2019-08, Vol.58 (33), p.11206-11241

International ed. in English, 2019

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Perspectives from nearly five decades of total synthesis of natural products and their analogues for biology and medicine

Natural product reports, 2020-11, Vol.37 (11), p.144-1435

2020

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Organic synthesis: the art and science of replicating the molecules of living nature and creating others like them in the laboratory

Proceedings of the Royal Society. A, Mathematical, physical, and engineering sciences, 2014-03, Vol.470 (2163), p.20130690

Nicolaou, K. C.

2014

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The art of total synthesis through cascade reactions

Chemical Society reviews, 2009-01, Vol.38 (11), p.2993-3009

2009

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Samarium Diiodide Mediated Reactions in Total Synthesis

Angewandte Chemie (International ed.), 2009-09, Vol.48 (39), p.7140-7165

2009

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Palladium-Catalyzed Cross-Coupling Reactions in Total Synthesis

Angewandte Chemie (International ed.), 2005-07, Vol.44 (29), p.4442-4489

2005

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Cascade Reactions in Total Synthesis

Angewandte Chemie (International ed.), 2006-11, Vol.45 (43), p.7134-7186

2006

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Total Syntheses of Thailanstatins A–C, Spliceostatin D, and Analogues Thereof. Stereodivergent Synthesis of Tetrasubstituted Dihydro- and Tetrahydropyrans and Design, Synthesis, Biological Evaluation, and Discovery of Potent Antitumor Agents

Journal of the American Chemical Society, 2018-07, Vol.140 (26), p.8303-8320

2018

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Metathesis Reactions in Total Synthesis

Angewandte Chemie (International ed.), 2005-07, Vol.44 (29), p.4490-4527

2005

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Addressing the Stereochemistry of Complex Organic Molecules by Density Functional Theory-NMR: Vannusal B in Retrospective

Journal of the American Chemical Society, 2011-04, Vol.133 (15), p.6072-6077

2011

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Constructing molecular complexity and diversity: total synthesis of natural products of biological and medicinal importance

Chemical Society reviews, 2012-01, Vol.41 (15), p.5185-5238

2012

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Enantioselective Dichlorination of Allylic Alcohols

Journal of the American Chemical Society, 2011-06, Vol.133 (21), p.8134-8137

2011

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Total Synthesis of the Monomeric Unit of Lomaiviticin A

Journal of the American Chemical Society, 2020-11, Vol.142 (47), p.20201-20207

2020

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Total Syntheses of Anominine and Tubingensin A

Journal of the American Chemical Society, 2012-05, Vol.134 (19), p.8078-8081

2012

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Total Synthesis and Biological Evaluation of Natural and Designed Tubulysins

Journal of the American Chemical Society, 2016-02, Vol.138 (5), p.1698-1708

2016

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Total Synthesis of Gukulenin B via Sequential Tropolone Functionalizations

Journal of the American Chemical Society, 2022-03, Vol.144 (11), p.5190-5196

2022

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12,13-Aziridinyl Epothilones. Stereoselective Synthesis of Trisubstituted Olefinic Bonds from Methyl Ketones and Heteroaromatic Phosphonates and Design, Synthesis, and Biological Evaluation of Potent Antitumor Agents

Journal of the American Chemical Society, 2017-05, Vol.139 (21), p.7318-7334

2017

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A Reverse Approach to the Total Synthesis of Halichondrin B

Journal of the American Chemical Society, 2021-06, Vol.143 (24), p.9267-9276

2021

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Continuing Saga of the Marine Polyether Biotoxins

Angewandte Chemie (International ed.), 2008-01, Vol.47 (38), p.7182-7225

2008

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Improved Total Synthesis of Tubulysins and Design, Synthesis, and Biological Evaluation of New Tubulysins with Highly Potent Cytotoxicities against Cancer Cells as Potential Payloads for Antibody–Drug Conjugates

Journal of the American Chemical Society, 2018-03, Vol.140 (10), p.3690-3711

2018

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The Emergence of the Structure of the Molecule and the Art of Its Synthesis

Angewandte Chemie (International ed.), 2013-01, Vol.52 (1), p.131-146

Nicolaou, K. C.

International ed. in English, 2013

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Total Synthesis and Biological Evaluation of Tiancimycins A and B, Yangpumicin A, and Related Anthraquinone-Fused Enediyne Antitumor Antibiotics

Journal of the American Chemical Society, 2020-02, Vol.142 (5), p.2549-2561

2020

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Recent Advances in the Chemistry and Biology of Naturally Occurring Antibiotics

Angewandte Chemie (International ed.), 2009-01, Vol.48 (4), p.660-719

2009

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How Thiostrepton Was Made in the Laboratory

Angewandte Chemie (International ed.), 2012-12, Vol.51 (50), p.12414-12436

Nicolaou, K. C.

International ed. in English, 2012

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Synthesis and Biological Evaluation of Epidithio‑, Epitetrathio‑, and bis-(Methylthio)diketopiperazines: Synthetic Methodology, Enantioselective Total Synthesis of Epicoccin G, 8,8′-epi-ent-Rostratin B, Gliotoxin, Gliotoxin G, Emethallicin E, and Haematocin and Discovery of New Antiviral and Antimalarial Agents

Journal of the American Chemical Society, 2012-10, Vol.134 (41), p.17320-17332

2012

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The Role of Organic Synthesis in the Emergence and Development of Antibody–Drug Conjugates as Targeted Cancer Therapies

Perspectives from nearly five decades of total synthesis of natural products and their analogues for biology and medicine

Organic synthesis: the art and science of replicating the molecules of living nature and creating others like them in the laboratory

The art of total synthesis through cascade reactions

Samarium Diiodide Mediated Reactions in Total Synthesis

Palladium-Catalyzed Cross-Coupling Reactions in Total Synthesis

Cascade Reactions in Total Synthesis

Total Syntheses of Thailanstatins A–C, Spliceostatin D, and Analogues Thereof. Stereodivergent Synthesis of Tetrasubstituted Dihydro- and Tetrahydropyrans and Design, Synthesis, Biological Evaluation, and Discovery of Potent Antitumor Agents

Metathesis Reactions in Total Synthesis

Addressing the Stereochemistry of Complex Organic Molecules by Density Functional Theory-NMR: Vannusal B in Retrospective

Constructing molecular complexity and diversity: total synthesis of natural products of biological and medicinal importance

Enantioselective Dichlorination of Allylic Alcohols

Total Synthesis of the Monomeric Unit of Lomaiviticin A

Total Syntheses of Anominine and Tubingensin A

Total Synthesis and Biological Evaluation of Natural and Designed Tubulysins

Total Synthesis of Gukulenin B via Sequential Tropolone Functionalizations

12,13-Aziridinyl Epothilones. Stereoselective Synthesis of Trisubstituted Olefinic Bonds from Methyl Ketones and Heteroaromatic Phosphonates and Design, Synthesis, and Biological Evaluation of Potent Antitumor Agents

A Reverse Approach to the Total Synthesis of Halichondrin B

Continuing Saga of the Marine Polyether Biotoxins

Improved Total Synthesis of Tubulysins and Design, Synthesis, and Biological Evaluation of New Tubulysins with Highly Potent Cytotoxicities against Cancer Cells as Potential Payloads for Antibody–Drug Conjugates

The Emergence of the Structure of the Molecule and the Art of Its Synthesis

Total Synthesis and Biological Evaluation of Tiancimycins A and B, Yangpumicin A, and Related Anthraquinone-Fused Enediyne Antitumor Antibiotics

Recent Advances in the Chemistry and Biology of Naturally Occurring Antibiotics

How Thiostrepton Was Made in the Laboratory

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