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MAPKAP Kinase 2-Deficient Mice Are Resistant to Collagen-Induced Arthritis

Journal of Immunology, 2006-08, Vol.177 (3), p.1913-1917

2006

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Modeling the clinical phenotype of BTK inhibition in the mature murine immune system

The Journal of immunology (1950), 2014-07, Vol.193 (1), p.185-197

2014

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Selective inhibition of BTK prevents murine lupus and antibody-mediated glomerulonephritis

The Journal of immunology (1950), 2013-11, Vol.191 (9), p.4540-4550

2013

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Imidazo[1,5- a]quinoxalines as irreversible BTK inhibitors for the treatment of rheumatoid arthritis

Bioorganic & medicinal chemistry letters, 2011-11, Vol.21 (21), p.6258-6263

2011

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mTOR — beyond transplantation

Current opinion in pharmacology, 2005-08, Vol.5 (4), p.418-423

2005

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Selective functional inhibition of JAK‐3 is sufficient for efficacy in collagen‐induced arthritis in mice

Arthritis and rheumatism, 2010-08, Vol.62 (8), p.2283-2293

2010

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The cPLA2α inhibitor efipladib decreases nociceptive responses without affecting PGE2 levels in the cerebral spinal fluid

Neuropharmacology, 2011-03, Vol.60 (4), p.633-641

2011

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Benzenesulfonamide indole inhibitors of cytosolic phospholipase A2α : Optimization of in vitro potency and rat pharmacokinetics for oral efficacy

Bioorganic & medicinal chemistry, 2008-02, Vol.16 (3), p.1345-1358

2008

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The DTH effector response and IL-2 are unaffected by cyclosporine A in autoimmune B6D2F1 mice

Cellular immunology, 2010, Vol.266 (1), p.14-23

2010

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Characterization of (2 R, 3 S)-2-({[4-(2-butynyloxy)phenyl]sulfonyl}amino)- N,3-dihydroxybutanamide, a potent and selective inhibitor of TNF-α converting enzyme

International immunopharmacology, 2004-12, Vol.4 (14), p.1845-1857

2004

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Cytosolic Phospholipase A2α–deficient Mice Are Resistant to Collagen-induced Arthritis

The Journal of experimental medicine, 2003-05, Vol.197 (10), p.1297-1302

2003

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Regulation of inflammation by collagen-binding integrins α1β1 and α2β1 in models of hypersensitivity and arthritis

The Journal of clinical investigation, 2000-03, Vol.105 (6), p.721-729

2000

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Expression of HLA-B27 in transgenic mice is controlled by gene(s) mapping between H-2D and H-2L loci

Immunogenetics (New York), 1992-02, Vol.35 (3), p.199-204

1992

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The cPLA sub(2) alpha inhibitor efipladib decreases nociceptive responses without affecting PGE sub(2) levels in the cerebral spinal fluid

Neuropharmacology, 2011-03, Vol.60 (4), p.633-641

2011

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The cPLA 2α inhibitor efipladib decreases nociceptive responses without affecting PGE 2 levels in the cerebral spinal fluid

Neuropharmacology, 2011, Vol.60 (4), p.633-641

2011

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The effect of leukotriene synthesis inhibitors in models of acute and chronic inflammation

Arthritis and rheumatism, 1996-03, Vol.39 (3), p.515-521

1996

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The novel and selective JAK3 inhibitor WYE-152038 is highly efficacious in a mouse model of rheumatoid arthritis

Cytokine (Philadelphia, Pa.), 2009-10, Vol.48 (1-2), p.78-78

2009

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Benzenesulfonamide indole inhibitors of cytosolic phospholipase A 2α: Optimization of in vitro potency and rat pharmacokinetics for oral efficacy

Bioorganic & medicinal chemistry, 2008, Vol.16 (3), p.1345-1358

2008

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Cytosolic phospholipase A2alpha-deficient mice are resistant to collagen-induced arthritis

The Journal of experimental medicine, 2003-05, Vol.197 (10), p.1297-1302

2003

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Benzenesulfonamide indole inhibitors of cytosolic phospholipase A2alpha: optimization of in vitro potency and rat pharmacokinetics for oral efficacy

Bioorganic & medicinal chemistry, 2008-02, Vol.16 (3), p.1345

2008

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Depletion of activated macrophages with a folate receptor-beta-specific antibody improves symptoms in mouse models of rheumatoid arthritis

Arthritis research & therapy, 2019-06, Vol.21 (1), p.143-14, Article 143

2019

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IL-21 receptor is critical for the development of memory B cell responses

The Journal of immunology (1950), 2011-01, Vol.186 (2), p.667-674

2011

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MAPKAP Kinase 2-Deficient Mice Are Resistant to Collagen-Induced Arthritis

Modeling the clinical phenotype of BTK inhibition in the mature murine immune system

Selective inhibition of BTK prevents murine lupus and antibody-mediated glomerulonephritis

Imidazo[1,5- a]quinoxalines as irreversible BTK inhibitors for the treatment of rheumatoid arthritis

Indole Cytosolic Phospholipase A2 α Inhibitors: Discovery and in Vitro and in Vivo Characterization of 4-{3-[5-Chloro-2-(2-{[(3,4-dichlorobenzyl)sulfonyl]amino}ethyl)-1-(diphenylmethyl)-1H-indol-3-yl]propyl}benzoic Acid, Efipladib

mTOR — beyond transplantation

Selective functional inhibition of JAK‐3 is sufficient for efficacy in collagen‐induced arthritis in mice

The cPLA2α inhibitor efipladib decreases nociceptive responses without affecting PGE2 levels in the cerebral spinal fluid

Benzenesulfonamide indole inhibitors of cytosolic phospholipase A2α : Optimization of in vitro potency and rat pharmacokinetics for oral efficacy

The DTH effector response and IL-2 are unaffected by cyclosporine A in autoimmune B6D2F1 mice

Characterization of (2 R, 3 S)-2-({[4-(2-butynyloxy)phenyl]sulfonyl}amino)- N,3-dihydroxybutanamide, a potent and selective inhibitor of TNF-α converting enzyme

Cytosolic Phospholipase A2α–deficient Mice Are Resistant to Collagen-induced Arthritis

Regulation of inflammation by collagen-binding integrins α1β1 and α2β1 in models of hypersensitivity and arthritis

Expression of HLA-B27 in transgenic mice is controlled by gene(s) mapping between H-2D and H-2L loci

The cPLA sub(2) alpha inhibitor efipladib decreases nociceptive responses without affecting PGE sub(2) levels in the cerebral spinal fluid

The cPLA 2α inhibitor efipladib decreases nociceptive responses without affecting PGE 2 levels in the cerebral spinal fluid

The effect of leukotriene synthesis inhibitors in models of acute and chronic inflammation

The novel and selective JAK3 inhibitor WYE-152038 is highly efficacious in a mouse model of rheumatoid arthritis

Indole Cytosolic Phospholipase A 2 α Inhibitors: Discovery and in Vitro and in Vivo Characterization of 4-{3-[5-Chloro-2-(2-{[(3,4-dichlorobenzyl)sulfonyl]amino}ethyl)-1-(diphenylmethyl)-1 H -indol-3-yl]propyl}benzoic Acid, Efipladib

Benzenesulfonamide indole inhibitors of cytosolic phospholipase A 2α: Optimization of in vitro potency and rat pharmacokinetics for oral efficacy

Indole Cytosolic Phospholipase A2 α Inhibitors : Discovery and in Vitro and in Vivo Characterization of 4-{3-[5-Chloro-2-(2-{[(3,4-dichlorobenzyl)sulfonyl]amino}ethyl)-l-(diphenylmethyl)-1H-indol-3-yl]propyl}benzoic Acid, Efipladib

Cytosolic phospholipase A2alpha-deficient mice are resistant to collagen-induced arthritis

Benzenesulfonamide indole inhibitors of cytosolic phospholipase A2alpha: optimization of in vitro potency and rat pharmacokinetics for oral efficacy

Depletion of activated macrophages with a folate receptor-beta-specific antibody improves symptoms in mouse models of rheumatoid arthritis

IL-21 receptor is critical for the development of memory B cell responses

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