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Canine models of inherited bleeding disorders in the development of coagulation assays, novel protein replacement and gene therapies

Journal of thrombosis and haemostasis, 2016-05, Vol.14 (5), p.894-905

2016

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Protease-Resistant Insulin-Like Growth Factor (IGF)-Binding Protein-4 Inhibits IGF-I Actions and Neointimal Expansion in a Porcine Model of Neointimal Hyperplasia

Endocrinology (Philadelphia), 2007-10, Vol.148 (10), p.5002-5010

2007

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Direct intramuscular injection with recombinant AAV vectors results in sustained expression in a dog model of hemophilia

Gene therapy, 1998, Vol.5 (1), p.40-49

1998

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Persistent expression of canine factor IX in hemophilia B canines

Gene therapy, 1999-10, Vol.6 (10), p.1695-1704

1999

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Intravenous administration of an AAV-2 vector for the expression of factor IX in mice and a dog model of hemophilia B

Gene therapy, 2004-01, Vol.11 (2), p.204-213

2004

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Pharmacokinetics of recombinant factor IX after intravenous and subcutaneous administration in dogs and cynomolgus monkeys

Thrombosis and haemostasis, 2002-05, Vol.87 (5), p.824-830

2002

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Improved kinetics of rIX‐FP, a recombinant fusion protein linking factor IX with albumin, in cynomolgus monkeys and hemophilia B dogs

Journal of thrombosis and haemostasis, 2012-08, Vol.10 (8), p.1591-1599

2012

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Pharmacokinetics and pharmacodynamics of turoctocog alfa and N8-GP in haemophilia A dogs

Haemophilia : the official journal of the World Federation of Hemophilia, 2012-11, Vol.18 (6), p.941-947

2012

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Porphyromonas gingivalis bacteremia induces coronary and aortic atherosclerosis in normocholesterolemic and hypercholesterolemic pigs

Arteriosclerosis, thrombosis, and vascular biology, 2005-07, Vol.25 (7), p.1446-1451

2005

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Haemophilic factors produced by transgenic livestock: abundance that can enable alternative therapies worldwide

Haemophilia : the official journal of the World Federation of Hemophilia, 2004-10, Vol.10 (s4), p.70-76

2004

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Sensitivity of whole blood clotting time and activated partial thromboplastin time for factor IX: relevance to gene therapy and determination of post‐transfusion elimination time of canine factor IX in hemophilia B dogs

Journal of thrombosis and haemostasis, 2012-03, Vol.10 (3), p.474-476

2012

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Protein Replacement Therapy and Gene Transfer in Canine Models of Hemophilia A, Hemophilia B, von Willebrand Disease, and Factor VII Deficiency

ILAR journal, 2009, Vol.50 (2), p.144-167

2009

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Long-term efficacy of adeno-associated virus serotypes 8 and 9 in hemophilia a dogs and mice

Human gene therapy, 2006-04, Vol.17 (4), p.427-439

2006

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Helper‐dependent adenoviral gene therapy mediates long‐term correction of the clotting defect in the canine hemophilia A model

Journal of thrombosis and haemostasis, 2006-06, Vol.4 (6), p.1218-1225

2006

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Intratracheal administration of recombinant human factor IX (BeneFix) achieves therapeutic levels in hemophilia B dogs

Thrombosis and haemostasis, 2001-03, Vol.85 (3), p.445-449

2001

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Pharmacokinetics and ex vivo whole blood clot formation of a new recombinant FVIII (N8) in haemophilia A dogs

Haemophilia : the official journal of the World Federation of Hemophilia, 2011-09, Vol.17 (5), p.e963-e968

2011

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Effect of heparin on coronary arterial patency after thrombolysis with tissue plasminogen activator in acute myocardial infarction

The American journal of cardiology, 1990-12, Vol.66 (20), p.1412-1417

1990

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Long-term correction of canine hemophilia B by gene transfer of blood coagulation factor IX mediated by adeno-associated viral vector

Nature medicine, 1999-01, Vol.5 (1), p.56-63

1999

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Preservation of Hemostatic and Structural Properties of Rehydrated Lyophilized Platelets: Potential for Long-Term Storage of Dried Platelets for Transfusion

Proceedings of the National Academy of Sciences - PNAS, 1995-01, Vol.92 (2), p.397-401

1995

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Distinguishing Migratory and Resident Canada Geese Using Stable Isotope Analysis

The Journal of wildlife management, 2000-10, Vol.64 (4), p.1084-1091

2000

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Pharmacokinetics, pharmacodynamics and safety of recombinant canine FVIIa in a study dosing one haemophilia A and one haemostatically normal dog

Haemophilia : the official journal of the World Federation of Hemophilia, 2011-11, Vol.17 (6), p.962-970

2011

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Synergistic platelet integrin signaling and factor XII activation in poly- N-acetyl glucosamine fiber-mediated hemostasis

Biomaterials, 2005-09, Vol.26 (27), p.5433-5443

2005

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Sustained phenotypic correction of canine hemophilia B after systemic administration of helper-dependent adenoviral vector

Human gene therapy, 2005-07, Vol.16 (7), p.811-820

2005

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Effect of sex, hemodynamics, body size, and other clinical variables on the corrected Thrombolysis In Myocardial Infarction frame count used as an assessment of coronary blood flow

The American heart journal, 2000-08, Vol.140 (2), p.308-314

2000

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Influence of vector dose on factor IX-specific T and B cell responses in muscle-directed gene therapy

Human gene therapy, 2002-07, Vol.13 (11), p.1281-1291

2002

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Canine models of inherited bleeding disorders in the development of coagulation assays, novel protein replacement and gene therapies

Protease-Resistant Insulin-Like Growth Factor (IGF)-Binding Protein-4 Inhibits IGF-I Actions and Neointimal Expansion in a Porcine Model of Neointimal Hyperplasia

Direct intramuscular injection with recombinant AAV vectors results in sustained expression in a dog model of hemophilia

Persistent expression of canine factor IX in hemophilia B canines

Intravenous administration of an AAV-2 vector for the expression of factor IX in mice and a dog model of hemophilia B

Pharmacokinetics of recombinant factor IX after intravenous and subcutaneous administration in dogs and cynomolgus monkeys

Improved kinetics of rIX‐FP, a recombinant fusion protein linking factor IX with albumin, in cynomolgus monkeys and hemophilia B dogs

Pharmacokinetics and pharmacodynamics of turoctocog alfa and N8-GP in haemophilia A dogs

Porphyromonas gingivalis bacteremia induces coronary and aortic atherosclerosis in normocholesterolemic and hypercholesterolemic pigs

Haemophilic factors produced by transgenic livestock: abundance that can enable alternative therapies worldwide

Sensitivity of whole blood clotting time and activated partial thromboplastin time for factor IX: relevance to gene therapy and determination of post‐transfusion elimination time of canine factor IX in hemophilia B dogs

Protein Replacement Therapy and Gene Transfer in Canine Models of Hemophilia A, Hemophilia B, von Willebrand Disease, and Factor VII Deficiency

Long-term efficacy of adeno-associated virus serotypes 8 and 9 in hemophilia a dogs and mice

Helper‐dependent adenoviral gene therapy mediates long‐term correction of the clotting defect in the canine hemophilia A model

Intratracheal administration of recombinant human factor IX (BeneFix) achieves therapeutic levels in hemophilia B dogs

Pharmacokinetics and ex vivo whole blood clot formation of a new recombinant FVIII (N8) in haemophilia A dogs

Effect of heparin on coronary arterial patency after thrombolysis with tissue plasminogen activator in acute myocardial infarction

Long-term correction of canine hemophilia B by gene transfer of blood coagulation factor IX mediated by adeno-associated viral vector

Preservation of Hemostatic and Structural Properties of Rehydrated Lyophilized Platelets: Potential for Long-Term Storage of Dried Platelets for Transfusion

Distinguishing Migratory and Resident Canada Geese Using Stable Isotope Analysis

Pharmacokinetics, pharmacodynamics and safety of recombinant canine FVIIa in a study dosing one haemophilia A and one haemostatically normal dog

Synergistic platelet integrin signaling and factor XII activation in poly- N-acetyl glucosamine fiber-mediated hemostasis

Sustained phenotypic correction of canine hemophilia B after systemic administration of helper-dependent adenoviral vector

Effect of sex, hemodynamics, body size, and other clinical variables on the corrected Thrombolysis In Myocardial Infarction frame count used as an assessment of coronary blood flow

Influence of vector dose on factor IX-specific T and B cell responses in muscle-directed gene therapy

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