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RNase H1-Dependent Antisense Oligonucleotides Are Robustly Active in Directing RNA Cleavage in Both the Cytoplasm and the Nucleus

Molecular therapy, 2017-09, Vol.25 (9), p.2075-2092

2017

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mRNA levels can be reduced by antisense oligonucleotides via no-go decay pathway

Nucleic acids research, 2019-07, Vol.47 (13), p.6900-6916

2019

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Golgi-endosome transport mediated by M6PR facilitates release of antisense oligonucleotides from endosomes

Nucleic acids research, 2020-02, Vol.48 (3), p.1372-1391

2020

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Perinuclear positioning of endosomes can affect PS-ASO activities

Nucleic acids research, 2021-12, Vol.49 (22), p.12970-12985

2021

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COPII vesicles can affect the activity of antisense oligonucleotides by facilitating the release of oligonucleotides from endocytic pathways

Nucleic acids research, 2018-11, Vol.46 (19), p.10225-10245

2018

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Site-specific replacement of phosphorothioate with alkyl phosphonate linkages enhances the therapeutic profile of gapmer ASOs by modulating interactions with cellular proteins

Nucleic acids research, 2019-06, Vol.47 (11), p.5465-5479

2019

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Legal Violence and the Limits of the Law

1, 2018

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Hsp90 protein interacts with phosphorothioate oligonucleotides containing hydrophobic 2'-modifications and enhances antisense activity

Nucleic acids research, 2016-05, Vol.44 (8), p.3892-3907

2016

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Translation can affect the antisense activity of RNase H1-dependent oligonucleotides targeting mRNAs

Nucleic acids research, 2018-01, Vol.46 (1), p.293-313

2018

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Some ASOs that bind in the coding region of mRNAs and induce RNase H1 cleavage can cause increases in the pre-mRNAs that may blunt total activity

Nucleic acids research, 2020-09, Vol.48 (17), p.9840-9858

2020

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Golgi-58K can re-localize to late endosomes upon cellular uptake of PS-ASOs and facilitates endosomal release of ASOs

Nucleic acids research, 2021-08, Vol.49 (14), p.8277-8293

2021

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IN SEARCH OF HONOURABLE CROWNS AND LEGITIMATE CONSTITUTIONS: MIKISEW CREE FIRST NATION V CANADA AND THE COLONIAL CONSTITUTION

The University of Toronto law journal, 2020-06, Vol.70 (3), p.341-375

2020

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Reconciliation and the straitjacket: A comparative analysis of the secession reference and 'R v Sparrow'

Ottawa law review, 2021-09, Vol.52 (2), p.205-255

2021

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The Combination of Mesyl-Phosphoramidate Inter-Nucleotide Linkages and 2′- O -Methyl in Selected Positions in the Antisense Oligonucleotide Enhances the Performance of RNaseH1 Active PS-ASOs

Nucleic acid therapeutics, 2022-10, Vol.32 (5), p.401-411

2022

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Podiatric Medical Resident Wellness: A Group Survey Study

Journal of the American Podiatric Medical Association, 2022-11, Vol.112 (6)

2022

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The tin ear of the court: 'Ktunaxa Nation' and the foundation of the duty to consult

Alberta law review, 2019-03, Vol.56 (3), p.729-760

2019

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Hsc70 Facilitates Mannose-6-Phosphate Receptor-Mediated Intracellular Trafficking and Enhances Endosomal Release of Phosphorothioate-Modified Antisense Oligonucleotides

Nucleic acid therapeutics, 2021-08, Vol.31 (4), p.284-297

2021

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Democratic Multiplicity: Perceiving, Enacting, and Integrating Democratic Diversity

2022

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Use of a conformational switching aptamer for rapid and specific ex vivo identification of central nervous system lymphoma in a xenograft model

PloS one, 2015-04, Vol.10 (4), p.e0123607-e0123607

2015

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The Ends of History: Questioning the Stakes of Historical Reason

1, 2013

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PCR-based approach to distinguish group A human rotavirus genotype 1 vs. genotype 2 genes

Journal of virological methods, 2013-12, Vol.194 (1-2), p.197-205

2013

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Pandémies et paradigmes de gouvernance : quels futurs pour l’État de droit au XXI e siècle?

Canadian journal of law and society, 2023-12, Vol.38 (3), p.297-298

2023

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Pandemics and Paradigms of Governance: Futures of the Rule of Law in the 21st Century

Canadian journal of law and society, 2023-12, Vol.38 (3), p.295-296

2023

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Pandémies et paradigmes de gouvernance : quels futurs pour l’État de droit au XXIe siècle?

Canadian journal of law and society, 2023, Vol.38 (3), p.297-298

2023

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A narrowing field of view: An investigation into the relationship between the principles of treaty interpretation and the conceptual framework of Canadian federalism

Osgoode Hall law journal (1960), 2019-12, Vol.56 (2), p.350-395

Nichols, Joshua Ben David

2019

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RNase H1-Dependent Antisense Oligonucleotides Are Robustly Active in Directing RNA Cleavage in Both the Cytoplasm and the Nucleus

mRNA levels can be reduced by antisense oligonucleotides via no-go decay pathway

Golgi-endosome transport mediated by M6PR facilitates release of antisense oligonucleotides from endosomes

Perinuclear positioning of endosomes can affect PS-ASO activities

COPII vesicles can affect the activity of antisense oligonucleotides by facilitating the release of oligonucleotides from endocytic pathways

Site-specific replacement of phosphorothioate with alkyl phosphonate linkages enhances the therapeutic profile of gapmer ASOs by modulating interactions with cellular proteins

Legal Violence and the Limits of the Law

Hsp90 protein interacts with phosphorothioate oligonucleotides containing hydrophobic 2'-modifications and enhances antisense activity

Translation can affect the antisense activity of RNase H1-dependent oligonucleotides targeting mRNAs

Some ASOs that bind in the coding region of mRNAs and induce RNase H1 cleavage can cause increases in the pre-mRNAs that may blunt total activity

Golgi-58K can re-localize to late endosomes upon cellular uptake of PS-ASOs and facilitates endosomal release of ASOs

IN SEARCH OF HONOURABLE CROWNS AND LEGITIMATE CONSTITUTIONS: MIKISEW CREE FIRST NATION V CANADA AND THE COLONIAL CONSTITUTION

Reconciliation and the straitjacket: A comparative analysis of the secession reference and 'R v Sparrow'

The Combination of Mesyl-Phosphoramidate Inter-Nucleotide Linkages and 2′- O -Methyl in Selected Positions in the Antisense Oligonucleotide Enhances the Performance of RNaseH1 Active PS-ASOs

Podiatric Medical Resident Wellness: A Group Survey Study

The tin ear of the court: 'Ktunaxa Nation' and the foundation of the duty to consult

Hsc70 Facilitates Mannose-6-Phosphate Receptor-Mediated Intracellular Trafficking and Enhances Endosomal Release of Phosphorothioate-Modified Antisense Oligonucleotides

Democratic Multiplicity: Perceiving, Enacting, and Integrating Democratic Diversity

Use of a conformational switching aptamer for rapid and specific ex vivo identification of central nervous system lymphoma in a xenograft model

The Ends of History: Questioning the Stakes of Historical Reason

PCR-based approach to distinguish group A human rotavirus genotype 1 vs. genotype 2 genes

Pandémies et paradigmes de gouvernance : quels futurs pour l’État de droit au XXI e siècle?

Pandemics and Paradigms of Governance: Futures of the Rule of Law in the 21st Century

Pandémies et paradigmes de gouvernance : quels futurs pour l’État de droit au XXIe siècle?

A narrowing field of view: An investigation into the relationship between the principles of treaty interpretation and the conceptual framework of Canadian federalism

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