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Perspectives for therapy of treatment‐resistant depression

British journal of pharmacology, 2022-09, Vol.179 (17), p.4181-4200

2022

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International Union of Basic and Clinical Pharmacology. CX. Classification of Receptors for 5-hydroxytryptamine; Pharmacology and Function

Pharmacological reviews, 2021-01, Vol.73 (1), p.310-520

2021

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From Receptor Selectivity to Functional Selectivity: The Rise of Biased Agonism in 5-HT1A Receptor Drug Discovery

Current topics in medicinal chemistry, 2019-01, Vol.19 (26), p.2393-2420

2019

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Towards in vivo imaging of functionally active 5-HT1A receptors in schizophrenia: concepts and challenges

Translational psychiatry, 2021-01, Vol.11 (1), p.22-22, Article 22

2021

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Anti-aggressive effects of the selective high-efficacy ‘biased’ 5-HT1A receptor agonists F15599 and F13714 in male WTG rats

Psychopharmacology, 2016-03, Vol.233 (6), p.937-947

2016

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The highly-selective 5-HT1A agonist F15599 reduces l-DOPA-induced dyskinesia without compromising anti-parkinsonian benefits in the MPTP-lesioned macaque

Neuropharmacology, 2015-10, Vol.97, p.306-311

2015

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Antinociceptive, antiallodynic and antihyperalgesic effects of the 5-HT1A receptor selective agonist, NLX-112 in mouse models of pain

Neuropharmacology, 2017-10, Vol.125, p.181-188

2017

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Distinctive in vitro signal transduction profile of NLX‐112, a potent and efficacious serotonin 5‐HT1A receptor agonist

Journal of pharmacy and pharmacology, 2017-09, Vol.69 (9), p.1178-1190

2017

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Serotonin 5‑HT1A Receptor Biased Agonists Display Differential Anxiolytic Activity in a Rat Social Interaction Model

ACS chemical neuroscience, 2019-07, Vol.10 (7), p.3101-3107

2019

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Identification of the 5-HT1A serotonin receptor as a novel therapeutic target in a C. elegans model of Machado-Joseph disease

Neurobiology of disease, 2021-05, Vol.152, p.105278-105278, Article 105278

2021

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Activity of Serotonin 5‑HT1A Receptor Biased Agonists in Rat: Anxiolytic and Antidepressant-like properties

ACS chemical neuroscience, 2018-05, Vol.9 (5), p.1040-1050

2018

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Multimodal imaging study of the 5-HT1A receptor biased agonist, NLX-112, in a model of L-DOPA-induced dyskinesia

NeuroImage clinical, 2023-01, Vol.39, p.103497-103497, Article 103497

2023

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Dissecting the contribution of 5-HT1A auto- and heteroreceptors in sucrose overconsumption in mice

Biomedicine & pharmacotherapy, 2022-04, Vol.148, p.112699-112699, Article 112699

2022

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Activation of somatodendritic 5-HT1A autoreceptors reduces the acquisition and expression of cued fear in the rat fear-potentiated startle test

Psychopharmacology, 2019-04, Vol.236 (4), p.1171-1185

2019

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Molecular Signaling Mechanisms for the Antidepressant Effects of NLX-101, a Selective Cortical 5-HT1A Receptor Biased Agonist

Pharmaceuticals (Basel, Switzerland), 2022-03, Vol.15 (3), p.337

2022

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Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. I. A multivariate analysis of the binding profiles of 14 drugs at 21 native and cloned human receptor subtypes

The Journal of pharmacology and experimental therapeutics, 2002-11, Vol.303 (2), p.791-804

2002

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Anatomically selective serotonergic type 1A and serotonergic type 2A therapies for Parkinson's disease: an approach to reducing dyskinesia without exacerbating parkinsonism?

The Journal of pharmacology and experimental therapeutics, 2011-10, Vol.339 (1), p.2-8

2011

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[18F]F13640, a 5-HT1A Receptor Radiopharmaceutical Sensitive to Brain Serotonin Fluctuations

Frontiers in neuroscience, 2021-03, Vol.15, p.622423-622423

2021

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A Postmortem Study to Compare Agonist and Antagonist 5‐HT1A Receptor‐binding Sites in Alzheimer's Disease

CNS neuroscience & therapeutics, 2014-10, Vol.20 (10), p.930-934

2014

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Serotonin 5-HT 1A Receptors and Antipsychotics - An Update in Light of New Concepts and Drugs

Current pharmaceutical design, 2015-08, Vol.21 (26), p.3725-3731

2015

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The central serotonin2B receptor: a new pharmacological target to modulate the mesoaccumbens dopaminergic pathway activity

Journal of neurochemistry, 2010-09, Vol.114 (5), p.1323-1332

2010

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NLX-101, a 5-HT1A receptor-biased agonist, improves pattern separation and stimulates neuroplasticity in aged rats

Neurobiology of aging, 2023-04, Vol.124, p.52-59

2023

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Contrasting contribution of 5-hydroxytryptamine 1A receptor activation to neurochemical profile of novel antipsychotics: frontocortical dopamine and hippocampal serotonin release in rat brain

The Journal of pharmacology and experimental therapeutics, 2005-10, Vol.315 (1), p.265-272

2005

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Novel antipsychotics activate recombinant human and native rat serotonin 5-HT1A receptors: affinity, efficacy and potential implications for treatment of schizophrenia

The international journal of neuropsychopharmacology, 2005-09, Vol.8 (3), p.341-356

2005

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High-Efficacy 5-HT1A Agonists for Antidepressant Treatment: A Renewed Opportunity

Journal of medicinal chemistry, 2007-10, Vol.50 (20), p.5024-5033

2007

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Perspectives for therapy of treatment‐resistant depression

International Union of Basic and Clinical Pharmacology. CX. Classification of Receptors for 5-hydroxytryptamine; Pharmacology and Function

From Receptor Selectivity to Functional Selectivity: The Rise of Biased Agonism in 5-HT1A Receptor Drug Discovery

Towards in vivo imaging of functionally active 5-HT1A receptors in schizophrenia: concepts and challenges

Anti-aggressive effects of the selective high-efficacy ‘biased’ 5-HT1A receptor agonists F15599 and F13714 in male WTG rats

The highly-selective 5-HT1A agonist F15599 reduces l-DOPA-induced dyskinesia without compromising anti-parkinsonian benefits in the MPTP-lesioned macaque

Antinociceptive, antiallodynic and antihyperalgesic effects of the 5-HT1A receptor selective agonist, NLX-112 in mouse models of pain

Distinctive in vitro signal transduction profile of NLX‐112, a potent and efficacious serotonin 5‐HT1A receptor agonist

Serotonin 5‑HT1A Receptor Biased Agonists Display Differential Anxiolytic Activity in a Rat Social Interaction Model

Identification of the 5-HT1A serotonin receptor as a novel therapeutic target in a C. elegans model of Machado-Joseph disease

Activity of Serotonin 5‑HT1A Receptor Biased Agonists in Rat: Anxiolytic and Antidepressant-like properties

Multimodal imaging study of the 5-HT1A receptor biased agonist, NLX-112, in a model of L-DOPA-induced dyskinesia

Dissecting the contribution of 5-HT1A auto- and heteroreceptors in sucrose overconsumption in mice

Activation of somatodendritic 5-HT1A autoreceptors reduces the acquisition and expression of cued fear in the rat fear-potentiated startle test

Molecular Signaling Mechanisms for the Antidepressant Effects of NLX-101, a Selective Cortical 5-HT1A Receptor Biased Agonist

Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. I. A multivariate analysis of the binding profiles of 14 drugs at 21 native and cloned human receptor subtypes

Anatomically selective serotonergic type 1A and serotonergic type 2A therapies for Parkinson's disease: an approach to reducing dyskinesia without exacerbating parkinsonism?

[18F]F13640, a 5-HT1A Receptor Radiopharmaceutical Sensitive to Brain Serotonin Fluctuations

A Postmortem Study to Compare Agonist and Antagonist 5‐HT1A Receptor‐binding Sites in Alzheimer's Disease

Serotonin 5-HT 1A Receptors and Antipsychotics - An Update in Light of New Concepts and Drugs

The central serotonin2B receptor: a new pharmacological target to modulate the mesoaccumbens dopaminergic pathway activity

NLX-101, a 5-HT1A receptor-biased agonist, improves pattern separation and stimulates neuroplasticity in aged rats

Contrasting contribution of 5-hydroxytryptamine 1A receptor activation to neurochemical profile of novel antipsychotics: frontocortical dopamine and hippocampal serotonin release in rat brain

Novel antipsychotics activate recombinant human and native rat serotonin 5-HT1A receptors: affinity, efficacy and potential implications for treatment of schizophrenia

High-Efficacy 5-HT1A Agonists for Antidepressant Treatment: A Renewed Opportunity

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