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The structure of dasatinib (BMS-354825) bound to activated ABL kinase domain elucidates its inhibitory activity against imatinib-resistant ABL mutants

Cancer research (Chicago, Ill.), 2006-06, Vol.66 (11), p.5790-5797

2006

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Discovery of new acylaminopyridines as GSK-3 inhibitors by a structure guided in-depth exploration of chemical space around a pyrrolopyridinone core

Bioorganic & medicinal chemistry letters, 2015-05, Vol.25 (9), p.1856-1863

2015

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Immune-modulating enzyme indoleamine 2,3-dioxygenase is effectively inhibited by targeting its apo-form

Proceedings of the National Academy of Sciences - PNAS, 2018-03, Vol.115 (13), p.3249-3254

2018

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The E. coli Signal Recognition Particle Is Required for the Insertion of a Subset of Inner Membrane Proteins

Cell, 1997-01, Vol.88 (2), p.187-196

1997

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Native mass spectrometry and gas-phase fragmentation provide rapid and in-depth topological characterization of a PROTAC ternary complex

Cell chemical biology, 2021-10, Vol.28 (10), p.1528-1538.e4

2021

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Discovery of the Selective CYP17A1 Lyase Inhibitor BMS-351 for the Treatment of Prostate Cancer

ACS medicinal chemistry letters, 2016-01, Vol.7 (1), p.40-45

2016

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Synthesis and biological evaluation of biaryl alkyl ethers as inhibitors of IDO1

Bioorganic & medicinal chemistry letters, 2023-05, Vol.88, p.129280-129280, Article 129280

2023

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Bilateral angular carpal deformity in a dog with craniomandibular osteopathy

Veterinary and comparative orthopaedics and traumatology, 2012-01, Vol.25 (2), p.149

2012

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Crystal structures of apo and inhibitor-bound TGFβR2 kinase domain: insights into TGFβR isoform selectivity

Acta crystallographica. Section D, Structural biology, 2016-05, Vol.72 (5), p.658-674

2016

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Inhibitors of human mitotic kinesin Eg5: Characterization of the 4-phenyl-tetrahydroisoquinoline lead series

Bioorganic & medicinal chemistry letters, 2006-04, Vol.16 (8), p.2095-2100

2006

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Crystal structure of microtubule affinity-regulating kinase 4 catalytic domain in complex with a pyrazolopyrimidine inhibitor

Acta crystallographica. Section F, Structural biology communications, 2016-02, Vol.72 (2), p.129-134

2016

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Using yeast surface display to engineer a soluble and crystallizable construct of hematopoietic progenitor kinase 1 (HPK1)

Acta crystallographica. Section F, Structural biology communications, 2021-01, Vol.77 (1), p.22-28

2021

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Discovery of Novel P1 Groups for Coagulation Factor VIIa Inhibition Using Fragment-Based Screening

Journal of medicinal chemistry, 2015-03, Vol.58 (6), p.2799-2808

2015

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A Mutation in the Escherichia coli secY Gene That Produces Distinct Effects on Inner Membrane Protein Insertion and Protein Export

The Journal of biological chemistry, 1998-05, Vol.273 (20), p.12451-12456

1998

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Optimization of Nicotinamides as Potent and Selective IRAK4 Inhibitors with Efficacy in a Murine Model of Psoriasis

ACS medicinal chemistry letters, 2020-07, Vol.11 (7), p.1402-1409

2020

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Development and Fit-for-Purpose Validation of a Soluble Human Programmed Death-1 Protein Assay

The AAPS journal, 2015-07, Vol.17 (4), p.976-987

2015

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Design, Synthesis, and Anti-inflammatory Properties of Orally Active 4-(Phenylamino)-pyrrolo[2,1-f][1,2,4]triazine p38α Mitogen-Activated Protein Kinase Inhibitors

Journal of medicinal chemistry, 2008-01, Vol.51 (1), p.4-16

2008

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Synthesis and SAR of pyrrolotriazine-4-one based Eg5 inhibitors

Bioorganic & medicinal chemistry letters, 2006-08, Vol.16 (15), p.3937-3942

2006

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The identification of novel p38α isoform selective kinase inhibitors having an unprecedented p38α binding mode

Bioorganic & medicinal chemistry letters, 2013-07, Vol.23 (14), p.4120-4126

2013

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The structure of multiple polypeptide domains determines the signal recognition particle targeting requirement of Escherichia coli inner membrane proteins

Journal of bacteriology, 1999-08, Vol.181 (15), p.4561-4567

1999

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Utilization of a nitrogen–sulfur nonbonding interaction in the design of new 2-aminothiazol-5-yl-pyrimidines as p38α MAP kinase inhibitors

Bioorganic & medicinal chemistry letters, 2010-10, Vol.20 (19), p.5864-5868

2010

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Development of a Model Protein Interaction Pair as a Benchmarking Tool for the Quantitative Analysis of 2-Site Protein-Protein Interactions

Journal of biomolecular techniques, 2015-12, Vol.26 (4), p.125-141

2015

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5-Amino-pyrazoles as potent and selective p38α inhibitors

Bioorganic & medicinal chemistry letters, 2010-12, Vol.20 (23), p.6886-6889

2010

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Assessing compound binding to the Eg5 motor domain using a thermal shift assay

Analytical biochemistry, 2009-09, Vol.392 (1), p.59-69

2009

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The structure of dasatinib (BMS-354825) bound to activated ABL kinase domain elucidates its inhibitory activity against imatinib-resistant ABL mutants

Discovery of new acylaminopyridines as GSK-3 inhibitors by a structure guided in-depth exploration of chemical space around a pyrrolopyridinone core

Immune-modulating enzyme indoleamine 2,3-dioxygenase is effectively inhibited by targeting its apo-form

The E. coli Signal Recognition Particle Is Required for the Insertion of a Subset of Inner Membrane Proteins

Native mass spectrometry and gas-phase fragmentation provide rapid and in-depth topological characterization of a PROTAC ternary complex

Discovery of the Selective CYP17A1 Lyase Inhibitor BMS-351 for the Treatment of Prostate Cancer

Synthesis and biological evaluation of biaryl alkyl ethers as inhibitors of IDO1

Bilateral angular carpal deformity in a dog with craniomandibular osteopathy

Crystal structures of apo and inhibitor-bound TGFβR2 kinase domain: insights into TGFβR isoform selectivity

Inhibitors of human mitotic kinesin Eg5: Characterization of the 4-phenyl-tetrahydroisoquinoline lead series

Crystal structure of microtubule affinity-regulating kinase 4 catalytic domain in complex with a pyrazolopyrimidine inhibitor

Using yeast surface display to engineer a soluble and crystallizable construct of hematopoietic progenitor kinase 1 (HPK1)

Discovery of Novel P1 Groups for Coagulation Factor VIIa Inhibition Using Fragment-Based Screening

A Mutation in the Escherichia coli secY Gene That Produces Distinct Effects on Inner Membrane Protein Insertion and Protein Export

Discovery of 4-(5-(Cyclopropylcarbamoyl)-2-methylphenylamino)-5-methyl-N-propylpyrrolo[1,2-f][1,2,4]triazine-6-carboxamide (BMS-582949), a Clinical p38α MAP Kinase Inhibitor for the Treatment of Inflammatory Diseases

Optimization of Nicotinamides as Potent and Selective IRAK4 Inhibitors with Efficacy in a Murine Model of Psoriasis

Development and Fit-for-Purpose Validation of a Soluble Human Programmed Death-1 Protein Assay

Design, Synthesis, and Anti-inflammatory Properties of Orally Active 4-(Phenylamino)-pyrrolo[2,1-f][1,2,4]triazine p38α Mitogen-Activated Protein Kinase Inhibitors

Synthesis and SAR of pyrrolotriazine-4-one based Eg5 inhibitors

The identification of novel p38α isoform selective kinase inhibitors having an unprecedented p38α binding mode

The structure of multiple polypeptide domains determines the signal recognition particle targeting requirement of Escherichia coli inner membrane proteins

Utilization of a nitrogen–sulfur nonbonding interaction in the design of new 2-aminothiazol-5-yl-pyrimidines as p38α MAP kinase inhibitors

Development of a Model Protein Interaction Pair as a Benchmarking Tool for the Quantitative Analysis of 2-Site Protein-Protein Interactions

5-Amino-pyrazoles as potent and selective p38α inhibitors

Assessing compound binding to the Eg5 motor domain using a thermal shift assay

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