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The structural basis for specificity in lipoxygenase catalysis

Protein science, 2015-03, Vol.24 (3), p.298-309

2015

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Untangling the web of 5-lipoxygenase-derived products from a molecular and structural perspective: The battle between pro- and anti-inflammatory lipid mediators

Biochemical pharmacology, 2021-11, Vol.193, p.114759-114759, Article 114759

2021

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Chloride to the rescue

The Journal of biological chemistry, 2019-07, Vol.294 (30), p.11402-11403

Newcomer, Marcia E.

2019

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Structural and mechanistic insights into 5-lipoxygenase inhibition by natural products

Nature chemical biology, 2020-07, Vol.16 (7), p.783

2020

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The Structure of Human 5-Lipoxygenase

Science (American Association for the Advancement of Science), 2011-01, Vol.331 (6014), p.217-219

2011

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Structural basis of antifreeze activity of a bacterial multi-domain antifreeze protein

PloS one, 2017-11, Vol.12 (11), p.e0187169-e0187169

2017

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Structures of Leukotriene Biosynthetic Enzymes and Development of New Therapeutics

Annual review of pharmacology and toxicology, 2023-01, Vol.63, p.407

2023

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Conversion of human 5‐lipoxygenase to a 15‐lipoxygenase by a point mutation to mimic phosphorylation at Serine‐663

The FASEB journal, 2012-08, Vol.26 (8), p.3222-3229

2012

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Identification of the Substrate Access Portal of 5‑Lipoxygenase

Biochemistry (Easton), 2015-10, Vol.54 (41), p.6333-6342

2015

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The Structure of Human 15-Lipoxygenase-2 with a Substrate Mimic

The Journal of biological chemistry, 2014-03, Vol.289 (12), p.8562-8569

2014

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5‐Lipoxygenase‐activating protein rescues activity of 5‐lipoxygenase mutations that delay nuclear membrane association and disrupt product formation

The FASEB journal, 2016-05, Vol.30 (5), p.1892-1900

2016

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Identification and optimization of soluble epoxide hydrolase inhibitors with dual potency towards fatty acid amide hydrolase

Bioorganic & medicinal chemistry letters, 2018-02, Vol.28 (4), p.762-768

2018

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Cannabidiol acts as molecular switch in innate immune cells to promote the biosynthesis of inflammation-resolving lipid mediators

Cell chemical biology, 2023-12, Vol.30 (12), p.1508-1524.e7

2023

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Membrane-dependent Activities of Human 15-LOX-2 and Its Murine Counterpart: IMPLICATIONS FOR MURINE MODELS OF ATHEROSCLEROSIS

The Journal of biological chemistry, 2016-09, Vol.291 (37), p.19413-19424

2016

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Optimized Inhibitors of Soluble Epoxide Hydrolase Improve in Vitro Target Residence Time and in Vivo Efficacy

Journal of medicinal chemistry, 2014-08, Vol.57 (16), p.7016-7030

2014

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Helical remodeling augments 5-lipoxygenase activity in the synthesis of proinflammatory mediators

The Journal of biological chemistry, 2022-09, Vol.298 (9), p.102282-102282, Article 102282

2022

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Location, Location, Location: Compartmentalization of Early Events in Leukotriene Biosynthesis

The Journal of biological chemistry, 2010-08, Vol.285 (33), p.25109-25114

2010

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The Thr-His Connection on the Distal Heme of Catalase-Related Hemoproteins: A Hallmark of Reaction with Fatty Acid Hydroperoxides

Chembiochem : a European journal of chemical biology, 2016-11, Vol.17 (21), p.2000-2006

2016

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Crystal structure of a lipoxygenase in complex with substrate: the arachidonic acid-binding site of 8R-lipoxygenase

The Journal of biological chemistry, 2014-11, Vol.289 (46), p.31905-31913

2014

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Crystal structure of the histone lysine specific demethylase LSD1 complexed with tetrahydrofolate

Protein science, 2014-07, Vol.23 (7), p.993-998

2014

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Anti-inflammatory celastrol promotes a switch from leukotriene biosynthesis to formation of specialized pro-resolving lipid mediators

Pharmacological research, 2021-05, Vol.167, p.105556-105556, Article 105556

2021

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Allosteric Activation of 15‐Lipoxygenase‐1 by Boswellic Acid Induces the Lipid Mediator Class Switch to Promote Resolution of Inflammation

Advanced science, 2023-02, Vol.10 (6), p.e2205604-n/a

2023

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Expression of an 8R-Lipoxygenase From the Coral Plexaura homomalla

Methods in enzymology, 2018, Vol.605, p.33-49

2018

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A 5‑lipoxygenase-specific sequence motif impedes enzyme activity and confers dependence on a partner protein

Biochimica et biophysica acta. Molecular and cell biology of lipids, 2019-04, Vol.1864 (4), p.543-551

2019

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Structure of a Calcium-dependent 11R-Lipoxygenase Suggests a Mechanism for Ca2+ Regulation

The Journal of biological chemistry, 2012-06, Vol.287 (26), p.22377-22386

2012

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The structural basis for specificity in lipoxygenase catalysis

Untangling the web of 5-lipoxygenase-derived products from a molecular and structural perspective: The battle between pro- and anti-inflammatory lipid mediators

Chloride to the rescue

Structural and mechanistic insights into 5-lipoxygenase inhibition by natural products

The Structure of Human 5-Lipoxygenase

Structural basis of antifreeze activity of a bacterial multi-domain antifreeze protein

Structures of Leukotriene Biosynthetic Enzymes and Development of New Therapeutics

Conversion of human 5‐lipoxygenase to a 15‐lipoxygenase by a point mutation to mimic phosphorylation at Serine‐663

Identification of the Substrate Access Portal of 5‑Lipoxygenase

The Structure of Human 15-Lipoxygenase-2 with a Substrate Mimic

5‐Lipoxygenase‐activating protein rescues activity of 5‐lipoxygenase mutations that delay nuclear membrane association and disrupt product formation

Identification and optimization of soluble epoxide hydrolase inhibitors with dual potency towards fatty acid amide hydrolase

Cannabidiol acts as molecular switch in innate immune cells to promote the biosynthesis of inflammation-resolving lipid mediators

Membrane-dependent Activities of Human 15-LOX-2 and Its Murine Counterpart: IMPLICATIONS FOR MURINE MODELS OF ATHEROSCLEROSIS

Optimized Inhibitors of Soluble Epoxide Hydrolase Improve in Vitro Target Residence Time and in Vivo Efficacy

Helical remodeling augments 5-lipoxygenase activity in the synthesis of proinflammatory mediators

Location, Location, Location: Compartmentalization of Early Events in Leukotriene Biosynthesis

The Thr-His Connection on the Distal Heme of Catalase-Related Hemoproteins: A Hallmark of Reaction with Fatty Acid Hydroperoxides

Crystal structure of a lipoxygenase in complex with substrate: the arachidonic acid-binding site of 8R-lipoxygenase

Crystal structure of the histone lysine specific demethylase LSD1 complexed with tetrahydrofolate

Anti-inflammatory celastrol promotes a switch from leukotriene biosynthesis to formation of specialized pro-resolving lipid mediators

Allosteric Activation of 15‐Lipoxygenase‐1 by Boswellic Acid Induces the Lipid Mediator Class Switch to Promote Resolution of Inflammation

Expression of an 8R-Lipoxygenase From the Coral Plexaura homomalla

A 5‑lipoxygenase-specific sequence motif impedes enzyme activity and confers dependence on a partner protein

Structure of a Calcium-dependent 11R-Lipoxygenase Suggests a Mechanism for Ca2+ Regulation

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