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Characterization of the loss of SUMO pathway function on cancer cells and tumor proliferation

PloS one, 2015-04, Vol.10 (4), p.e0123882-e0123882

2015

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Discovery of Novel, Induced-Pocket Binding Oxazolidinones as Potent, Selective, and Orally Bioavailable Tankyrase Inhibitors

Journal of medicinal chemistry, 2013-06, Vol.56 (11), p.4320-4342

2013

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Structural analysis of the lymphocyte-specific kinase Lck in complex with non-selective and Src family selective kinase inhibitors

Structure (London), 1999-06, Vol.7 (6), p.651-661

1999

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Discovery of Aminoquinazolines as Potent, Orally Bioavailable Inhibitors of Lck: Synthesis, SAR, and in Vivo Anti-Inflammatory Activity

Journal of medicinal chemistry, 2006-09, Vol.49 (19), p.5671-5686

2006

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Discovery of 2,4-bis-arylamino-1,3-pyrimidines as insulin-like growth factor-1 receptor (IGF-1R) inhibitors

Bioorganic & medicinal chemistry letters, 2011-04, Vol.21 (8), p.2394-2399

2011

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Probing the roles of SUMOylation in cancer cell biology by using a selective SAE inhibitor

Nature chemical biology, 2017-11, Vol.13 (11), p.1164-1171

2017

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HLA-DR molecules from an antigen-processing mutant cell line are associated with invariant chain peptides

Nature (London), 1992-12, Vol.360 (6403), p.474-477

1992

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TAK-169, a Novel Recombinant Immunotoxin Specific for CD38, Induces Powerful Preclinical Activity Against Patient-Derived Multiple Myeloma Cells

Blood, 2020-11, Vol.136 (Supplement 1), p.11-12

2020

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N-(3-(Phenylcarbamoyl)arylpyrimidine)-5-carboxamides as potent and selective inhibitors of Lck: Structure, synthesis and SAR

Bioorganic & medicinal chemistry, 2008-02, Vol.18 (3), p.1172-1176

2008

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Abstract 3609: Chimeric cytokine receptors increase memory phenotypes and improve expansion and efficacy of CAR-T cell therapies

Cancer research (Chicago, Ill.), 2024-03, Vol.84 (6_Supplement), p.3609-3609

2024

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Abstract 2384: TAK-169, an exceptionally potent CD38 targeted engineered toxin body, as a novel direct cell kill approach for the treatment of multiple myeloma

Cancer research (Chicago, Ill.), 2019-07, Vol.79 (13_Supplement), p.2384-2384

2019

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Rereading the New Criticism ed. by Miranda B. Hickman, John D. McIntyre (review)

James Joyce quarterly, 2014, Vol.51 (2), p.529-532

Newcomb, John Timberman

2014

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Fictions of Autonomy: Modernism from Wilde to de Man by Andrew Goldstone (review)

The Wallace Stevens journal, 2013-09, Vol.37 (2), p.239-242

Newcomb, John Timberman

2013

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Development of Novel Dual Binders as Potent, Selective, and Orally Bioavailable Tankyrase Inhibitors

Journal of medicinal chemistry, 2013-12, Vol.56 (24), p.10003-10015

2013

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Abstract 1147: Probing the roles of SUMOylation in cancer cell biology using a selective SUMO activating enzyme inhibitor

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.1147-1147

2017

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"The Housetop Sea": Cityscape Verse and the Rise of Modern American Poetry

American literature, 2004-06, Vol.76 (2), p.275-306

Newcomb, John Timberman

2004

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The footprint of the twentieth century: American skyscrapers and modernist poems

Modernism/modernity (Baltimore, Md.), 2003-01, Vol.10 (1), p.97

John Timberman Newcomb

2003

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2-Phenylamino-6-cyano-1H-benzimidazole-based isoform selective casein kinase 1 gamma (CK1γ) inhibitors

Bioorganic & medicinal chemistry letters, 2012-09, Vol.22 (17), p.5392-5395

2012

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NASA's Experience in Improving the Microgravity Flight Development Process Utilizing the Language Processing Method

Quality engineering, 2002-12, Vol.15 (2), p.219-231

2002

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A Poem and the Times: Teaching “Justice Denied in Massachusetts” in Context

Modernism/modernity Print Plus, 2016-03, Vol.1 (1)

Newcomb, John

2016

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2-Phenylamino-6-cyano-1H-benzimidazole-based isoform selective casein kinase 1 gamma (CK1γ) inhibitors

Bioorganic & medicinal chemistry letters, 2012-09, Vol.22 (17)

2012

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Novel 2-Aminopyrimidine Carbamates as Potent and Orally Active Inhibitors of Lck: Synthesis, SAR, and in Vivo Antiinflammatory Activity

Journal of medicinal chemistry, 2006-08, Vol.49 (16), p.4981-4991

2006

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A small-molecule inhibitor of the ubiquitin activating enzyme for cancer treatment

Characterization of the loss of SUMO pathway function on cancer cells and tumor proliferation

Discovery of Novel, Induced-Pocket Binding Oxazolidinones as Potent, Selective, and Orally Bioavailable Tankyrase Inhibitors

Structural analysis of the lymphocyte-specific kinase Lck in complex with non-selective and Src family selective kinase inhibitors

Discovery of Aminoquinazolines as Potent, Orally Bioavailable Inhibitors of Lck: Synthesis, SAR, and in Vivo Anti-Inflammatory Activity

Discovery of 2,4-bis-arylamino-1,3-pyrimidines as insulin-like growth factor-1 receptor (IGF-1R) inhibitors

Probing the roles of SUMOylation in cancer cell biology by using a selective SAE inhibitor

HLA-DR molecules from an antigen-processing mutant cell line are associated with invariant chain peptides

TAK-169, a Novel Recombinant Immunotoxin Specific for CD38, Induces Powerful Preclinical Activity Against Patient-Derived Multiple Myeloma Cells

N-(3-(Phenylcarbamoyl)arylpyrimidine)-5-carboxamides as potent and selective inhibitors of Lck: Structure, synthesis and SAR

Abstract 3609: Chimeric cytokine receptors increase memory phenotypes and improve expansion and efficacy of CAR-T cell therapies

Abstract 2384: TAK-169, an exceptionally potent CD38 targeted engineered toxin body, as a novel direct cell kill approach for the treatment of multiple myeloma

Rereading the New Criticism ed. by Miranda B. Hickman, John D. McIntyre (review)

Fictions of Autonomy: Modernism from Wilde to de Man by Andrew Goldstone (review)

Development of Novel Dual Binders as Potent, Selective, and Orally Bioavailable Tankyrase Inhibitors

Abstract 1147: Probing the roles of SUMOylation in cancer cell biology using a selective SUMO activating enzyme inhibitor

"The Housetop Sea": Cityscape Verse and the Rise of Modern American Poetry

The footprint of the twentieth century: American skyscrapers and modernist poems

2-Phenylamino-6-cyano-1H-benzimidazole-based isoform selective casein kinase 1 gamma (CK1γ) inhibitors

Structure-Based Design of Novel 2-Amino-6-phenyl-pyrimido[5′,4′:5,6]pyrimido[1,2-a]benzimidazol-5(6H)-ones as Potent and Orally Active Inhibitors of Lymphocyte Specific Kinase (Lck): Synthesis, SAR, and In Vivo Anti-Inflammatory Activity

NASA's Experience in Improving the Microgravity Flight Development Process Utilizing the Language Processing Method

A Poem and the Times: Teaching “Justice Denied in Massachusetts” in Context

2-Phenylamino-6-cyano-1H-benzimidazole-based isoform selective casein kinase 1 gamma (CK1γ) inhibitors

Novel 2-Aminopyrimidine Carbamates as Potent and Orally Active Inhibitors of Lck: Synthesis, SAR, and in Vivo Antiinflammatory Activity

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