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Efficient C•G-to-G•C base editors developed using CRISPRi screens, target-library analysis, and machine learning

Nature biotechnology, 2021-11, Vol.39 (11), p.1414-1425

2021

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In vivo base editing restores sensory transduction and transiently improves auditory function in a mouse model of recessive deafness

Science translational medicine, 2020-06, Vol.12 (546)

2020

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Pioneer cells established by the [SWI+] prion can promote dispersal and out-crossing in yeast

PLoS biology, 2017-11, Vol.15 (11), p.e2003476-e2003476

2017

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Cross-Kingdom Chemical Communication Drives a Heritable, Mutually Beneficial Prion-Based Transformation of Metabolism

Cell, 2014-08, Vol.158 (5), p.1083-1093

2014

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Functional correction of CFTR mutations in human airway epithelial cells using adenine base editors

Nucleic acids research, 2021-10, Vol.49 (18), p.10558-10572

2021

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Base Editor Correction of COL7A1 in Recessive Dystrophic Epidermolysis Bullosa Patient-Derived Fibroblasts and iPSCs

Journal of investigative dermatology, 2020-02, Vol.140 (2), p.338-347.e5

2020

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Prime editing in mice reveals the essentiality of a single base in driving tissue-specific gene expression

Genome Biology, 2021-03, Vol.22 (1), p.83-83, Article 83

2021

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Chemical modifications of adenine base editor mRNA and guide RNA expand its application scope

Nature communications, 2020-04, Vol.11 (1), p.1979-1979, Article 1979

2020

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In vivo base editing rescues cone photoreceptors in a mouse model of early-onset inherited retinal degeneration

Nature communications, 2022-04, Vol.13 (1), p.1830-1830, Article 1830

2022

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Self-delivering, chemically modified CRISPR RNAs for AAV co-delivery and genome editing in vivo

Nucleic acids research, 2024-01, Vol.52 (2), p.977-997

2024

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A Genetic Tool to Track Protein Aggregates and Control Prion Inheritance

Cell, 2017-11, Vol.171 (4), p.966-979.e18

2017

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Nonviral base editing of KCNJ13 mutation preserves vision in a model of inherited retinal channelopathy

The Journal of clinical investigation, 2023-10, Vol.133 (19), p.1-15

2023

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Shuttle peptide delivers base editor RNPs to rhesus monkey airway epithelial cells in vivo

Nature communications, 2023-12, Vol.14 (1), p.8051-8051, Article 8051

2023

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In vivo somatic cell base editing and prime editing

Molecular therapy, 2021-11, Vol.29 (11), p.3107-3124

2021

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Evaluation and minimization of Cas9-independent off-target DNA editing by cytosine base editors

Nature biotechnology, 2020-05, Vol.38 (5), p.620-628

2020

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Precision genome editing using cytosine and adenine base editors in mammalian cells

Nature protocols, 2021-02, Vol.16 (2), p.1089-1128

2021

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Blessings in disguise: biological benefits of prion-like mechanisms

Trends in cell biology, 2013-06, Vol.23 (6), p.251-259

2013

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Search-and-replace genome editing without double-strand breaks or donor DNA

Nature (London), 2019-12, Vol.576 (7785), p.149-157

2019

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Improving cytidine and adenine base editors by expression optimization and ancestral reconstruction

Nature biotechnology, 2018-10, Vol.36 (9), p.843-846

2018

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Protospacer modification improves base editing of a canonical splice site variant and recovery of CFTR function in human airway epithelial cells

Molecular therapy. Nucleic acids, 2023-09, Vol.33, p.335-350

2023

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Precise correction of a spectrum of β-thalassemia mutations in coding and non-coding regions by base editors

Molecular therapy. Nucleic acids, 2024-06, Vol.35 (2), p.102205, Article 102205

2024

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Enhanced prime editing systems by manipulating cellular determinants of editing outcomes

Cell, 2021-10, Vol.184 (22), p.5635-5652.e29

2021

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Engineered pegRNAs improve prime editing efficiency

Nature biotechnology, 2022-03, Vol.40 (3), p.402-410

2022

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In vivo base editing by a single i.v. vector injection for treatment of hemoglobinopathies

JCI insight, 2022-10, Vol.7 (19)

2022

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Efficient C•G-to-G•C base editors developed using CRISPRi screens, target-library analysis, and machine learning

In vivo base editing restores sensory transduction and transiently improves auditory function in a mouse model of recessive deafness

Pioneer cells established by the [SWI+] prion can promote dispersal and out-crossing in yeast

Cross-Kingdom Chemical Communication Drives a Heritable, Mutually Beneficial Prion-Based Transformation of Metabolism

Functional correction of CFTR mutations in human airway epithelial cells using adenine base editors

Base Editor Correction of COL7A1 in Recessive Dystrophic Epidermolysis Bullosa Patient-Derived Fibroblasts and iPSCs

Prime editing in mice reveals the essentiality of a single base in driving tissue-specific gene expression

Chemical modifications of adenine base editor mRNA and guide RNA expand its application scope

In vivo base editing rescues cone photoreceptors in a mouse model of early-onset inherited retinal degeneration

Self-delivering, chemically modified CRISPR RNAs for AAV co-delivery and genome editing in vivo

A Genetic Tool to Track Protein Aggregates and Control Prion Inheritance

Nonviral base editing of KCNJ13 mutation preserves vision in a model of inherited retinal channelopathy

Shuttle peptide delivers base editor RNPs to rhesus monkey airway epithelial cells in vivo

Amphiphilic shuttle peptide delivers base editor ribonucleoprotein to correct the CFTR R553X mutation in well-differentiated airway epithelial cells

In vivo somatic cell base editing and prime editing

Evaluation and minimization of Cas9-independent off-target DNA editing by cytosine base editors

Precision genome editing using cytosine and adenine base editors in mammalian cells

Blessings in disguise: biological benefits of prion-like mechanisms

Search-and-replace genome editing without double-strand breaks or donor DNA

Improving cytidine and adenine base editors by expression optimization and ancestral reconstruction

Protospacer modification improves base editing of a canonical splice site variant and recovery of CFTR function in human airway epithelial cells

Precise correction of a spectrum of β-thalassemia mutations in coding and non-coding regions by base editors

Enhanced prime editing systems by manipulating cellular determinants of editing outcomes

Engineered pegRNAs improve prime editing efficiency

In vivo base editing by a single i.v. vector injection for treatment of hemoglobinopathies

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