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Total Synthesis of Thiostrepton. Retrosynthetic Analysis and Construction of Key Building Blocks

Journal of the American Chemical Society, 2005-08, Vol.127 (31), p.11159-11175

2005

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Total Synthesis of Thiostrepton. Assembly of Key Building Blocks and Completion of the Synthesis

Journal of the American Chemical Society, 2005-08, Vol.127 (31), p.11176-11183

2005

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Corrigendum to “Optimization of a novel piperazinone series as potent selective peripheral covalent BTK inhibitors” [Bioorg. Med. Chem. Lett. 60 (2022) 128549]

Bioorganic & medicinal chemistry letters, 2022-09, Vol.72, p.128856-128856, Article 128856

2022

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An expedient synthesis of spiroketals: model studies for the calyculin C16–C25 fragment

Tetrahedron, 2004-10, Vol.60 (41), p.9199-9204

2004

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Discovery of Potent and Brain-Penetrant Tau Tubulin Kinase 1 (TTBK1) Inhibitors that Lower Tau Phosphorylation In Vivo

Journal of medicinal chemistry, 2021-05, Vol.64 (9), p.6358-6380

2021

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Discovery and Preclinical Characterization of BIIB129, a Covalent, Selective, and Brain-Penetrant BTK Inhibitor for the Treatment of Multiple Sclerosis

Journal of medicinal chemistry, 2024-05, Vol.67 (10), p.8122-8140

2024

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A new organocatalyst for 1,3-dipolar cycloadditions of nitrones to α,β-unsaturated aldehydes

Tetrahedron letters, 2007-01, Vol.48 (2), p.277-280

2007

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Semisynthetic Cyclopamine Analogues as Potent and Orally Bioavailable Hedgehog Pathway Antagonists

Journal of medicinal chemistry, 2008-11, Vol.51 (21), p.6646-6649

2008

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(+)-Camphor-derived amino alcohols as ligands for the catalytic enantioselective addition of diethylzinc to benzaldehydes

Tetrahedron: asymmetry, 2001-07, Vol.12 (12), p.1771-1777

2001

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Abstract 5564: Total synthesis of 6-deoxypladienolide D and assessment of splicing inhibitory activity in a mutant SF3B1 cancer cell line

Cancer research (Chicago, Ill.), 2015-08, Vol.75 (15_Supplement), p.5564-5564

2015

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Abstract 1891: Pharmacological target validation studies of fatty acid synthase in carcinoma using the potent, selective and orally bioavailable inhibitor IPI-9119

Cancer research (Chicago, Ill.), 2013-04, Vol.73 (8_Supplement), p.1891-1891

2013

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A Biomimetically Inspired Synthesis of the Dehydropiperidine Domain of Thiostrepton

Angewandte Chemie International Edition, 2002-06, Vol.41 (11), p.1941-1945

2002

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Synthetic Studies on Thiostrepton: Construction of Thiostrepton Analogues with the Thiazoline-Containing Macrocycle

Angewandte Chemie International Edition, 2003-07, Vol.42 (29), p.3418-3424

2003

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An expedient synthesis of spiroketals: model studies for the calyculin C 16–C 25 fragment

Tetrahedron, 2004-10, Vol.60 (41), p.9199-9204

2004

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Synthesis of a 10-Membered Carbocycle By Olefin Metathesis

Angewandte Chemie International Edition, 2001-11, Vol.40 (21), p.4060-4062

2001

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Total Synthesis of nor-1,6-Germacradien-5-ols

Journal of organic chemistry, 2002-03, Vol.67 (5), p.1554-1560

2002

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Synthesis of a 10-Membered Carbocycle By Olefin Metathesis

Angewandte Chemie International Edition, 2002-01, Vol.41 (1), p.16-16

2002

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Synthesis of a 10-Membered Carbocycle By Olefin Metathesis

Angewandte Chemie, 2002-01, Vol.114 (1), p.16-16

2002

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Synthesis of a 10-Membered Carbocycle By Olefin Metathesis

Angewandte Chemie, 2001-11, Vol.113 (21), p.4184-4186

2001

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Synthesis of Fmoc-Protected trans-4-Methylproline

Journal of organic chemistry, 2001-03, Vol.66 (6), p.2061-2066

2001

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Synthesis of a 10-Membered Carbocycle By Olefin Metathesis Financial support has been provided by the Academy of Finland and HUT

Angewandte Chemie International Edition, 2001-11, Vol.40 (21), p.4060-4062

2001

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A Biomimetically Inspired Synthesis of the Dehydropiperidine Domain of Thiostrepton We thank Drs. D. H. Huang and L. Pasternack, G. Suizdak, and R. Chadja for NMR spectroscopic, mass spectrometric, and X-ray crystallographic assistance, respectively. Financial support for this work was provided by The Skaggs Institute for Chemical Biology, the National Institutes of Health (USA), fellowships from The Academy of Finland (M.N.), The Skaggs Institute for Research (M.Z.), and Bayer AG (S.B.), and gr

Angewandte Chemie International Edition, 2002-06, Vol.41 (11), p.1941

2002

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The Hydrogenation of (4R)-4-[(tert-Butoxycarbonyl)amino]-2-methyl-2-penten-5-olide: A Precursor of trans-4-Methylproline

Synlett, 2001, Vol.2001 (5), p.0640-0642

2001

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Synthesis of a 10-Membered Carbocycle By Olefin Metathesis

Angewandte Chemie, 2002-01, Vol.114 (1), p.16-16

2002

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Total Synthesis of Thiostrepton. Retrosynthetic Analysis and Construction of Key Building Blocks

Total Synthesis of Thiostrepton. Assembly of Key Building Blocks and Completion of the Synthesis

Corrigendum to “Optimization of a novel piperazinone series as potent selective peripheral covalent BTK inhibitors” [Bioorg. Med. Chem. Lett. 60 (2022) 128549]

An expedient synthesis of spiroketals: model studies for the calyculin C16–C25 fragment

Discovery of Potent and Brain-Penetrant Tau Tubulin Kinase 1 (TTBK1) Inhibitors that Lower Tau Phosphorylation In Vivo

Discovery and Preclinical Characterization of BIIB129, a Covalent, Selective, and Brain-Penetrant BTK Inhibitor for the Treatment of Multiple Sclerosis

A new organocatalyst for 1,3-dipolar cycloadditions of nitrones to α,β-unsaturated aldehydes

Semisynthetic Cyclopamine Analogues as Potent and Orally Bioavailable Hedgehog Pathway Antagonists

Total Synthesis of 6‑Deoxypladienolide D and Assessment of Splicing Inhibitory Activity in a Mutant SF3B1 Cancer Cell Line

(+)-Camphor-derived amino alcohols as ligands for the catalytic enantioselective addition of diethylzinc to benzaldehydes

Abstract 5564: Total synthesis of 6-deoxypladienolide D and assessment of splicing inhibitory activity in a mutant SF3B1 cancer cell line

Abstract 1891: Pharmacological target validation studies of fatty acid synthase in carcinoma using the potent, selective and orally bioavailable inhibitor IPI-9119

A Biomimetically Inspired Synthesis of the Dehydropiperidine Domain of Thiostrepton

Synthetic Studies on Thiostrepton: Construction of Thiostrepton Analogues with the Thiazoline-Containing Macrocycle

An expedient synthesis of spiroketals: model studies for the calyculin C 16–C 25 fragment

Synthesis of a 10-Membered Carbocycle By Olefin Metathesis

Total Synthesis of nor-1,6-Germacradien-5-ols

Synthesis of a 10-Membered Carbocycle By Olefin Metathesis

Synthesis of a 10-Membered Carbocycle By Olefin Metathesis

Synthesis of a 10-Membered Carbocycle By Olefin Metathesis

Synthesis of Fmoc-Protected trans-4-Methylproline

Synthesis of a 10-Membered Carbocycle By Olefin Metathesis Financial support has been provided by the Academy of Finland and HUT

The Hydrogenation of (4R)-4-[(tert-Butoxycarbonyl)amino]-2-methyl-2-penten-5-olide: A Precursor of trans-4-Methylproline

Synthesis of a 10-Membered Carbocycle By Olefin Metathesis

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