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Phase 1 First-in-Human Trial of the Vascular Disrupting Agent Plinabulin (NPI-2358) in Patients with Solid Tumors or Lymphomas

Clinical cancer research, 2010-12, Vol.16 (23), p.5892-5899

2010

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Structure−Activity Relationship Studies of Salinosporamide A (NPI-0052), a Novel Marine Derived Proteasome Inhibitor

Journal of medicinal chemistry, 2005-06, Vol.48 (11), p.3684-3687

2005

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Leaving Groups Prolong the Duration of 20S Proteasome Inhibition and Enhance the Potency of Salinosporamides

Journal of medicinal chemistry, 2008-11, Vol.51 (21), p.6711-6724

2008

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Phase 1 clinical trial of the novel proteasome inhibitor marizomib with the histone deacetylase inhibitor vorinostat in patients with melanoma, pancreatic and lung cancer based on in vitro assessments of the combination

Investigational new drugs, 2012-12, Vol.30 (6), p.2303-2317

2012

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Lajollamycin, a nitro-tetraene spiro-β-lactone-γ-lactam antibiotic from the marine actinomycete Streptomyces nodosus

Journal of natural products (Washington, D.C.), 2005-02, Vol.68 (2), p.240-243

2005

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Salinosporamides D−J from the Marine Actinomycete Salinispora tropica, Bromosalinosporamide, and Thioester Derivatives Are Potent Inhibitors of the 20S Proteasome

Journal of natural products (Washington, D.C.), 2007-02, Vol.70 (2), p.269-276

2007

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Antiprotealide Is a Natural Product

Journal of natural products (Washington, D.C.), 2009-02, Vol.72 (2), p.295-297

2009

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Salinosporamide A (NPI-0052) potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through down-modulation of NF-κB–regulated gene products

Blood, 2007-10, Vol.110 (7), p.2286-2295

2007

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Proteasome regulator marizomib (NPI-0052) exhibits prolonged inhibition, attenuated efflux, and greater cytotoxicity than its reversible analogs

The Journal of pharmacology and experimental therapeutics, 2011-05, Vol.337 (2), p.479

2011

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NB1011 induces Ser15 phosphorylation of p53 and activates the G2/M checkpoint

Anti-cancer drugs, 2003-07, Vol.14 (6), p.449-455

2003

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Oncogenic Homeodomain Transcription Factor E2A-Pbx1 Activates a Novel WNT Gene in Pre-B Acute Lymphoblastoid Leukemia

Proceedings of the National Academy of Sciences - PNAS, 1999-09, Vol.96 (20), p.11464-11469

1999

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NPI-0052 Enhances Tumoricidal Response to Conventional Cancer Therapy in a Colon Cancer Model

Clinical cancer research, 2006-11, Vol.12 (22), p.6758-6764

2006

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Nucleoside transport inhibitors, dipyridamole and p-nitrobenzylthioinosine, selectively potentiate the antitumor activity of NB1011

Anti-cancer drugs, 2002-01, Vol.13 (1), p.29-36

2002

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A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib

Cancer cell, 2005-11, Vol.8 (5), p.407-419

2005

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The Hexapeptide LFPWMR in Hoxb-8 is Required for Cooperative DNA Binding with Pbx1 and Pbx2 Proteins

Proceedings of the National Academy of Sciences - PNAS, 1995-09, Vol.92 (20), p.9166-9170

1995

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NPI-2358 is a tubulin-depolymerizing agent: in-vitro evidence for activity as a tumor vascular-disrupting agent

Anti-cancer drugs, 2006-01, Vol.17 (1), p.25-31

2006

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Inhibition of Cell Growth by NB1011 Requires High Thymidylate Synthase Levels and Correlates with p53, p21, Bax, and GADD45 Induction

Molecular cancer therapeutics, 2002-04, Vol.1 (6), p.377

2002

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Lajollamycin, a Nitro-tetraene Spiro-β-lactone-γ-lactam Antibiotic from the Marine Actinomycete Streptomyces n odosus

Journal of natural products (Washington, D.C.), 2005-02, Vol.68 (2), p.240-243

2005

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Pbx raises the DNA binding specificity but not the selectivity of antennapedia Hox proteins

Molecular and Cellular Biology, 1997-08, Vol.17 (8), p.4696-4706

1997

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Salinosporamide A (NPI-0052) potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through down-modulation of NF-kappaB regulated gene products

Blood, 2007-10, Vol.110 (7), p.2286

2007

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Adenovirus-mediated gene transfer of MMAC1/PTEN to glioblastoma cells inhibits S phase entry by the recruitment of p27Kip1 into cyclin E/CDK2 complexes

Cancer research (Chicago, Ill.), 1999-05, Vol.59 (10), p.2318-2323

1999

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In planta analysis of the Agrobacterium tumefaciens T-cyt gene promoter: identification of an upstream region essential for promoter activity in leaf, stem and root cells of transgenic tobacco

Plant molecular biology, 1993-08, Vol.22 (5), p.923-929

1993

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Molecular characterization of the virulence gene virA of the Agrobacterium tumefaciens octopine Ti plasmid

Plant molecular biology, 1987-11, Vol.9 (6), p.635-645

1987

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From Natural Product to Clinical Trials: NPI-0052 (Salinosporamide A), a Marine Actinomycete-Derived Anticancer Agent

Natural Product Chemistry for Drug Discovery, 2010, p.1-1

2010

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Molecular characterization of the virulence gene virA of the Agrobacterium tumefaciens octopine Ti plasmid

Plant molecular biology, 1988-03, Vol.11 (2), p.227-237

1988

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Phase 1 First-in-Human Trial of the Vascular Disrupting Agent Plinabulin (NPI-2358) in Patients with Solid Tumors or Lymphomas

Structure−Activity Relationship Studies of Salinosporamide A (NPI-0052), a Novel Marine Derived Proteasome Inhibitor

Leaving Groups Prolong the Duration of 20S Proteasome Inhibition and Enhance the Potency of Salinosporamides

Phase 1 clinical trial of the novel proteasome inhibitor marizomib with the histone deacetylase inhibitor vorinostat in patients with melanoma, pancreatic and lung cancer based on in vitro assessments of the combination

Lajollamycin, a nitro-tetraene spiro-β-lactone-γ-lactam antibiotic from the marine actinomycete Streptomyces nodosus

Salinosporamides D−J from the Marine Actinomycete Salinispora tropica, Bromosalinosporamide, and Thioester Derivatives Are Potent Inhibitors of the 20S Proteasome

Antiprotealide Is a Natural Product

Salinosporamide A (NPI-0052) potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through down-modulation of NF-κB–regulated gene products

Proteasome regulator marizomib (NPI-0052) exhibits prolonged inhibition, attenuated efflux, and greater cytotoxicity than its reversible analogs

NB1011 induces Ser15 phosphorylation of p53 and activates the G2/M checkpoint

Oncogenic Homeodomain Transcription Factor E2A-Pbx1 Activates a Novel WNT Gene in Pre-B Acute Lymphoblastoid Leukemia

NPI-0052 Enhances Tumoricidal Response to Conventional Cancer Therapy in a Colon Cancer Model

Nucleoside transport inhibitors, dipyridamole and p-nitrobenzylthioinosine, selectively potentiate the antitumor activity of NB1011

A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib

The Hexapeptide LFPWMR in Hoxb-8 is Required for Cooperative DNA Binding with Pbx1 and Pbx2 Proteins

NPI-2358 is a tubulin-depolymerizing agent: in-vitro evidence for activity as a tumor vascular-disrupting agent

Inhibition of Cell Growth by NB1011 Requires High Thymidylate Synthase Levels and Correlates with p53, p21, Bax, and GADD45 Induction

Lajollamycin, a Nitro-tetraene Spiro-β-lactone-γ-lactam Antibiotic from the Marine Actinomycete Streptomyces n odosus

Pbx raises the DNA binding specificity but not the selectivity of antennapedia Hox proteins

Salinosporamide A (NPI-0052) potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through down-modulation of NF-kappaB regulated gene products

Adenovirus-mediated gene transfer of MMAC1/PTEN to glioblastoma cells inhibits S phase entry by the recruitment of p27Kip1 into cyclin E/CDK2 complexes

In planta analysis of the Agrobacterium tumefaciens T-cyt gene promoter: identification of an upstream region essential for promoter activity in leaf, stem and root cells of transgenic tobacco

Molecular characterization of the virulence gene virA of the Agrobacterium tumefaciens octopine Ti plasmid

From Natural Product to Clinical Trials: NPI-0052 (Salinosporamide A), a Marine Actinomycete-Derived Anticancer Agent

Molecular characterization of the virulence gene virA of the Agrobacterium tumefaciens octopine Ti plasmid

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