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Molecular mechanisms of antibody somatic hypermutation

Annual review of biochemistry, 2007-01, Vol.76 (1), p.1-22

2007

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Germline ablation of SMUG1 DNA glycosylase causes loss of 5-hydroxymethyluracil- and UNG-backup uracil-excision activities and increases cancer predisposition of Ung-/-Msh2-/- mice

Nucleic acids research, 2012-07, Vol.40 (13), p.6016

2012

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DNA deaminases induce break-associated mutation showers with implication of APOBEC3B and 3A in breast cancer kataegis

eLife, 2013-04, Vol.2, p.e00534-e00534

2013

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Antibody diversification by somatic mutation: from Burnet onwards

Immunology and cell biology, 2008-02, Vol.86 (2), p.124-132

Neuberger, Michael S

2008

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Altering the spectrum of immunoglobulin V gene somatic hypermutation by modifying the active site of AID

The Journal of experimental medicine, 2010-01, Vol.207 (1), p.141-153

2010

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The in vivo pattern of AID targeting to immunoglobulin switch regions deduced from mutation spectra in msh2-/- ung-/- mice

The Journal of experimental medicine, 2006-09, Vol.203 (9), p.2085-2094

2006

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Cytoplasmic activation-induced cytidine deaminase (AID) exists in stoichiometric complex with translation elongation factor 1α (eEF1A)

Proceedings of the National Academy of Sciences - PNAS, 2011-11, Vol.108 (45), p.18366-18371

2011

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Evolution of the AID/APOBEC family of polynucleotide (deoxy)cytidine deaminases

Molecular biology and evolution, 2005-02, Vol.22 (2), p.367-377

2005

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stability of AID and its function in class-switching are critically sensitive to the identity of its nuclear-export sequence

Proceedings of the National Academy of Sciences - PNAS, 2009-04, Vol.106 (16), p.6736-6741

2009

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DNA Deamination Mediates Innate Immunity to Retroviral Infection

Cell, 2003-06, Vol.113 (6), p.803-809

2003

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Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase

Nature (London), 2002-09, Vol.419 (6902), p.43-48

2002

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Deficiency in APOBEC2 Leads to a Shift in Muscle Fiber Type, Diminished Body Mass, and Myopathy

The Journal of biological chemistry, 2010-03, Vol.285 (10), p.7111-7118

2010

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The Vif Protein of HIV Triggers Degradation of the Human Antiretroviral DNA Deaminase APOBEC3G

Current biology, 2003-11, Vol.13 (22), p.2009-2013

2003

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Interaction between Antibody-Diversification Enzyme AID and Spliceosome-Associated Factor CTNNBL1

Molecular cell, 2008-08, Vol.31 (4), p.474-484

2008

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AID upmutants isolated using a high-throughput screen highlight the immunity/cancer balance limiting DNA deaminase activity

Nature structural & molecular biology, 2009-07, Vol.16 (7), p.769-776

2009

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Mouse APOBEC3 Restricts Friend Leukemia Virus Infection and Pathogenesis In Vivo

Journal of Virology, 2008-11, Vol.82 (22), p.10998-11008

2008

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The AKV Murine Leukemia Virus Is Restricted and Hypermutated by Mouse APOBEC3

Journal of Virology, 2009-11, Vol.83 (22), p.11550-11559

2009

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The relationship between hypothesis and experiment in unveiling the mechanisms of antibody gene diversification

The FASEB journal, 2011-04, Vol.25 (4), p.1123-1132

2011

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DNA Deamination in Immunity: AID in the Context of Its APOBEC Relatives

AID for Immunoglobulin Diversity, 2007, Vol.94, p.37-73

2007

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Affinity Dependence of the B Cell Response to Antigen: A Threshold, a Ceiling, and the Importance of Off-Rate

Immunity (Cambridge, Mass.), 1998-06, Vol.8 (6), p.751-759

1998

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Human APOBEC3G Can Restrict Retroviral Infection in Avian Cells and Acts Independently of both UNG and SMUG1

Journal of Virology, 2008-05, Vol.82 (9), p.4660-4664

2008

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In Vitro Deamination of Cytosine to Uracil in Single-stranded DNA by Apolipoprotein B Editing Complex Catalytic Subunit 1 (APOBEC1)

The Journal of biological chemistry, 2003-05, Vol.278 (22), p.19583-19586

2003

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Mice Deficient in APOBEC2 and APOBEC3

Molecular and Cellular Biology, 2005-08, Vol.25 (16), p.7270-7277

2005

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TdT-Accessible Breaks Are Scattered over the Immunoglobulin V Domain in a Constitutively Hypermutating B Cell Line

Immunity (Cambridge, Mass.), 1998-12, Vol.9 (6), p.859-869

1998

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B cells extract and present immobilized antigen: implications for affinity discrimination

The EMBO journal, 2000-02, Vol.19 (4), p.513-520

2000

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Molecular mechanisms of antibody somatic hypermutation

Germline ablation of SMUG1 DNA glycosylase causes loss of 5-hydroxymethyluracil- and UNG-backup uracil-excision activities and increases cancer predisposition of Ung-/-Msh2-/- mice

DNA deaminases induce break-associated mutation showers with implication of APOBEC3B and 3A in breast cancer kataegis

Antibody diversification by somatic mutation: from Burnet onwards

Altering the spectrum of immunoglobulin V gene somatic hypermutation by modifying the active site of AID

The in vivo pattern of AID targeting to immunoglobulin switch regions deduced from mutation spectra in msh2-/- ung-/- mice

Cytoplasmic activation-induced cytidine deaminase (AID) exists in stoichiometric complex with translation elongation factor 1α (eEF1A)

Evolution of the AID/APOBEC family of polynucleotide (deoxy)cytidine deaminases

stability of AID and its function in class-switching are critically sensitive to the identity of its nuclear-export sequence

DNA Deamination Mediates Innate Immunity to Retroviral Infection

Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase

Deficiency in APOBEC2 Leads to a Shift in Muscle Fiber Type, Diminished Body Mass, and Myopathy

The Vif Protein of HIV Triggers Degradation of the Human Antiretroviral DNA Deaminase APOBEC3G

Interaction between Antibody-Diversification Enzyme AID and Spliceosome-Associated Factor CTNNBL1

AID upmutants isolated using a high-throughput screen highlight the immunity/cancer balance limiting DNA deaminase activity

Mouse APOBEC3 Restricts Friend Leukemia Virus Infection and Pathogenesis In Vivo

The AKV Murine Leukemia Virus Is Restricted and Hypermutated by Mouse APOBEC3

The relationship between hypothesis and experiment in unveiling the mechanisms of antibody gene diversification

DNA Deamination in Immunity: AID in the Context of Its APOBEC Relatives

Affinity Dependence of the B Cell Response to Antigen: A Threshold, a Ceiling, and the Importance of Off-Rate

Human APOBEC3G Can Restrict Retroviral Infection in Avian Cells and Acts Independently of both UNG and SMUG1

In Vitro Deamination of Cytosine to Uracil in Single-stranded DNA by Apolipoprotein B Editing Complex Catalytic Subunit 1 (APOBEC1)

Mice Deficient in APOBEC2 and APOBEC3

TdT-Accessible Breaks Are Scattered over the Immunoglobulin V Domain in a Constitutively Hypermutating B Cell Line

B cells extract and present immobilized antigen: implications for affinity discrimination

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