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Biosynthesis of Cholesterol and Other Sterols

Chemical reviews, 2011-10, Vol.111 (10), p.6423-6451

Nes, W. David

2011

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Unearthing the Janus-face cholesterogenesis pathways in cancer

Biochemical pharmacology, 2022-02, Vol.196, p.114611-114611, Article 114611

2022

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Both methylerythritol phosphate and mevalonate pathways contribute to biosynthesis of each of the major isoprenoid classes in young cotton seedlings

Phytochemistry (Oxford), 2014-02, Vol.98, p.110-119

2014

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Identification of Natural RORγ Ligands that Regulate the Development of Lymphoid Cells

Cell metabolism, 2015-02, Vol.21 (2), p.286-298

2015

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Enzymatic chokepoints and synergistic drug targets in the sterol biosynthesis pathway of Naegleria fowleri

PLoS pathogens, 2018-09, Vol.14 (9), p.e1007245

2018

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A nematode sterol C4α-methyltransferase catalyzes a new methylation reaction responsible for sterol diversity[S]

Journal of lipid research, 2020-02, Vol.61 (2), p.192-204

2020

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Sterol methyltransferase a target for anti-amoeba therapy: towards transition state analog and suicide substrate drug design

Journal of lipid research, 2017-12, Vol.58 (12), p.2310-2323

2017

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Steroidal Antimetabolites Protect Mice against Trypanosoma brucei

Molecules (Basel, Switzerland), 2022-06, Vol.27 (13), p.4088

2022

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CYP51 is an essential drug target for the treatment of primary amoebic meningoencephalitis (PAM)

PLoS neglected tropical diseases, 2017-12, Vol.11 (12), p.e0006104

2017

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Druggable Sterol Metabolizing Enzymes in Infectious Diseases: Cell Targets to Therapeutic Leads

Biomolecules (Basel, Switzerland), 2024-02, Vol.14 (3), p.249

2024

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Binding of a physiological substrate causes large-scale conformational reorganization in cytochrome P450 51

The Journal of biological chemistry, 2018-12, Vol.293 (50), p.19344-19353

2018

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Steroidal antibiotics are antimetabolites of Acanthamoeba steroidogenesis with phylogenetic implications

Journal of lipid research, 2019-05, Vol.60 (5), p.981-994

2019

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Structural complex of sterol 14α-demethylase (CYP51) with 14α-methylenecyclopropyl-Δ7-24, 25-dihydrolanosterol

Journal of lipid research, 2012-02, Vol.53 (2), p.311-320

2012

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24-Methylenecyclopropane steroidal inhibitors: A Trojan horse in ergosterol biosynthesis that prevents growth of Trypanosoma brucei

Biochimica et biophysica acta. Molecular and cell biology of lipids, 2017-03, Vol.1862 (3), p.305-313

2017

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Mechanism of Binding of Prothioconazole to Mycosphaerella graminicola CYP51 Differs from That of Other Azole Antifungals

Applied and Environmental Microbiology, 2011-02, Vol.77 (4), p.1460-1465

2011

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Discovery of an ergosterol-signaling factor that regulates Trypanosoma brucei growth[S]

Journal of lipid research, 2015-02, Vol.56 (2), p.331-341

2015

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Azole Binding Properties of Candida albicans Sterol 14-α Demethylase (CaCYP51)

Antimicrobial Agents and Chemotherapy, 2010-10, Vol.54 (10), p.4235-4245

2010

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Expression, Purification, and Characterization of Aspergillus fumigatus Sterol 14-α Demethylase (CYP51) Isoenzymes A and B

Antimicrobial Agents and Chemotherapy, 2010-10, Vol.54 (10), p.4225-4234

2010

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Novel sterol metabolic network of Trypanosoma brucei procyclic and bloodstream forms

Biochemical journal, 2012-04, Vol.443 (1), p.267-277

2012

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Characterization, mutagenesis and mechanistic analysis of an ancient algal sterol C24-methyltransferase: Implications for understanding sterol evolution in the green lineage

Phytochemistry (Oxford), 2015-05, Vol.113, p.64-72

2015

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CYP51: A Major Drug Target in the Cytochrome P450 Superfamily

Lipids, 2008-12, Vol.43 (12), p.1117-1125

2008

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Cryptococcus neoformans Site-2 protease is required for virulence and survival in the presence of azole drugs

Molecular microbiology, 2009-11, Vol.74 (3), p.672-690

2009

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Sterol Biosynthesis Inhibitors: Potential for Transition State Analogs and Mechanism-Based Inactivators Targeted at Sterol Methyltransferase

Lipids, 2007-02, Vol.42 (1), p.15-33

2007

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Cloning, functional expression and phylogenetic analysis of plant sterol 24C-methyltransferases involved in sitosterol biosynthesis

Phytochemistry (Oxford), 2009-12, Vol.70 (17), p.1982-1998

2009

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C-24-methylation of 26-fluorocycloartenols by recombinant sterol C-24-methyltransferase from soybean: evidence for channel switching and its phylogenetic implications

Biochemical journal, 2013-12, Vol.456 (2), p.253-262

2013

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Biosynthesis of Cholesterol and Other Sterols

Unearthing the Janus-face cholesterogenesis pathways in cancer

Both methylerythritol phosphate and mevalonate pathways contribute to biosynthesis of each of the major isoprenoid classes in young cotton seedlings

Identification of Natural RORγ Ligands that Regulate the Development of Lymphoid Cells

Enzymatic chokepoints and synergistic drug targets in the sterol biosynthesis pathway of Naegleria fowleri

A nematode sterol C4α-methyltransferase catalyzes a new methylation reaction responsible for sterol diversity[S]

Sterol methyltransferase a target for anti-amoeba therapy: towards transition state analog and suicide substrate drug design

Steroidal Antimetabolites Protect Mice against Trypanosoma brucei

CYP51 is an essential drug target for the treatment of primary amoebic meningoencephalitis (PAM)

Druggable Sterol Metabolizing Enzymes in Infectious Diseases: Cell Targets to Therapeutic Leads

Binding of a physiological substrate causes large-scale conformational reorganization in cytochrome P450 51

Steroidal antibiotics are antimetabolites of Acanthamoeba steroidogenesis with phylogenetic implications

Structural complex of sterol 14α-demethylase (CYP51) with 14α-methylenecyclopropyl-Δ7-24, 25-dihydrolanosterol

24-Methylenecyclopropane steroidal inhibitors: A Trojan horse in ergosterol biosynthesis that prevents growth of Trypanosoma brucei

Mechanism of Binding of Prothioconazole to Mycosphaerella graminicola CYP51 Differs from That of Other Azole Antifungals

Discovery of an ergosterol-signaling factor that regulates Trypanosoma brucei growth[S]

Azole Binding Properties of Candida albicans Sterol 14-α Demethylase (CaCYP51)

Expression, Purification, and Characterization of Aspergillus fumigatus Sterol 14-α Demethylase (CYP51) Isoenzymes A and B

Novel sterol metabolic network of Trypanosoma brucei procyclic and bloodstream forms

Characterization, mutagenesis and mechanistic analysis of an ancient algal sterol C24-methyltransferase: Implications for understanding sterol evolution in the green lineage

CYP51: A Major Drug Target in the Cytochrome P450 Superfamily

Cryptococcus neoformans Site-2 protease is required for virulence and survival in the presence of azole drugs

Sterol Biosynthesis Inhibitors: Potential for Transition State Analogs and Mechanism-Based Inactivators Targeted at Sterol Methyltransferase

Cloning, functional expression and phylogenetic analysis of plant sterol 24C-methyltransferases involved in sitosterol biosynthesis

C-24-methylation of 26-fluorocycloartenols by recombinant sterol C-24-methyltransferase from soybean: evidence for channel switching and its phylogenetic implications

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