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Towards a new combination therapy for tuberculosis with next generation benzothiazinones

EMBO molecular medicine, 2014-03, Vol.6 (3), p.372-383

2014

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DprE1 Is a Vulnerable Tuberculosis Drug Target Due to Its Cell Wall Localization

ACS chemical biology, 2015-07, Vol.10 (7), p.1631-1636

2015

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Towards a new tuberculosis drug: pyridomycin – nature's isoniazid

EMBO molecular medicine, 2012-10, Vol.4 (10), p.1032-1042

2012

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Biochemical and Structural Characterization of Bisubstrate Inhibitors of BasE, the Self-Standing Nonribosomal Peptide Synthetase Adenylate-Forming Enzyme of Acinetobactin Synthesis

Biochemistry (Easton), 2010-11, Vol.49 (43), p.9292-9305

2010

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Fluorescent Benzothiazinone Analogues Efficiently and Selectively Label Dpre1 in Mycobacteria and Actinobacteria

ACS chemical biology, 2018-11, Vol.13 (11), p.3184-3192

2018

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Structural basis for benzothiazinone-mediated killing of Mycobacterium tuberculosis

Science translational medicine, 2012-09, Vol.4 (150), p.150ra121

2012

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Inhibition of Siderophore Biosynthesis in Mycobacterium tuberculosis with Nucleoside Bisubstrate Analogues: Structure−Activity Relationships of the Nucleobase Domain of 5′-O-[N-(Salicyl)sulfamoyl]adenosine

Journal of medicinal chemistry, 2008-09, Vol.51 (17), p.5349-5370

2008

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The 8-Pyrrole-Benzothiazinones Are Noncovalent Inhibitors of DprE1 from Mycobacterium tuberculosis

Antimicrobial agents and chemotherapy, 2015-08, Vol.59 (8), p.4446-4452

2015

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Downregulation of Ubiquitin-Specific Protease 15 (USP15) Does Not Provide Therapeutic Benefit in Experimental Mesial Temporal Lobe Epilepsy

Molecular neurobiology, 2024-04, Vol.61 (4), p.2367-2389

2024

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Inhibition of Siderophore Biosynthesis by 2-Triazole Substituted Analogues of 5′-O-[N-(Salicyl)sulfamoyl]adenosine: Antibacterial Nucleosides Effective against Mycobacterium tuberculosis

Journal of medicinal chemistry, 2008-12, Vol.51 (23), p.7495-7507

2008

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Non-Nucleoside Inhibitors of BasE, an Adenylating Enzyme in the Siderophore Biosynthetic Pathway of the Opportunistic Pathogen Acinetobacter baumannii

Journal of medicinal chemistry, 2013-03, Vol.56 (6), p.2385-2405

2013

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Characterization of DprE1-Mediated Benzothiazinone Resistance in Mycobacterium tuberculosis

Antimicrobial agents and chemotherapy, 2016-11, Vol.60 (11), p.6451-6459

2016

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Insights into the Activity and Specificity of Trypanosoma cruzi trans-Sialidase from Molecular Dynamics Simulations

Biochemistry (Easton), 2013-05, Vol.52 (21), p.3740-3751

2013

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Biophysical and X-ray Crystallographic Analysis of Mps1 Kinase Inhibitor Complexes

Biochemistry (Easton), 2010-03, Vol.49 (8), p.1689-1701

2010

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Mechanism of a Standalone β‐Lactone Synthetase: New Continuous Assay for a Widespread ANL Superfamily Enzyme

Chembiochem : a European journal of chemical biology, 2019-07, Vol.20 (13), p.1701-1711

2019

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Global Virulence Regulators VsrAD and PhcA Control Secondary Metabolism in the Plant Pathogen Ralstonia solanacearum

Chembiochem : a European journal of chemical biology, 2009-11, Vol.10 (17), p.2730-2732

2009

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Tryptophan as a Molecular Shovel in the Glycosyl Transfer Activity of Trypanosoma cruzi Trans-sialidase

Biophysical journal, 2010-05, Vol.98 (9), p.L38-L40

2010

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Nitroarenes as Antitubercular Agents: Stereoelectronic Modulation to Mitigate Mutagenicity

ChemMedChem, 2016-02, Vol.11 (3), p.331-339

2016

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DprE1--from the discovery to the promising tuberculosis drug target

Current pharmaceutical design, 2014-01, Vol.20 (27), p.4379

2014

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Discovery of novel inhibitors of Trypanosoma cruzi trans-sialidase from in silico screening

Bioorganic & medicinal chemistry letters, 2009-02, Vol.19 (3), p.589-596

2009

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4‑Aminoquinolone Piperidine Amides: Noncovalent Inhibitors of DprE1 with Long Residence Time and Potent Antimycobacterial Activity

Journal of medicinal chemistry, 2014-06, Vol.57 (12), p.5419-5434

2014

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Benzoic acid and pyridine derivatives as inhibitors of Trypanosoma cruzi trans-sialidase

Bioorganic & medicinal chemistry, 2007-03, Vol.15 (5), p.2106-2119

2007

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Aryl Acid Adenylating Enzymes Involved in Siderophore Biosynthesis: Fluorescence Polarization Assay, Ligand Specificity, and Discovery of Non-nucleoside Inhibitors via High-Throughput Screening

Biochemistry (Easton), 2008-11, Vol.47 (45), p.11735-11749

2008

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Towards a new combination therapy for tuberculosis with next generation benzothiazinones

DprE1 Is a Vulnerable Tuberculosis Drug Target Due to Its Cell Wall Localization

Towards a new tuberculosis drug: pyridomycin – nature's isoniazid

2‑Carboxyquinoxalines Kill Mycobacterium tuberculosis through Noncovalent Inhibition of DprE1

Biochemical and Structural Characterization of Bisubstrate Inhibitors of BasE, the Self-Standing Nonribosomal Peptide Synthetase Adenylate-Forming Enzyme of Acinetobactin Synthesis

Fluorescent Benzothiazinone Analogues Efficiently and Selectively Label Dpre1 in Mycobacteria and Actinobacteria

Structural basis for benzothiazinone-mediated killing of Mycobacterium tuberculosis

Inhibition of Siderophore Biosynthesis in Mycobacterium tuberculosis with Nucleoside Bisubstrate Analogues: Structure−Activity Relationships of the Nucleobase Domain of 5′-O-[N-(Salicyl)sulfamoyl]adenosine

The 8-Pyrrole-Benzothiazinones Are Noncovalent Inhibitors of DprE1 from Mycobacterium tuberculosis

Downregulation of Ubiquitin-Specific Protease 15 (USP15) Does Not Provide Therapeutic Benefit in Experimental Mesial Temporal Lobe Epilepsy

Inhibition of Siderophore Biosynthesis by 2-Triazole Substituted Analogues of 5′-O-[N-(Salicyl)sulfamoyl]adenosine: Antibacterial Nucleosides Effective against Mycobacterium tuberculosis

Non-Nucleoside Inhibitors of BasE, an Adenylating Enzyme in the Siderophore Biosynthetic Pathway of the Opportunistic Pathogen Acinetobacter baumannii

Characterization of DprE1-Mediated Benzothiazinone Resistance in Mycobacterium tuberculosis

Insights into the Activity and Specificity of Trypanosoma cruzi trans-Sialidase from Molecular Dynamics Simulations

Discovery of benzothiazoles as antimycobacterial agents: Synthesis, structure–activity relationships and binding studies with Mycobacterium tuberculosis decaprenylphosphoryl-β-d-ribose 2′-oxidase

Biophysical and X-ray Crystallographic Analysis of Mps1 Kinase Inhibitor Complexes

Mechanism of a Standalone β‐Lactone Synthetase: New Continuous Assay for a Widespread ANL Superfamily Enzyme

Global Virulence Regulators VsrAD and PhcA Control Secondary Metabolism in the Plant Pathogen Ralstonia solanacearum

Tryptophan as a Molecular Shovel in the Glycosyl Transfer Activity of Trypanosoma cruzi Trans-sialidase

Nitroarenes as Antitubercular Agents: Stereoelectronic Modulation to Mitigate Mutagenicity

DprE1--from the discovery to the promising tuberculosis drug target

Discovery of novel inhibitors of Trypanosoma cruzi trans-sialidase from in silico screening

4‑Aminoquinolone Piperidine Amides: Noncovalent Inhibitors of DprE1 with Long Residence Time and Potent Antimycobacterial Activity

Benzoic acid and pyridine derivatives as inhibitors of Trypanosoma cruzi trans-sialidase

Aryl Acid Adenylating Enzymes Involved in Siderophore Biosynthesis: Fluorescence Polarization Assay, Ligand Specificity, and Discovery of Non-nucleoside Inhibitors via High-Throughput Screening

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