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Identification of novel isocytosine derivatives as xanthine oxidase inhibitors from a set of virtual screening hits

Bioorganic & medicinal chemistry, 2012-05, Vol.20 (9), p.2930-2939

2012

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Isocytosine-based inhibitors of xanthine oxidase: Design, synthesis, SAR, PK and in vivo efficacy in rat model of hyperuricemia

Bioorganic & medicinal chemistry letters, 2012-12, Vol.22 (24), p.7543-7546

2012

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Variable Sensitivity to Noxious Heat Is Mediated by Differential Expression of the CGRP Gene

Proceedings of the National Academy of Sciences - PNAS, 2005-09, Vol.102 (36), p.12938-12943

2005

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Progress in the discovery and development of small-molecule modulators of G-protein-coupled receptor 40 (GPR40/FFA1/FFAR1): an emerging target for type 2 diabetes

Expert opinion on therapeutic patents, 2009-02, Vol.19 (2), p.237-264

2009

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Discovery of a Novel Potent and Selective Calcium Release-Activated Calcium Channel Inhibitor: 2,6-Difluoro‑N‑(2′-methyl-3′-(4-methyl-5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)-[1,1′-biphenyl]-4-yl)benzamide. Structure–Activity Relationship and Preclinical Characterization

Journal of medicinal chemistry, 2021-12, Vol.64 (23), p.17004-17030

2021

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NO-NSAIDs: Gastric-sparing nitric oxide-releasable prodrugs of non-steroidal anti-inflammatory drugs

Bioorganic & medicinal chemistry letters, 2009-09, Vol.19 (18), p.5297-5301

2009

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Exploration of pyridine containing heteroaryl analogs of biaryl ureas as DGAT1 inhibitors

Bioorganic & medicinal chemistry letters, 2011-10, Vol.21 (19), p.5812-5817

2011

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The Melanocortin-1 Receptor Gene Mediates Female-Specific Mechanisms of Analgesia in Mice and Humans

Proceedings of the National Academy of Sciences - PNAS, 2003-04, Vol.100 (8), p.4867-4872

2003

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Synthesis and biological evaluation of isoxazole, oxazole, and oxadiazole containing heteroaryl analogs of biaryl ureas as DGAT1 inhibitors

European journal of medicinal chemistry, 2012-08, Vol.54, p.324-342

2012

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Lead optimization of isocytosine-derived xanthine oxidase inhibitors

Bioorganic & medicinal chemistry letters, 2013-02, Vol.23 (3), p.834-838

2013

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Gastric-sparing nitric oxide-releasable 'true' prodrugs of aspirin and naproxen

Bioorganic & medicinal chemistry letters, 2014-12, Vol.24 (24), p.5587-5592

2014

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Advancing health care via artificial intelligence: From concept to clinic

European journal of pharmacology, 2022-11, Vol.934, p.175320-175320, Article 175320

2022

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Discovery and development of selective PPARγ modulators as safe and effective antidiabetic agents

Expert opinion on investigational drugs, 2010-04, Vol.19 (4), p.489-512

2010

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APD668, a G protein-coupled receptor 119 agonist improves fat tolerance and attenuates fatty liver in high-trans fat diet induced steatohepatitis model in C57BL/6 mice

European journal of pharmacology, 2017-04, Vol.801, p.35-45

2017

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Montelukast Ameliorates Scopolamine-induced Alzheimer's Disease: Role on Cholinergic Neurotransmission, Antioxidant Defence System, Neuroinflammation and Expression of BDNF

CNS & neurological disorders drug targets, 2024-01, Vol.23 (8), p.1040-1055

2024

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Acute administration of GPR40 receptor agonist potentiates glucose-stimulated insulin secretion in vivo in the rat

Metabolism, clinical and experimental, 2009-03, Vol.58 (3), p.333-343

2009

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Targeting glucose-dependent insulinotropic polypeptide receptor for neurodegenerative disorders

Expert opinion on therapeutic targets, 2018-07, Vol.22 (7), p.615-628

2018

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Neuroprotective Effect of Saroglitazar on Scopolamine-Induced Alzheimer’s in Rats: Insights into the Underlying Mechanisms

ACS chemical neuroscience, 2023-09, Vol.14 (18), p.3444-3459

2023

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Co-administration of APD668, a G protein-coupled receptor 119 agonist and linagliptin, a DPPIV inhibitor, prevents progression of steatohepatitis in mice fed on a high trans-fat diet

Biochemical and biophysical research communications, 2018-01, Vol.495 (2), p.1608-1613

2018

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Discovery and pre-clinical characterization of a selective PI3Kδ inhibitor, LL-00071210 in rheumatoid arthritis

European journal of pharmacology, 2022-07, Vol.927, p.175054-175054, Article 175054

2022

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Prediction of volume of distribution in preclinical species and humans: application of simplified physiologically based algorithms

Xenobiotica, 2019-05, Vol.49 (5), p.528-539

2019

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Synthesis and therapeutic evaluation of pyridyl based novel mTOR inhibitors

Bioorganic & medicinal chemistry letters, 2009-06, Vol.19 (11), p.2949-2952

2009

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Prediction of Tissue-to-Plasma Ratios of Basic Compounds in Mice

European journal of drug metabolism and pharmacokinetics, 2017-10, Vol.42 (5), p.835-847

2017

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Combination of APD668, a G protein-coupled receptor 119 agonist with linagliptin, a DPPIV inhibitor, prevents progression of steatohepatitis in a murine model of non-alcoholic steatohepatitis with diabetes

Medical molecular morphology, 2019-03, Vol.52 (1), p.36-43

2019

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Prediction of Tumor-to-Plasma Ratios of Basic Compounds in Subcutaneous Xenograft Mouse Models

European journal of drug metabolism and pharmacokinetics, 2018-06, Vol.43 (3), p.331-346

2018

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Identification of novel isocytosine derivatives as xanthine oxidase inhibitors from a set of virtual screening hits

Isocytosine-based inhibitors of xanthine oxidase: Design, synthesis, SAR, PK and in vivo efficacy in rat model of hyperuricemia

Variable Sensitivity to Noxious Heat Is Mediated by Differential Expression of the CGRP Gene

Progress in the discovery and development of small-molecule modulators of G-protein-coupled receptor 40 (GPR40/FFA1/FFAR1): an emerging target for type 2 diabetes

Discovery of a Novel Potent and Selective Calcium Release-Activated Calcium Channel Inhibitor: 2,6-Difluoro‑N‑(2′-methyl-3′-(4-methyl-5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)-[1,1′-biphenyl]-4-yl)benzamide. Structure–Activity Relationship and Preclinical Characterization

NO-NSAIDs: Gastric-sparing nitric oxide-releasable prodrugs of non-steroidal anti-inflammatory drugs

Exploration of pyridine containing heteroaryl analogs of biaryl ureas as DGAT1 inhibitors

The Melanocortin-1 Receptor Gene Mediates Female-Specific Mechanisms of Analgesia in Mice and Humans

Synthesis and biological evaluation of isoxazole, oxazole, and oxadiazole containing heteroaryl analogs of biaryl ureas as DGAT1 inhibitors

Lead optimization of isocytosine-derived xanthine oxidase inhibitors

Gastric-sparing nitric oxide-releasable 'true' prodrugs of aspirin and naproxen

Advancing health care via artificial intelligence: From concept to clinic

Discovery and development of selective PPARγ modulators as safe and effective antidiabetic agents

APD668, a G protein-coupled receptor 119 agonist improves fat tolerance and attenuates fatty liver in high-trans fat diet induced steatohepatitis model in C57BL/6 mice

Montelukast Ameliorates Scopolamine-induced Alzheimer's Disease: Role on Cholinergic Neurotransmission, Antioxidant Defence System, Neuroinflammation and Expression of BDNF

Acute administration of GPR40 receptor agonist potentiates glucose-stimulated insulin secretion in vivo in the rat

Targeting glucose-dependent insulinotropic polypeptide receptor for neurodegenerative disorders

Neuroprotective Effect of Saroglitazar on Scopolamine-Induced Alzheimer’s in Rats: Insights into the Underlying Mechanisms

Co-administration of APD668, a G protein-coupled receptor 119 agonist and linagliptin, a DPPIV inhibitor, prevents progression of steatohepatitis in mice fed on a high trans-fat diet

Discovery and pre-clinical characterization of a selective PI3Kδ inhibitor, LL-00071210 in rheumatoid arthritis

Prediction of volume of distribution in preclinical species and humans: application of simplified physiologically based algorithms

Synthesis and therapeutic evaluation of pyridyl based novel mTOR inhibitors

Prediction of Tissue-to-Plasma Ratios of Basic Compounds in Mice

Combination of APD668, a G protein-coupled receptor 119 agonist with linagliptin, a DPPIV inhibitor, prevents progression of steatohepatitis in a murine model of non-alcoholic steatohepatitis with diabetes

Prediction of Tumor-to-Plasma Ratios of Basic Compounds in Subcutaneous Xenograft Mouse Models

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