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Advancing health care via artificial intelligence: From concept to clinic

European journal of pharmacology, 2022-11, Vol.934, p.175320-175320, Article 175320

2022

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Identification of novel isocytosine derivatives as xanthine oxidase inhibitors from a set of virtual screening hits

Bioorganic & medicinal chemistry, 2012-05, Vol.20 (9), p.2930-2939

2012

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Isocytosine-based inhibitors of xanthine oxidase: Design, synthesis, SAR, PK and in vivo efficacy in rat model of hyperuricemia

Bioorganic & medicinal chemistry letters, 2012-12, Vol.22 (24), p.7543-7546

2012

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Discovery and pre-clinical characterization of a selective PI3Kδ inhibitor, LL-00071210 in rheumatoid arthritis

European journal of pharmacology, 2022-07, Vol.927, p.175054-175054, Article 175054

2022

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APD668, a G protein-coupled receptor 119 agonist improves fat tolerance and attenuates fatty liver in high-trans fat diet induced steatohepatitis model in C57BL/6 mice

European journal of pharmacology, 2017-04, Vol.801, p.35-45

2017

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Discovery of a Novel Potent and Selective Calcium Release-Activated Calcium Channel Inhibitor: 2,6-Difluoro‑N‑(2′-methyl-3′-(4-methyl-5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)-[1,1′-biphenyl]-4-yl)benzamide. Structure–Activity Relationship and Preclinical Characterization

Journal of medicinal chemistry, 2021-12, Vol.64 (23), p.17004-17030

2021

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Co-administration of APD668, a G protein-coupled receptor 119 agonist and linagliptin, a DPPIV inhibitor, prevents progression of steatohepatitis in mice fed on a high trans-fat diet

Biochemical and biophysical research communications, 2018-01, Vol.495 (2), p.1608-1613

2018

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Targeting glucose-dependent insulinotropic polypeptide receptor for neurodegenerative disorders

Expert opinion on therapeutic targets, 2018-07, Vol.22 (7), p.615-628

2018

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Neuroprotective Effect of Saroglitazar on Scopolamine-Induced Alzheimer’s in Rats: Insights into the Underlying Mechanisms

ACS chemical neuroscience, 2023-09, Vol.14 (18), p.3444-3459

2023

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Lead optimization of isocytosine-derived xanthine oxidase inhibitors

Bioorganic & medicinal chemistry letters, 2013-02, Vol.23 (3), p.834-838

2013

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Prediction of volume of distribution in preclinical species and humans: application of simplified physiologically based algorithms

Xenobiotica, 2019-05, Vol.49 (5), p.528-539

2019

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Progress in the discovery and development of small-molecule modulators of G-protein-coupled receptor 40 (GPR40/FFA1/FFAR1): an emerging target for type 2 diabetes

Expert opinion on therapeutic patents, 2009-02, Vol.19 (2), p.237-264

2009

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Gastric-sparing nitric oxide-releasable 'true' prodrugs of aspirin and naproxen

Bioorganic & medicinal chemistry letters, 2014-12, Vol.24 (24), p.5587-5592

2014

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The Melanocortin-1 Receptor Gene Mediates Female-Specific Mechanisms of Analgesia in Mice and Humans

Proceedings of the National Academy of Sciences - PNAS, 2003-04, Vol.100 (8), p.4867-4872

2003

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Variable Sensitivity to Noxious Heat Is Mediated by Differential Expression of the CGRP Gene

Proceedings of the National Academy of Sciences - PNAS, 2005-09, Vol.102 (36), p.12938-12943

2005

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Discovery and development of selective PPARγ modulators as safe and effective antidiabetic agents

Expert opinion on investigational drugs, 2010-04, Vol.19 (4), p.489-512

2010

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Exploration of pyridine containing heteroaryl analogs of biaryl ureas as DGAT1 inhibitors

Bioorganic & medicinal chemistry letters, 2011-10, Vol.21 (19), p.5812-5817

2011

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Synthesis and biological evaluation of isoxazole, oxazole, and oxadiazole containing heteroaryl analogs of biaryl ureas as DGAT1 inhibitors

European journal of medicinal chemistry, 2012-08, Vol.54, p.324-342

2012

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Combination of APD668, a G protein-coupled receptor 119 agonist with linagliptin, a DPPIV inhibitor, prevents progression of steatohepatitis in a murine model of non-alcoholic steatohepatitis with diabetes

Medical molecular morphology, 2019-03, Vol.52 (1), p.36-43

2019

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NO-NSAIDs: Gastric-sparing nitric oxide-releasable prodrugs of non-steroidal anti-inflammatory drugs

Bioorganic & medicinal chemistry letters, 2009-09, Vol.19 (18), p.5297-5301

2009

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Bilateral quinolinic acid-induced lipid peroxidation, decreased striatal monoamine levels and neurobehavioral deficits are ameliorated by GIP receptor agonist D-Ala2GIP in rat model of Huntington's disease

European journal of pharmacology, 2018-06, Vol.828, p.31-41

2018

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Bilateral quinolinic acid-induced lipid peroxidation, decreased striatal monoamine levels and neurobehavioral deficits are ameliorated by GIP receptor agonist D-Ala 2 GIP in rat model of Huntington's disease

European journal of pharmacology, 2018-06, Vol.828, p.31-41

2018

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Prediction of Tissue-to-Plasma Ratios of Basic Compounds in Mice

European journal of drug metabolism and pharmacokinetics, 2017-10, Vol.42 (5), p.835-847

2017

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Effect of D-Ala2GIP, a stable GIP receptor agonist on MPTP-induced neuronal impairments in mice

European journal of pharmacology, 2017-06, Vol.804, p.38-45

2017

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Effect of D-Ala 2 GIP, a stable GIP receptor agonist on MPTP-induced neuronal impairments in mice

European journal of pharmacology, 2017-06, Vol.804, p.38-45

2017

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Advancing health care via artificial intelligence: From concept to clinic

Identification of novel isocytosine derivatives as xanthine oxidase inhibitors from a set of virtual screening hits

Isocytosine-based inhibitors of xanthine oxidase: Design, synthesis, SAR, PK and in vivo efficacy in rat model of hyperuricemia

Discovery and pre-clinical characterization of a selective PI3Kδ inhibitor, LL-00071210 in rheumatoid arthritis

APD668, a G protein-coupled receptor 119 agonist improves fat tolerance and attenuates fatty liver in high-trans fat diet induced steatohepatitis model in C57BL/6 mice

Discovery of a Novel Potent and Selective Calcium Release-Activated Calcium Channel Inhibitor: 2,6-Difluoro‑N‑(2′-methyl-3′-(4-methyl-5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)-[1,1′-biphenyl]-4-yl)benzamide. Structure–Activity Relationship and Preclinical Characterization

Co-administration of APD668, a G protein-coupled receptor 119 agonist and linagliptin, a DPPIV inhibitor, prevents progression of steatohepatitis in mice fed on a high trans-fat diet

Targeting glucose-dependent insulinotropic polypeptide receptor for neurodegenerative disorders

Neuroprotective Effect of Saroglitazar on Scopolamine-Induced Alzheimer’s in Rats: Insights into the Underlying Mechanisms

Lead optimization of isocytosine-derived xanthine oxidase inhibitors

Prediction of volume of distribution in preclinical species and humans: application of simplified physiologically based algorithms

Progress in the discovery and development of small-molecule modulators of G-protein-coupled receptor 40 (GPR40/FFA1/FFAR1): an emerging target for type 2 diabetes

Gastric-sparing nitric oxide-releasable 'true' prodrugs of aspirin and naproxen

The Melanocortin-1 Receptor Gene Mediates Female-Specific Mechanisms of Analgesia in Mice and Humans

Variable Sensitivity to Noxious Heat Is Mediated by Differential Expression of the CGRP Gene

Discovery and development of selective PPARγ modulators as safe and effective antidiabetic agents

Exploration of pyridine containing heteroaryl analogs of biaryl ureas as DGAT1 inhibitors

Synthesis and biological evaluation of isoxazole, oxazole, and oxadiazole containing heteroaryl analogs of biaryl ureas as DGAT1 inhibitors

Combination of APD668, a G protein-coupled receptor 119 agonist with linagliptin, a DPPIV inhibitor, prevents progression of steatohepatitis in a murine model of non-alcoholic steatohepatitis with diabetes

NO-NSAIDs: Gastric-sparing nitric oxide-releasable prodrugs of non-steroidal anti-inflammatory drugs

Bilateral quinolinic acid-induced lipid peroxidation, decreased striatal monoamine levels and neurobehavioral deficits are ameliorated by GIP receptor agonist D-Ala2GIP in rat model of Huntington's disease

Bilateral quinolinic acid-induced lipid peroxidation, decreased striatal monoamine levels and neurobehavioral deficits are ameliorated by GIP receptor agonist D-Ala 2 GIP in rat model of Huntington's disease

Prediction of Tissue-to-Plasma Ratios of Basic Compounds in Mice

Effect of D-Ala2GIP, a stable GIP receptor agonist on MPTP-induced neuronal impairments in mice

Effect of D-Ala 2 GIP, a stable GIP receptor agonist on MPTP-induced neuronal impairments in mice

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