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JAK1 activates STAT3 activity in non-small-cell lung cancer cells and IL-6 neutralizing antibodies can suppress JAK1-STAT3 signaling

Molecular cancer therapeutics, 2011-03, Vol.10 (3), p.481-494

2011

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Tumor-associated macrophages promote invasion while retaining Fc-dependent anti-tumor function

The Journal of immunology (1950), 2012-12, Vol.189 (11), p.5457-5466

2012

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Down-regulation of Suppressor of Cytokine Signaling-3 Causes Prostate Cancer Cell Death through Activation of the Extrinsic and Intrinsic Apoptosis Pathways

Cancer research (Chicago, Ill.), 2009-09, Vol.69 (18), p.7375-7384

2009

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Inhibition of Interleukin-6 Signaling with CNTO 328 Enhances the Activity of Bortezomib in Preclinical Models of Multiple Myeloma

Clinical cancer research, 2007-11, Vol.13 (21), p.6469-6478

2007

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CNTO 328, a monoclonal antibody to IL‐6, inhibits human tumor‐induced cachexia in nude mice

International journal of cancer, 2004-09, Vol.111 (4), p.592-595

2004

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Phase I Evaluation of a Fully Human Anti–αv Integrin Monoclonal Antibody (CNTO 95) in Patients with Advanced Solid Tumors

Clinical cancer research, 2007-04, Vol.13 (7), p.2128-2135

2007

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Circulating Human Interleukin-8 as an Indicator of Cancer Progression in a Nude Rat Orthotopic Human Non–Small Cell Lung Carcinoma Model

Cancer epidemiology, biomarkers & prevention, 2008-08, Vol.17 (8), p.2180-2187

2008

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Differential regulation of matrix metalloproteinase‐9, tissue inhibitor of metalloproteinase‐1 (TIMP‐1) and TIMP‐2 expression in co‐cultures of prostate cancer and stromal cells

International journal of cancer, 2001-08, Vol.93 (4), p.507-515

2001

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Targeted inhibition of interleukin‐6 with CNTO 328 sensitizes pre‐clinical models of multiple myeloma to dexamethasone‐mediated cell death

British journal of haematology, 2009-05, Vol.145 (4), p.481-490

2009

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Absence of Adverse Effects in Cynomolgus Macaques Treated with CNTO 95, a Fully Human Anti-αv Integrin Monoclonal Antibody, Despite Widespread Tissue Binding

Clinical cancer research, 2005-10, Vol.11 (19), p.6959-6965

2005

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Blockade of interleukin‐6 signalling with siltuximab enhances melphalan cytotoxicity in preclinical models of multiple myeloma

British journal of haematology, 2011-03, Vol.152 (5), p.579-592

2011

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Cyclophosphamide Creates a Receptive Microenvironment for Prostate Cancer Skeletal Metastasis

Cancer research (Chicago, Ill.), 2012-05, Vol.72 (10), p.2522-2532

2012

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Inhibition of interleukin-6 with CNTO328, an anti-interleukin-6 monoclonal antibody, inhibits conversion of androgen-dependent prostate cancer to an androgen-independent phenotype in orchiectomized mice

Cancer research (Chicago, Ill.), 2006-03, Vol.66 (6), p.3087-3095

2006

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Matrix Metalloproteinase Activity, Bone Matrix Turnover, and Tumor Cell Proliferation in Prostate Cancer Bone Metastasis

JNCI : Journal of the National Cancer Institute, 2002-01, Vol.94 (1), p.17-25

2002

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Alpha-v Integrins as Therapeutic Targets in Oncology

Cancer investigation, 2007-10, Vol.25 (7), p.632-646

2007

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Mcl-1 is regulated by IL-6 and mediates the survival activity of the cytokine in a model of late stage prostate carcinoma

Advances in experimental medicine and biology, 2008, Vol.617, p.547

2008

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Anti-integrin monoclonal antibody CNTO 95 enhances the therapeutic efficacy of fractionated radiation therapy in vivo

Molecular cancer therapeutics, 2008-06, Vol.7 (6), p.1569-1578

2008

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Severe combined immunodeficient-hu model of human prostate cancer metastasis to human bone

Cancer research (Chicago, Ill.), 1999-04, Vol.59 (8), p.1987-1993

1999

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Regulation of growth of prostate cancer cells selected in the presence of interleukin-6 by the anti-interleukin-6 antibody CNTO 328

The Prostate, 2006-12, Vol.66 (16), p.1744-1752

2006

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Role for β3 integrins in human melanoma growth and survival

International journal of cancer, 2002-09, Vol.101 (2), p.156-167

2002

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Membrane Type 1-Matrix Metalloproteinase (MT1-MMP) and MMP-2 Immunolocalization in Human Prostate: Change in Cellular Localization Associated with High-Grade Prostatic Intraepithelial Neoplasia

Clinical cancer research, 1999-12, Vol.5 (12), p.4105-4110

1999

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TIMP-2 Growth-Stimulatory Activity: A Concentration- and Cell Type-Specific Response in the Presence of Insulin

Experimental cell research, 1996-04, Vol.224 (1), p.110-115

1996

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Six-pin halo fixation and the resulting prevalence of pin-site complications

Journal of bone and joint surgery. American volume, 2001-03, Vol.83 (3), p.377-382

2001

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Scalp burns from halo pins following magnetic resonance imaging. Case illustration

Journal of neurosurgery, 2003-07, Vol.99 (1), p.186

2003

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Proliferation of prostate cancer cells in the bone marrow predicts recurrence in patients with localized prostate cancer

The Prostate, 2001-12, Vol.49 (4), p.235-242

2001

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JAK1 activates STAT3 activity in non-small-cell lung cancer cells and IL-6 neutralizing antibodies can suppress JAK1-STAT3 signaling

Tumor-associated macrophages promote invasion while retaining Fc-dependent anti-tumor function

Down-regulation of Suppressor of Cytokine Signaling-3 Causes Prostate Cancer Cell Death through Activation of the Extrinsic and Intrinsic Apoptosis Pathways

Inhibition of Interleukin-6 Signaling with CNTO 328 Enhances the Activity of Bortezomib in Preclinical Models of Multiple Myeloma

CNTO 328, a monoclonal antibody to IL‐6, inhibits human tumor‐induced cachexia in nude mice

Phase I Evaluation of a Fully Human Anti–αv Integrin Monoclonal Antibody (CNTO 95) in Patients with Advanced Solid Tumors

Circulating Human Interleukin-8 as an Indicator of Cancer Progression in a Nude Rat Orthotopic Human Non–Small Cell Lung Carcinoma Model

Differential regulation of matrix metalloproteinase‐9, tissue inhibitor of metalloproteinase‐1 (TIMP‐1) and TIMP‐2 expression in co‐cultures of prostate cancer and stromal cells

Targeted inhibition of interleukin‐6 with CNTO 328 sensitizes pre‐clinical models of multiple myeloma to dexamethasone‐mediated cell death

Absence of Adverse Effects in Cynomolgus Macaques Treated with CNTO 95, a Fully Human Anti-αv Integrin Monoclonal Antibody, Despite Widespread Tissue Binding

Blockade of interleukin‐6 signalling with siltuximab enhances melphalan cytotoxicity in preclinical models of multiple myeloma

Cyclophosphamide Creates a Receptive Microenvironment for Prostate Cancer Skeletal Metastasis

Inhibition of interleukin-6 with CNTO328, an anti-interleukin-6 monoclonal antibody, inhibits conversion of androgen-dependent prostate cancer to an androgen-independent phenotype in orchiectomized mice

Matrix Metalloproteinase Activity, Bone Matrix Turnover, and Tumor Cell Proliferation in Prostate Cancer Bone Metastasis

Alpha-v Integrins as Therapeutic Targets in Oncology

Mcl-1 is regulated by IL-6 and mediates the survival activity of the cytokine in a model of late stage prostate carcinoma

Anti-integrin monoclonal antibody CNTO 95 enhances the therapeutic efficacy of fractionated radiation therapy in vivo

Severe combined immunodeficient-hu model of human prostate cancer metastasis to human bone

Regulation of growth of prostate cancer cells selected in the presence of interleukin-6 by the anti-interleukin-6 antibody CNTO 328

Role for β3 integrins in human melanoma growth and survival

Membrane Type 1-Matrix Metalloproteinase (MT1-MMP) and MMP-2 Immunolocalization in Human Prostate: Change in Cellular Localization Associated with High-Grade Prostatic Intraepithelial Neoplasia

TIMP-2 Growth-Stimulatory Activity: A Concentration- and Cell Type-Specific Response in the Presence of Insulin

Six-pin halo fixation and the resulting prevalence of pin-site complications

Scalp burns from halo pins following magnetic resonance imaging. Case illustration

Proliferation of prostate cancer cells in the bone marrow predicts recurrence in patients with localized prostate cancer

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