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VHH Nanobody Versatility against Pentameric Ligand-Gated Ion Channels

Journal of medicinal chemistry, 2024-06, Vol.67 (11), p.8502-8518

2024

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Fumarate as positive modulator of allosteric transitions in the pentameric ligand‐gated ion channel GLIC: requirement of an intact vestibular pocket

The Journal of physiology, 2023-06, Vol.601 (12), p.2447-2472

2023

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Crystal structures of a pentameric ion channel gated by alkaline pH show a widely open pore and identify a cavity for modulation

Proceedings of the National Academy of Sciences - PNAS, 2018-04, Vol.115 (17), p.E3959-E3968

2018

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Emerging Molecular Mechanisms of Signal Transduction in Pentameric Ligand-Gated Ion Channels

Neuron (Cambridge, Mass.), 2016-05, Vol.90 (3), p.452-470

2016

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Crystal structures of a pentameric ligand-gated ion channel provide a mechanism for activation

Proceedings of the National Academy of Sciences - PNAS, 2014-01, Vol.111 (3), p.966-971

2014

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Creating an α7 nicotinic acetylcholine recognition domain from the acetylcholine-binding protein: crystallographic and ligand selectivity analyses

The Journal of biological chemistry, 2011-12, Vol.286 (49), p.42555-42565

2011

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Full mutational mapping of titratable residues helps to identify proton-sensors involved in the control of channel gating in the Gloeobacter violaceus pentameric ligand-gated ion channel

PLoS biology, 2017-12, Vol.15 (12), p.e2004470-e2004470

2017

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Generation of Candidate Ligands for Nicotinic Acetylcholine Receptors via in situ Click Chemistry with a Soluble Acetylcholine Binding Protein Template

Journal of the American Chemical Society, 2012-04, Vol.134 (15), p.6732-6740

2012

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Short‐chain mono‐carboxylates as negative modulators of allosteric transitions in Gloeobacter violaceus ligand‐gated ion channel, and impact of a pre‐β5 strand (Loop Ω) double mutation on crotonate, not butyrate effect

Physiological reports, 2024-02, Vol.12 (3), p.e15916-n/a

2024

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Fumarate as positive modulator of allosteric transitions in the pentameric ligand-gated ion channel GLIC: Requirement of an intact vestibular pocket: Fumarate as positive allosteric modulator of GLIC

The Journal of physiology, 2023

2023

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Characterizing Ligand-Gated Ion Channel Receptors with Genetically Encoded Ca++ Sensors

PloS one, 2011-01, Vol.6 (1), p.e16519

2011

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Creating an α7 Nicotinic Acetylcholine Recognition Domain from the Acetylcholine-binding Protein

The Journal of biological chemistry, 2011-12, Vol.286 (49), p.42555-42565

2011

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Generation of nanobodies acting as silent and positive allosteric modulators of the α7 nicotinic acetylcholine receptor

Cellular and molecular life sciences : CMLS, 2023-06, Vol.80 (6), p.164-164, Article 164

2023

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The effect of crebanine on memory and cognition impairment via the alpha-7 nicotinic acetylcholine receptor

Life sciences (1973), 2012-08, Vol.91 (3-4), p.107-114

2012

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Validating the Acetylcholine Binding Protein's Conversion Potential to a Human Nicotinic Acetylcholine Receptor

The FASEB journal, 2010-04, Vol.24 (S1), p.579.1-579.1

2010

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Synthesis of selective agonists for the α7 nicotinic acetylcholine receptor with in situ click-chemistry on acetylcholine-binding protein templates

Molecular pharmacology, 2012-10, Vol.82 (4), p.687-699

2012

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Alpha‐7 Nicotinic Acetylcholine Receptor (nAChR) Characteristics on the Acetylcholine Binding Protein

The FASEB journal, 2009-04, Vol.23 (S1)

2009

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Elucidating Proton Sensitivity and Activation in the Gloeobacter Violaceus Ligand-Gated Ion Channel

Biophysical journal, 2016-02, Vol.110 (3), p.456a-456a

2016

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Characterizing ligand-gated ion channel receptors with genetically encoded Ca2++ sensors

PloS one, 2011-01, Vol.6 (1), p.e16519

2011

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Structure‐Activity Considerations for Heteroaromatic nortropeines and N‐methyltropeines with Nicotinic Acetylcholine Receptor (nAChR) Subtypes and a Serotonin Receptor (5HT3A)

The FASEB journal, 2013-04, Vol.27 (S1)

2013

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Characterizing Ligand-Gated Ion Channel Receptors with Genetically Encoded Ca.sup.++ Sensors

PloS one, 2011-01, Vol.6 (1), p.e16519

2011

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Uncommon Features of a Novel γ-Proteobacterial Pentameric Ligand-Gated Ion Channel Revealed by its Crystal Structure

Biophysical journal, 2017-02, Vol.112 (3), p.321a-321a

2017

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A structure‐guided design strategy to develop ligands with subtype selectivity for human nicotinic acetylcholine receptors

The FASEB journal, 2009-04, Vol.23 (S1)

2009

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Derivatives of 1,2,3‐triazole lead found to be selective and potent agonists at the α7 nicotinic acetylcholine receptor (1059.8)

The FASEB journal, 2014-04, Vol.28 (S1), p.n/a

2014

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The role of the β9–10 linker in nicotinic acetylcholine receptor selectivity

The FASEB journal, 2012-04, Vol.26 (S1)

2012

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VHH Nanobody Versatility against Pentameric Ligand-Gated Ion Channels

Fumarate as positive modulator of allosteric transitions in the pentameric ligand‐gated ion channel GLIC: requirement of an intact vestibular pocket

Crystal structures of a pentameric ion channel gated by alkaline pH show a widely open pore and identify a cavity for modulation

Emerging Molecular Mechanisms of Signal Transduction in Pentameric Ligand-Gated Ion Channels

Crystal structures of a pentameric ligand-gated ion channel provide a mechanism for activation

Creating an α7 nicotinic acetylcholine recognition domain from the acetylcholine-binding protein: crystallographic and ligand selectivity analyses

Full mutational mapping of titratable residues helps to identify proton-sensors involved in the control of channel gating in the Gloeobacter violaceus pentameric ligand-gated ion channel

Generation of Candidate Ligands for Nicotinic Acetylcholine Receptors via in situ Click Chemistry with a Soluble Acetylcholine Binding Protein Template

Short‐chain mono‐carboxylates as negative modulators of allosteric transitions in Gloeobacter violaceus ligand‐gated ion channel, and impact of a pre‐β5 strand (Loop Ω) double mutation on crotonate, not butyrate effect

Fumarate as positive modulator of allosteric transitions in the pentameric ligand-gated ion channel GLIC: Requirement of an intact vestibular pocket: Fumarate as positive allosteric modulator of GLIC

Characterizing Ligand-Gated Ion Channel Receptors with Genetically Encoded Ca++ Sensors

Creating an α7 Nicotinic Acetylcholine Recognition Domain from the Acetylcholine-binding Protein

Generation of nanobodies acting as silent and positive allosteric modulators of the α7 nicotinic acetylcholine receptor

The effect of crebanine on memory and cognition impairment via the alpha-7 nicotinic acetylcholine receptor

Validating the Acetylcholine Binding Protein's Conversion Potential to a Human Nicotinic Acetylcholine Receptor

Synthesis of selective agonists for the α7 nicotinic acetylcholine receptor with in situ click-chemistry on acetylcholine-binding protein templates

Alpha‐7 Nicotinic Acetylcholine Receptor (nAChR) Characteristics on the Acetylcholine Binding Protein

Elucidating Proton Sensitivity and Activation in the Gloeobacter Violaceus Ligand-Gated Ion Channel

Characterizing ligand-gated ion channel receptors with genetically encoded Ca2++ sensors

Structure‐Activity Considerations for Heteroaromatic nortropeines and N‐methyltropeines with Nicotinic Acetylcholine Receptor (nAChR) Subtypes and a Serotonin Receptor (5HT3A)

Characterizing Ligand-Gated Ion Channel Receptors with Genetically Encoded Ca.sup.++ Sensors

Uncommon Features of a Novel γ-Proteobacterial Pentameric Ligand-Gated Ion Channel Revealed by its Crystal Structure

A structure‐guided design strategy to develop ligands with subtype selectivity for human nicotinic acetylcholine receptors

Derivatives of 1,2,3‐triazole lead found to be selective and potent agonists at the α7 nicotinic acetylcholine receptor (1059.8)

The role of the β9–10 linker in nicotinic acetylcholine receptor selectivity

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