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Role of itraconazole metabolites in CYP3A4 inhibition

Drug metabolism and disposition, 2004-10, Vol.32 (10), p.1121-1131

2004

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Stereoselective Formation and Metabolism of 4-Hydroxy-Retinoic Acid Enantiomers by Cytochrome P450 Enzymes

The Journal of biological chemistry, 2012-12, Vol.287 (50), p.42223-42232

2012

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Tian ma, an ancient Chinese herb, offers new options for the treatment of epilepsy and other conditions

Epilepsy & behavior, 2006-03, Vol.8 (2), p.376-383

2006

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Stereospecific metabolism of itraconazole by CYP3A4: dioxolane ring scission of azole antifungals

Drug metabolism and disposition, 2012-03, Vol.40 (3), p.426-435

2012

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Sequential metabolism of secondary alkyl amines to metabolic-intermediate complexes: opposing roles for the secondary hydroxylamine and primary amine metabolites of desipramine, (s)-fluoxetine, and N-desmethyldiltiazem

Drug metabolism and disposition, 2010-06, Vol.38 (6), p.963-972

2010

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Validated HPLC-MS/MS Method To Quantify Low Levels of Domoic Acid in Plasma and Urine after Subacute Exposure

ACS omega, 2018-09, Vol.3 (9), p.12079-12088

2018

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Induction of CYP26A1 by metabolites of retinoic acid: evidence that CYP26A1 is an important enzyme in the elimination of active retinoids

Molecular pharmacology, 2015-03, Vol.87 (3), p.430-441

2015

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Stereochemical aspects of itraconazole metabolism in vitro and in vivo

Drug metabolism and disposition, 2006-04, Vol.34 (4), p.583-590

2006

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Comparison of the function and expression of CYP26A1 and CYP26B1, the two retinoic acid hydroxylases

Biochemical pharmacology, 2012-01, Vol.83 (1), p.149-163

2012

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Expression and functional characterization of cytochrome P450 26A1, a retinoic acid hydroxylase

Biochemical pharmacology, 2009-01, Vol.77 (2), p.258-268

2009

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Stereoselective inhibition of CYP2C19 and CYP3A4 by fluoxetine and its metabolite: implications for risk assessment of multiple time-dependent inhibitor systems

Drug metabolism and disposition, 2013-12, Vol.41 (12), p.2056-2065

2013

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Efficient Syntheses of Vitamin K Chain-Shortened Acid Metabolites

Synthesis (Stuttgart), 2015-04, Vol.47 (7), p.944-948

2015

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Identification and Structural Characterization of Three New Metabolites of Bupropion in Humans

ACS medicinal chemistry letters, 2016-08, Vol.7 (8), p.791-796

2016

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Substrate specificity and ligand interactions of CYP26A1, the human liver retinoic acid hydroxylase

Molecular pharmacology, 2011-08, Vol.80 (2), p.228-239

2011

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Metabolism of Diltiazem: A Short Efficient Synthesis of N,N-Didesmethyldiltiazem - An Important Product of N-Demethylation

Synthesis (Stuttgart), 2011-02, Vol.2011 (4), p.553-554

2011

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Importance of amine pKa and distribution coefficient in the metabolism of fluorinated propranolol derivatives. Preparation, identification of metabolite regioisomers, and metabolism by CYP2D6

Drug metabolism and disposition, 2001-11, Vol.29 (11), p.1377

2001

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Differential inactivation mechanism and covalent adduct formation of ALDH1A1 and ALDH1A2 by WIN18,446

The FASEB journal, 2018-04, Vol.32 (S1), p.833.10-833.10

2018

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Isothiocyanate-Substituted .kappa.-Selective Opioid Receptor Ligands Derived from N-Methyl-N-[(1S)-1-phenyl-2-(1-pyrrolidinyl)ethyl]phenylacetamide

Journal of medicinal chemistry, 1994-09, Vol.37 (18), p.2856-2864

1994

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Importance of amine pKa and distribution coefficient in the metabolism of fluorinated propranolol analogs: metabolism by CYP1A2

Drug metabolism and disposition, 2001-11, Vol.29 (11), p.1389

2001

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Stereospecific synthesis of the enantiomers of verapamil and gallopamil

Journal of organic chemistry, 1987-04, Vol.52 (7), p.1309-1315

1987

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Contribution of Itraconazole Metabolites to Inhibition of CYP3A4 In Vivo

Clinical pharmacology and therapeutics, 2008-01, Vol.83 (1), p.77-85

2008

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Absolute configuration of glycerol derivatives. 5. Oxprenolol enantiomers

Journal of organic chemistry, 1978-09, Vol.43 (19), p.3641-3645

1978

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Absolute configuration of glycerol derivatives. 3. Synthesis and Cupra A circular dichroism spectra of some chiral 3-aryloxy-1,2-propanediols and 3-aryloxy-1-amino-2-propanols

Journal of organic chemistry, 1977-03, Vol.42 (6), p.1006-1012

1977

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(E)- and (Z)-7-Arylidenenaltrexones: Synthesis and Opioid Receptor Radioligand Displacement Assays

Journal of medicinal chemistry, 1997-02, Vol.40 (5), p.749-753

1997

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Absolute configuration of glycerol derivatives. 4. Synthesis and pharmacological activity of chiral 2-alkylaminomethylbenzodioxans, competitive .alpha.-adrenergic antagonists

Journal of medicinal chemistry, 1977-07, Vol.20 (7), p.880-885

1977

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Role of itraconazole metabolites in CYP3A4 inhibition

Stereoselective Formation and Metabolism of 4-Hydroxy-Retinoic Acid Enantiomers by Cytochrome P450 Enzymes

Tian ma, an ancient Chinese herb, offers new options for the treatment of epilepsy and other conditions

Stereospecific metabolism of itraconazole by CYP3A4: dioxolane ring scission of azole antifungals

Sequential metabolism of secondary alkyl amines to metabolic-intermediate complexes: opposing roles for the secondary hydroxylamine and primary amine metabolites of desipramine, (s)-fluoxetine, and N-desmethyldiltiazem

Validated HPLC-MS/MS Method To Quantify Low Levels of Domoic Acid in Plasma and Urine after Subacute Exposure

Induction of CYP26A1 by metabolites of retinoic acid: evidence that CYP26A1 is an important enzyme in the elimination of active retinoids

Stereochemical aspects of itraconazole metabolism in vitro and in vivo

Comparison of the function and expression of CYP26A1 and CYP26B1, the two retinoic acid hydroxylases

Expression and functional characterization of cytochrome P450 26A1, a retinoic acid hydroxylase

Stereoselective inhibition of CYP2C19 and CYP3A4 by fluoxetine and its metabolite: implications for risk assessment of multiple time-dependent inhibitor systems

Efficient Syntheses of Vitamin K Chain-Shortened Acid Metabolites

Identification and Structural Characterization of Three New Metabolites of Bupropion in Humans

Substrate specificity and ligand interactions of CYP26A1, the human liver retinoic acid hydroxylase

Metabolism of Diltiazem: A Short Efficient Synthesis of N,N-Didesmethyldiltiazem - An Important Product of N-Demethylation

Importance of amine pKa and distribution coefficient in the metabolism of fluorinated propranolol derivatives. Preparation, identification of metabolite regioisomers, and metabolism by CYP2D6

Differential inactivation mechanism and covalent adduct formation of ALDH1A1 and ALDH1A2 by WIN18,446

Isothiocyanate-Substituted .kappa.-Selective Opioid Receptor Ligands Derived from N-Methyl-N-[(1S)-1-phenyl-2-(1-pyrrolidinyl)ethyl]phenylacetamide

Importance of amine pKa and distribution coefficient in the metabolism of fluorinated propranolol analogs: metabolism by CYP1A2

Stereospecific synthesis of the enantiomers of verapamil and gallopamil

Contribution of Itraconazole Metabolites to Inhibition of CYP3A4 In Vivo

Absolute configuration of glycerol derivatives. 5. Oxprenolol enantiomers

Absolute configuration of glycerol derivatives. 3. Synthesis and Cupra A circular dichroism spectra of some chiral 3-aryloxy-1,2-propanediols and 3-aryloxy-1-amino-2-propanols

(E)- and (Z)-7-Arylidenenaltrexones: Synthesis and Opioid Receptor Radioligand Displacement Assays

Absolute configuration of glycerol derivatives. 4. Synthesis and pharmacological activity of chiral 2-alkylaminomethylbenzodioxans, competitive .alpha.-adrenergic antagonists

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