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"Scaffold-Hopping" by Topological Pharmacophore Search: A Contribution to Virtual Screening

Angewandte Chemie (International ed.), 1999-10, Vol.38 (19), p.2894-2896

1999

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Development of a Virtual Screening Method for Identification of “Frequent Hitters” in Compound Libraries

Journal of medicinal chemistry, 2002-01, Vol.45 (1), p.137-142

2002

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Challenges and Rewards in Medicinal Chemistry Targeting Cardiovascular and Metabolic Diseases

Chimia, 2015-01, Vol.69 (7-8), p.407

2015

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Stepwise Design of γ‑Secretase Modulators with an Advanced Profile by Judicious Coordinated Structural Replacements and an Unconventional Phenyl Ring Bioisostere

Journal of medicinal chemistry, 2020-08, Vol.63 (15), p.8534-8553

2020

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A Real-World Perspective on Molecular Design

Journal of medicinal chemistry, 2016-05, Vol.59 (9), p.4087-4102

2016

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Discovery of RO7185876, a Highly Potent γ-Secretase Modulator (GSM) as a Potential Treatment for Alzheimer’s Disease

ACS medicinal chemistry letters, 2020-06, Vol.11 (6), p.1257-1268

2020

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Design and synthesis of selective, dual fatty acid binding protein 4 and 5 inhibitors

Bioorganic & medicinal chemistry letters, 2016-10, Vol.26 (20), p.5092-5097

2016

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A Real-World Perspective on Molecular Design: Miniperspective

Journal of medicinal chemistry, 2016-05, Vol.59 (9), p.4087-4102

2016

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Novel and potent NPY5 receptor antagonists derived from virtual screening and iterative parallel chemistry design

Bioorganic & medicinal chemistry letters, 2005-03, Vol.15 (6), p.1599-1603

2005

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Benzodioxoles: Novel Cannabinoid-1 Receptor Inverse Agonists for the Treatment of Obesity

Journal of medicinal chemistry, 2008-04, Vol.51 (7), p.2115-2127

2008

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Virtual Screening for Bioactive Molecules by Evolutionary De Novo Design

Angewandte Chemie (International ed.), 2000-11, Vol.39 (22), p.4130-4133

2000

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Ro 61-1790, a new hydrosoluble endothelin antagonist: general pharmacology and effects on experimental cerebral vasospasm

The Journal of pharmacology and experimental therapeutics, 1997-12, Vol.283 (3), p.1110

1997

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Channels and transporters. Mini-symposium of the Division of Medicinal Chemistry (DMC) of the Swiss Chemical Society (SCS) at the Department of Chemistry, University of Basel, May 27, 2010

Chimia, 2010, Vol.64 (9), p.662

2010

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Isomeric thiazole derivatives as ligands for the neuropeptide Y5 receptor

Bioorganic & medicinal chemistry letters, 2005-07, Vol.15 (14), p.3446-3449

2005

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Establishment of robust functional assays for the characterization of neuropeptide Y (NPY) receptors: identification of 3-(5-benzoyl-thiazol-2-ylamino)-benzonitrile as selective NPY type 5 receptor antagonist

Neuropharmacology, 2005-06, Vol.48 (7), p.1043-1055

2005

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Aminothiazole Derivatives as Neuropeptide Y5 Receptor Ligands: Finding the Balance between Affinity and Physicochemical Properties

ChemMedChem, 2006-01, Vol.1 (1), p.45-48

2006

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Grundgerüstwechsel"︁ (Scaffold-Hopping) durch topologische Pharmakophorsuche: ein Beitrag zum virtuellen Screening

Angewandte Chemie, 1999-10, Vol.111 (19), p.3068-3070

1999

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Discovery of Ro 48-5695: A potent mixed endothelin receptor antagonist optimized from bosentan

Bioorganic & medicinal chemistry letters, 1997-09, Vol.7 (17), p.2223-2228

1997

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Ro 42-5892 Is a Potent Orally Active Renin Inhibitor in Primates

Hypertension (Dallas, Tex. 1979), 1991-07, Vol.18 (1), p.22-31

1991

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Evolutionäres De-novo-Design bioaktiver Moleküle: ein Ansatz zum virtuellen Screening

Angewandte Chemie, 2000-11, Vol.112 (22), p.4305-4309

2000

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In vitro characterisation of Ro 46-8443, the first non-peptide antagonist selective for the endothelin ET B receptor

FEBS letters, 1996-03, Vol.383 (1), p.37-41

1996

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Grundgerüstwechsel”︁ (Scaffold‐Hopping) durch topologische Pharmakophorsuche: ein Beitrag zum virtuellen Screening

Angewandte Chemie, 1999-10, Vol.111 (19), p.3068-3070

1999

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In vitro characterisation of Ro 46‐8443, the first non‐peptide antagonist selective for the endothelin ETB receptor

FEBS letters, 1996-03, Vol.383 (1-2), p.37-41

1996

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Evolutionäres De‐novo‐Design bioaktiver Moleküle: ein Ansatz zum virtuellen Screening

Angewandte Chemie, 2000-11, Vol.112 (22), p.4305-4309

2000

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Novel and Potent NPY5 Receptor Antagonists Derived from Virtual Screening and Iterative Parallel Chemistry Design

ChemInform, 2005-07, Vol.36 (29), p.no-no

2005

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"Scaffold-Hopping" by Topological Pharmacophore Search: A Contribution to Virtual Screening

Development of a Virtual Screening Method for Identification of “Frequent Hitters” in Compound Libraries

Challenges and Rewards in Medicinal Chemistry Targeting Cardiovascular and Metabolic Diseases

Stepwise Design of γ‑Secretase Modulators with an Advanced Profile by Judicious Coordinated Structural Replacements and an Unconventional Phenyl Ring Bioisostere

A Real-World Perspective on Molecular Design

Discovery of RO7185876, a Highly Potent γ-Secretase Modulator (GSM) as a Potential Treatment for Alzheimer’s Disease

Design and synthesis of selective, dual fatty acid binding protein 4 and 5 inhibitors

A Real-World Perspective on Molecular Design: Miniperspective

Novel and potent NPY5 receptor antagonists derived from virtual screening and iterative parallel chemistry design

Benzodioxoles: Novel Cannabinoid-1 Receptor Inverse Agonists for the Treatment of Obesity

Virtual Screening for Bioactive Molecules by Evolutionary De Novo Design

Ro 61-1790, a new hydrosoluble endothelin antagonist: general pharmacology and effects on experimental cerebral vasospasm

Channels and transporters. Mini-symposium of the Division of Medicinal Chemistry (DMC) of the Swiss Chemical Society (SCS) at the Department of Chemistry, University of Basel, May 27, 2010

Isomeric thiazole derivatives as ligands for the neuropeptide Y5 receptor

Establishment of robust functional assays for the characterization of neuropeptide Y (NPY) receptors: identification of 3-(5-benzoyl-thiazol-2-ylamino)-benzonitrile as selective NPY type 5 receptor antagonist

Aminothiazole Derivatives as Neuropeptide Y5 Receptor Ligands: Finding the Balance between Affinity and Physicochemical Properties

Grundgerüstwechsel"︁ (Scaffold-Hopping) durch topologische Pharmakophorsuche: ein Beitrag zum virtuellen Screening

Discovery of Ro 48-5695: A potent mixed endothelin receptor antagonist optimized from bosentan

Ro 42-5892 Is a Potent Orally Active Renin Inhibitor in Primates

Evolutionäres De-novo-Design bioaktiver Moleküle: ein Ansatz zum virtuellen Screening

In vitro characterisation of Ro 46-8443, the first non-peptide antagonist selective for the endothelin ET B receptor

Grundgerüstwechsel”︁ (Scaffold‐Hopping) durch topologische Pharmakophorsuche: ein Beitrag zum virtuellen Screening

In vitro characterisation of Ro 46‐8443, the first non‐peptide antagonist selective for the endothelin ETB receptor

Evolutionäres De‐novo‐Design bioaktiver Moleküle: ein Ansatz zum virtuellen Screening

Novel and Potent NPY5 Receptor Antagonists Derived from Virtual Screening and Iterative Parallel Chemistry Design

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