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Phenobarbital Meets Phosphorylation of Nuclear Receptors

Drug metabolism and disposition, 2017-05, Vol.45 (5), p.532-539

Negishi, Masahiko

2017

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Phosphorylated nuclear receptors as drug-targets

Drug metabolism and pharmacokinetics, 2019-01, Vol.34 (1), p.S2-S2

Negishi, Masahiko

2019

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Nuclear receptor phosphorylation in xenobiotic signal transduction

The Journal of biological chemistry, 2020-11, Vol.295 (45), p.15210-15225

2020

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Statin-activated nuclear receptor PXR promotes SGK2 dephosphorylation by scaffolding PP2C to induce hepatic gluconeogenesis

Scientific reports, 2015-09, Vol.5 (1), p.14076, Article 14076

2015

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Phenobarbital indirectly activates the constitutive active androstane receptor (CAR) by inhibition of epidermal growth factor receptor signaling

Science signaling, 2013-05, Vol.6 (274), p.ra31

2013

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CAR and PXR: The xenobiotic-sensing receptors

Steroids, 2007-03, Vol.72 (3), p.231-246

2007

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Regulation of gene expression by CAR: an update

Archives of toxicology, 2015-07, Vol.89 (7), p.1045-1055

2015

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Phosphorylation of nuclear receptors: Novelty and therapeutic implications

Pharmacology & therapeutics (Oxford), 2023-08, Vol.248, p.108477-108477, Article 108477

2023

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Glucose elicits serine/threonine kinase VRK1 to phosphorylate nuclear pregnane X receptor as a novel hepatic gluconeogenic signal

Cellular signalling, 2017-12, Vol.40, p.200-209

2017

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Serum- and glucocorticoid-regulated kinase 2 determines drug-activated pregnane X receptor to induce gluconeogenesis in human liver cells

The Journal of pharmacology and experimental therapeutics, 2014-01, Vol.348 (1), p.131-140

2014

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Nuclear Receptor CAR Suppresses GADD45B-p38 MAPK Signaling to Promote Phenobarbital-induced Proliferation in Mouse Liver

Molecular cancer research, 2018-08, Vol.16 (8), p.1309-1318

2018

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Nuclear Pregnane X Receptor Cross-talk with FoxA2 to Mediate Drug-induced Regulation of Lipid Metabolism in Fasting Mouse Liver

The Journal of biological chemistry, 2007-03, Vol.282 (13), p.9768-9776

2007

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Ligand induced dissociation of the AR homodimer precedes AR monomer translocation to the nucleus

Scientific reports, 2019-11, Vol.9 (1), p.16734-12, Article 16734

2019

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Phosphorylated Nuclear Receptor CAR Forms a Homodimer To Repress Its Constitutive Activity for Ligand Activation

Molecular and cellular biology, 2017-05, Vol.37 (10)

2017

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The Roles of Nuclear Receptors CAR and PXR in Hepatic Energy Metabolism

DRUG METABOLISM AND PHARMACOKINETICS, 2008-01, Vol.23 (1), p.8-13

2008

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CAR requires Gadd45β to promote phenobarbital-induced mouse liver tumors in early stage

Frontiers in oncology, 2023-09, Vol.13, p.1217847-1217847

2023

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Nuclear receptor CAR-ERα signaling regulates the estrogen sulfotransferase gene in the liver

Scientific reports, 2020-03, Vol.10 (1), p.5001, Article 5001

2020

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A phosphorylation-deficient mutant of retinoid X receptor α at Thr 167 alters fasting response and energy metabolism in mice

Laboratory investigation, 2019-10, Vol.99 (10), p.1470-1483

2019

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Nuclear Receptors CAR and PXR Cross Talk with FOXO1 To Regulate Genes That Encode Drug-Metabolizing and Gluconeogenic Enzymes

Molecular and Cellular Biology, 2004-09, Vol.24 (18), p.7931-7940

2004

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Coordinated regulation of nuclear receptor CAR by CCRP/DNAJC7, HSP70 and the ubiquitin-proteasome system

PloS one, 2014-05, Vol.9 (5), p.e96092

2014

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Serine 216 phosphorylation of estrogen receptor α in neutrophils: migration and infiltration into the mouse uterus

PloS one, 2013-12, Vol.8 (12), p.e84462

2013

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Regulation of cytochrome P450 (CYP) genes by nuclear receptors

Biochemical journal, 2000-04, Vol.347 (Pt 2), p.321-337

2000

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Estrogen Sulfotransferase (SULT1E1): Its Molecular Regulation, Polymorphisms, and Clinical Perspectives

Journal of personalized medicine, 2021-03, Vol.11 (3), p.194

2021

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The roles of co-chaperone CCRP/DNAJC7 in Cyp2b10 gene activation and steatosis development in mouse livers

PloS one, 2014-12, Vol.9 (12), p.e115663-e115663

2014

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Dephosphorylation of Threonine 38 Is Required for Nuclear Translocation and Activation of Human Xenobiotic Receptor CAR (NR1I3)

The Journal of biological chemistry, 2009-12, Vol.284 (50), p.34785-34792

2009

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Phenobarbital Meets Phosphorylation of Nuclear Receptors

Phosphorylated nuclear receptors as drug-targets

Nuclear receptor phosphorylation in xenobiotic signal transduction

Statin-activated nuclear receptor PXR promotes SGK2 dephosphorylation by scaffolding PP2C to induce hepatic gluconeogenesis

Phenobarbital indirectly activates the constitutive active androstane receptor (CAR) by inhibition of epidermal growth factor receptor signaling

CAR and PXR: The xenobiotic-sensing receptors

Regulation of gene expression by CAR: an update

Phosphorylation of nuclear receptors: Novelty and therapeutic implications

Glucose elicits serine/threonine kinase VRK1 to phosphorylate nuclear pregnane X receptor as a novel hepatic gluconeogenic signal

Serum- and glucocorticoid-regulated kinase 2 determines drug-activated pregnane X receptor to induce gluconeogenesis in human liver cells

Nuclear Receptor CAR Suppresses GADD45B-p38 MAPK Signaling to Promote Phenobarbital-induced Proliferation in Mouse Liver

Nuclear Pregnane X Receptor Cross-talk with FoxA2 to Mediate Drug-induced Regulation of Lipid Metabolism in Fasting Mouse Liver

Ligand induced dissociation of the AR homodimer precedes AR monomer translocation to the nucleus

Phosphorylated Nuclear Receptor CAR Forms a Homodimer To Repress Its Constitutive Activity for Ligand Activation

The Roles of Nuclear Receptors CAR and PXR in Hepatic Energy Metabolism

CAR requires Gadd45β to promote phenobarbital-induced mouse liver tumors in early stage

Nuclear receptor CAR-ERα signaling regulates the estrogen sulfotransferase gene in the liver

A phosphorylation-deficient mutant of retinoid X receptor α at Thr 167 alters fasting response and energy metabolism in mice

Nuclear Receptors CAR and PXR Cross Talk with FOXO1 To Regulate Genes That Encode Drug-Metabolizing and Gluconeogenic Enzymes

Coordinated regulation of nuclear receptor CAR by CCRP/DNAJC7, HSP70 and the ubiquitin-proteasome system

Serine 216 phosphorylation of estrogen receptor α in neutrophils: migration and infiltration into the mouse uterus

Regulation of cytochrome P450 (CYP) genes by nuclear receptors

Estrogen Sulfotransferase (SULT1E1): Its Molecular Regulation, Polymorphisms, and Clinical Perspectives

The roles of co-chaperone CCRP/DNAJC7 in Cyp2b10 gene activation and steatosis development in mouse livers

Dephosphorylation of Threonine 38 Is Required for Nuclear Translocation and Activation of Human Xenobiotic Receptor CAR (NR1I3)

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