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The mitochondrial type IB topoisomerase drives mitochondrial translation and carcinogenesis

Nature communications, 2019-01, Vol.10 (1), p.83-13, Article 83

2019

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Stabilization of wild-type p53 by hypoxia-inducible factor 1α

Nature (London), 1998-03, Vol.392 (6674), p.405-408

1998

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The Hsp90 inhibitor geldanamycin selectively sensitizes Bcr-Abl-expressing leukemia cells to cytotoxic chemotherapy

Leukemia, 2001-10, Vol.15 (10), p.1537-1543

2001

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The benzoquinone ansamycin 17-allylamino-17-demethoxygeldanamycin binds to HSP90 and shares important biologic activities with geldanamycin

Cancer chemotherapy and pharmacology, 1998, Vol.42 (4), p.273-279

1998

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Taxol-induced apoptosis and phosphorylation of Bcl-2 protein involves c-Raf-1 and represents a novel c-Raf-1 signal transduction pathway

Cancer research (Chicago, Ill.), 1996-04, Vol.56 (8), p.1851-1854

1996

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KF25706, a novel oxime derivative of radicicol, exhibits in vivo antitumor activity via selective depletion of Hsp90 binding signaling molecules

Cancer research (Chicago, Ill.), 1999-06, Vol.59 (12), p.2931-2938

1999

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Characterization of Oligonucleotide Transport into Living Cells

Proceedings of the National Academy of Sciences - PNAS, 1989-05, Vol.86 (10), p.3474-3478

1989

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Hsp90 Regulates a von Hippel Lindau-independent Hypoxia-inducible Factor-1α-degradative Pathway

The Journal of biological chemistry, 2002-08, Vol.277 (33), p.29936-29944

2002

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Stability, Clearance, and Disposition of Intraventricularly Administered Oligodeoxynucleotides: Implications for Therapeutic Application within the Central Nervous System

Proceedings of the National Academy of Sciences - PNAS, 1993-05, Vol.90 (10), p.4665-4669

1993

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Destabilization of Raf-1 by geldanamycin leads to disruption of the Raf-1-MEK-mitogen-activated protein kinase signalling pathway

Molecular and Cellular Biology, 1996-10, Vol.16 (10), p.5839-5845

1996

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Tumor-intrinsic and tumor-extrinsic factors impacting hsp90- targeted therapy

Current molecular medicine, 2012-11, Vol.12 (9), p.1125-1141

2012

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The Heat Shock Protein 90 Antagonist Novobiocin Interacts with a Previously Unrecognized ATP-binding Domain in the Carboxyl Terminus of the Chaperone

The Journal of biological chemistry, 2000-11, Vol.275 (47), p.37181-37186

2000

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Benzoquinonoid ansamycins possess selective tumoricidal activity unrelated to src kinase inhibition

Cancer research (Baltimore), 1992-04, Vol.52 (7), p.1721-1728

1992

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Regulation of BRCA1 by protein degradation

Oncogene, 1999-11, Vol.18 (47), p.6460-6468

1999

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Stereospecific antitumor activity of radicicol oxime derivatives

Cancer chemotherapy and pharmacology, 2001-12, Vol.48 (6), p.435-445

2001

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A c-myc antisense oligodeoxynucleotide inhibits entry into S phase but not progress from G0 to G1

Nature (London), 1987-07, Vol.328 (6129), p.445-449

1987

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In vivo degradation of N-myc in neuroblastoma cells is mediated by the 26S proteasome

Oncogene, 1998-03, Vol.16 (9), p.1131-1139

1998

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Tumour-specific inhibition of lymphoma growth by an antisense oligodeoxynucleotide

The Lancet (British edition), 1990-04, Vol.335 (8693), p.808-811

1990

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Transferrin Receptor Induction in Mitogen-Stimulated Human T Lymphocytes is Required for DNA Synthesis and Cell Division and is Regulated by Interleukin 2

Proceedings of the National Academy of Sciences - PNAS, 1983-06, Vol.80 (11), p.3494-3498

1983

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The Amino-terminal Domain of Heat Shock Protein 90 (hsp90) That Binds Geldanamycin Is an ATP/ADP Switch Domain That Regulates hsp90 Conformation

The Journal of biological chemistry, 1997-09, Vol.272 (38), p.23843-23850

1997

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Antibiotic Radicicol Binds to the N-Terminal Domain of Hsp90 and Shares Important Biologic Activities with Geldanamycin

Cell stress & chaperones, 1998-06, Vol.3 (2), p.100-108

1998

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Comparative inhibition of rabbit globin mRNA translation by modified antisense oligodeoxynucleotides

Nucleic acids research, 1989-06, Vol.17 (11), p.4255-4273

1989

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Characterization of an Interleukin-6-Mediated Autocrine Growth Loop in the Human Multiple Myeloma Cell Line, U266

Blood, 1991-02, Vol.77 (3), p.587-593

1991

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aHIF: the Missing Link Between HIF-1 and VHL?

JNCI : Journal of the National Cancer Institute, 1999-01, Vol.91 (2), p.106-107

Neckers, L M

1999

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Expression of the insulin-like growth factor I receptor and urokinase plasminogen activator in breast Cancer is associated with poor survival: Potential for intervention with 17-allylamino geldanamycin

Cancer research (Chicago, Ill.), 2004, Vol.64 (1), p.286-291

2004

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The mitochondrial type IB topoisomerase drives mitochondrial translation and carcinogenesis

Stabilization of wild-type p53 by hypoxia-inducible factor 1α

The Hsp90 inhibitor geldanamycin selectively sensitizes Bcr-Abl-expressing leukemia cells to cytotoxic chemotherapy

The benzoquinone ansamycin 17-allylamino-17-demethoxygeldanamycin binds to HSP90 and shares important biologic activities with geldanamycin

Taxol-induced apoptosis and phosphorylation of Bcl-2 protein involves c-Raf-1 and represents a novel c-Raf-1 signal transduction pathway

KF25706, a novel oxime derivative of radicicol, exhibits in vivo antitumor activity via selective depletion of Hsp90 binding signaling molecules

Characterization of Oligonucleotide Transport into Living Cells

Hsp90 Regulates a von Hippel Lindau-independent Hypoxia-inducible Factor-1α-degradative Pathway

Stability, Clearance, and Disposition of Intraventricularly Administered Oligodeoxynucleotides: Implications for Therapeutic Application within the Central Nervous System

Destabilization of Raf-1 by geldanamycin leads to disruption of the Raf-1-MEK-mitogen-activated protein kinase signalling pathway

Tumor-intrinsic and tumor-extrinsic factors impacting hsp90- targeted therapy

The Heat Shock Protein 90 Antagonist Novobiocin Interacts with a Previously Unrecognized ATP-binding Domain in the Carboxyl Terminus of the Chaperone

Benzoquinonoid ansamycins possess selective tumoricidal activity unrelated to src kinase inhibition

Regulation of BRCA1 by protein degradation

Stereospecific antitumor activity of radicicol oxime derivatives

A c-myc antisense oligodeoxynucleotide inhibits entry into S phase but not progress from G0 to G1

In vivo degradation of N-myc in neuroblastoma cells is mediated by the 26S proteasome

Tumour-specific inhibition of lymphoma growth by an antisense oligodeoxynucleotide

Transferrin Receptor Induction in Mitogen-Stimulated Human T Lymphocytes is Required for DNA Synthesis and Cell Division and is Regulated by Interleukin 2

The Amino-terminal Domain of Heat Shock Protein 90 (hsp90) That Binds Geldanamycin Is an ATP/ADP Switch Domain That Regulates hsp90 Conformation

Antibiotic Radicicol Binds to the N-Terminal Domain of Hsp90 and Shares Important Biologic Activities with Geldanamycin

Comparative inhibition of rabbit globin mRNA translation by modified antisense oligodeoxynucleotides

Characterization of an Interleukin-6-Mediated Autocrine Growth Loop in the Human Multiple Myeloma Cell Line, U266

aHIF: the Missing Link Between HIF-1 and VHL?

Expression of the insulin-like growth factor I receptor and urokinase plasminogen activator in breast Cancer is associated with poor survival: Potential for intervention with 17-allylamino geldanamycin

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