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The Structure of Human 5-Lipoxygenase

Science (American Association for the Advancement of Science), 2011-01, Vol.331 (6014), p.217-219

2011

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Conversion of human 5‐lipoxygenase to a 15‐lipoxygenase by a point mutation to mimic phosphorylation at Serine‐663

The FASEB journal, 2012-08, Vol.26 (8), p.3222-3229

2012

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Structural basis for ligand and heparin binding to neuropilin B domains

Proceedings of the National Academy of Sciences - PNAS, 2007-04, Vol.104 (15), p.6152-6157

2007

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Structural and mechanistic insights into 5-lipoxygenase inhibition by natural products

Nature chemical biology, 2020-07, Vol.16 (7), p.783

2020

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The 1.85 Å Structure of an 8R-Lipoxygenase Suggests a General Model for Lipoxygenase Product Specificity

Biochemistry (Easton), 2009-08, Vol.48 (33), p.7906-7915

2009

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The Three-Dimensional Structure of the Biotin Carboxylase-Biotin Carboxyl Carrier Protein Complex of E. coli Acetyl-CoA Carboxylase

Structure (London), 2013-04, Vol.21 (4), p.650-657

2013

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The Structure of Human 15-Lipoxygenase-2 with a Substrate Mimic

The Journal of biological chemistry, 2014-03, Vol.289 (12), p.8562-8569

2014

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C-terminal modification of the insulin B:11–23 peptide creates superagonists in mouse and human type 1 diabetes

Proceedings of the National Academy of Sciences - PNAS, 2018-01, Vol.115 (1), p.162-167

2018

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Helical remodeling augments 5-lipoxygenase activity in the synthesis of proinflammatory mediators

The Journal of biological chemistry, 2022-09, Vol.298 (9), p.102282-102282, Article 102282

2022

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Crystal structure of a lipoxygenase in complex with substrate: the arachidonic acid-binding site of 8R-lipoxygenase

The Journal of biological chemistry, 2014-11, Vol.289 (46), p.31905-31913

2014

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Kinetic and structural investigations of novel inhibitors of human epithelial 15-lipoxygenase-2

Bioorganic & medicinal chemistry, 2021-09, Vol.46, p.116349-116349, Article 116349

2021

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Expression of an 8R-Lipoxygenase From the Coral Plexaura homomalla

Methods in enzymology, 2018, Vol.605, p.33-49

2018

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Optimization and Mechanistic Characterization of Pyridopyrimidine Inhibitors of Bacterial Biotin Carboxylase

Journal of medicinal chemistry, 2019-08, Vol.62 (16), p.7489-7505

2019

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An ensemble of lipoxygenase structures reveals novel conformations of the Fe coordination sphere

Protein science, 2019-05, Vol.28 (5), p.920-927

2019

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Structural Basis of the Enhanced Pollutant-Degrading Capabilities of an Engineered Biphenyl Dioxygenase

Journal of bacteriology, 2016-05, Vol.198 (10), p.1499-1512

2016

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Crystal Structure of Carboxyltransferase from Staphylococcus aureus Bound to the Antibacterial Agent Moiramide B

Biochemistry (Easton), 2016-08, Vol.55 (33), p.4666-4674

2016

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Identification and analysis of a bottleneck in PCB biodegradation

Nature structural & molecular biology, 2002-12, Vol.9 (12), p.934-939

2002

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Structural Analysis of Substrate, Reaction Intermediate, and Product Binding in Haemophilus influenzae Biotin Carboxylase

Biochemistry (Easton), 2015-06, Vol.54 (24), p.3860-3870

2015

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Covalent Small Molecule Inhibitors of Ca2+-Bound S100B

Biochemistry (Easton), 2014-10, Vol.53 (42), p.6628-6640

2014

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Covalent small molecule inhibitors of Ca(2+)-bound S100B

Biochemistry (Easton), 2014-10, Vol.53 (42), p.6628-6640

2014

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Structural insights into the binding of the human receptor for advanced glycation end products (RAGE) by S100B, as revealed by an S100B-RAGE-derived peptide complex

Acta crystallographica. Section D, Biological crystallography., 2015-05, Vol.71 (5), p.1176-1183

2015

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Directed Evolution of a Ring-cleaving Dioxygenase for Polychlorinated Biphenyl Degradation

The Journal of biological chemistry, 2005-12, Vol.280 (51), p.42307-42314

2005

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Mechanistic Implications of the Unique Structural Features and Dimerization of the Cytoplasmic Domain of the Pseudomonas Sigma Regulator, PupR

Biochemistry (Easton), 2015-09, Vol.54 (38), p.5867-5877

2015

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Small Molecule Inhibitors of Ca2+-S100B Reveal Two Protein Conformations

Journal of medicinal chemistry, 2016-01, Vol.59 (2), p.592-608

2016

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Small Molecule Inhibitors of Ca(2+)-S100B Reveal Two Protein Conformations

Journal of medicinal chemistry, 2016-01, Vol.59 (2), p.592-608

2016

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The Structure of Human 5-Lipoxygenase

Conversion of human 5‐lipoxygenase to a 15‐lipoxygenase by a point mutation to mimic phosphorylation at Serine‐663

Structural basis for ligand and heparin binding to neuropilin B domains

Structural and mechanistic insights into 5-lipoxygenase inhibition by natural products

The 1.85 Å Structure of an 8R-Lipoxygenase Suggests a General Model for Lipoxygenase Product Specificity

The Three-Dimensional Structure of the Biotin Carboxylase-Biotin Carboxyl Carrier Protein Complex of E. coli Acetyl-CoA Carboxylase

The Structure of Human 15-Lipoxygenase-2 with a Substrate Mimic

C-terminal modification of the insulin B:11–23 peptide creates superagonists in mouse and human type 1 diabetes

Helical remodeling augments 5-lipoxygenase activity in the synthesis of proinflammatory mediators

Crystal structure of a lipoxygenase in complex with substrate: the arachidonic acid-binding site of 8R-lipoxygenase

Kinetic and structural investigations of novel inhibitors of human epithelial 15-lipoxygenase-2

Expression of an 8R-Lipoxygenase From the Coral Plexaura homomalla

Optimization and Mechanistic Characterization of Pyridopyrimidine Inhibitors of Bacterial Biotin Carboxylase

An ensemble of lipoxygenase structures reveals novel conformations of the Fe coordination sphere

Structural Basis of the Enhanced Pollutant-Degrading Capabilities of an Engineered Biphenyl Dioxygenase

Crystal Structure of Carboxyltransferase from Staphylococcus aureus Bound to the Antibacterial Agent Moiramide B

Identification and analysis of a bottleneck in PCB biodegradation

Structural Analysis of Substrate, Reaction Intermediate, and Product Binding in Haemophilus influenzae Biotin Carboxylase

Covalent Small Molecule Inhibitors of Ca2+-Bound S100B

Covalent small molecule inhibitors of Ca(2+)-bound S100B

Structural insights into the binding of the human receptor for advanced glycation end products (RAGE) by S100B, as revealed by an S100B-RAGE-derived peptide complex

Directed Evolution of a Ring-cleaving Dioxygenase for Polychlorinated Biphenyl Degradation

Mechanistic Implications of the Unique Structural Features and Dimerization of the Cytoplasmic Domain of the Pseudomonas Sigma Regulator, PupR

Small Molecule Inhibitors of Ca2+-S100B Reveal Two Protein Conformations

Small Molecule Inhibitors of Ca(2+)-S100B Reveal Two Protein Conformations

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