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NAAG peptidase inhibitors and their potential for diagnosis and therapy

Nature reviews. Drug discovery, 2005-12, Vol.4 (12), p.1015-1026

2005

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N-acetylaspartylglutamate : The most abundant peptide neurotransmitter in the mammalian central nervous system

Journal of neurochemistry, 2000-08, Vol.75 (2), p.443-452

2000

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The neurotransmitter N-acetylaspartylglutamate in models of pain, ALS, diabetic neuropathy, CNS injury and schizophrenia

Trends in pharmacological sciences (Regular ed.), 2005-09, Vol.26 (9), p.477-484

2005

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Synthesis of Urea-Based Inhibitors as Active Site Probes of Glutamate Carboxypeptidase II: Efficacy as Analgesic Agents

Journal of medicinal chemistry, 2004-03, Vol.47 (7), p.1729-1738

2004

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Design of Remarkably Simple, Yet Potent Urea-Based Inhibitors of Glutamate Carboxypeptidase II (NAALADase)

Journal of medicinal chemistry, 2001-02, Vol.44 (3), p.298-301

2001

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NAAG peptidase inhibitor increases dialysate NAAG and reduces glutamate, aspartate and GABA levels in the dorsal hippocampus following fluid percussion injury in the rat

Journal of neurochemistry, 2006-05, Vol.97 (4), p.1015-1025

2006

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NAAG peptidase inhibition reduces locomotor activity and some stereotypes in the PCP model of schizophrenia via group II mGluR

Journal of neurochemistry, 2004-05, Vol.89 (4), p.876-885

2004

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Antinociceptive effects of N-acetylaspartylglutamate (NAAG) peptidase inhibitors ZJ-11, ZJ-17 and ZJ-43 in the rat formalin test and in the rat neuropathic pain model

The European journal of neuroscience, 2004-07, Vol.20 (2), p.483-494

2004

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N‐Acetylaspartylglutamate Selectively Activates mGluR3 Receptors in Transfected Cells

Journal of neurochemistry, 1997-07, Vol.69 (1), p.174-181

1997

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NAAG peptidase inhibitor reduces acute neuronal degeneration and astrocyte damage following lateral fluid percussion TBI in rats

Journal of neurotrauma, 2005-02, Vol.22 (2), p.266-276

2005

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Differential negative coupling of type 3 metabotropic glutamate receptor to cyclic GMP levels in neurons and astrocytes

Journal of neurochemistry, 2006-02, Vol.96 (4), p.1071-1077

2006

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The cloning and characterization of a second brain enzyme with NAAG peptidase activity

Journal of neurochemistry, 2004-05, Vol.89 (3), p.627-635

2004

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Biosynthesis of NAAG by an enzyme‐mediated process in rat central nervous system neurons and glia

Journal of neurochemistry, 2004-08, Vol.90 (4), p.989-997

2004

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NAAG inhibits KCl-induced [(3)H]-GABA release via mGluR3, cAMP, PKA and L-type calcium conductance

The European journal of neuroscience, 2001-01, Vol.13 (2), p.340-346

2001

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GABA-induced neurite outgrowth of cerebellar granule cells is mediated by GABA(A) receptor activation, calcium influx and CaMKII and erk1/2 pathways

Journal of neurochemistry, 2003-03, Vol.84 (6), p.1411-1420

2003

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Deletion of the glutamate carboxypeptidase II gene in mice reveals a second enzyme activity that hydrolyzes N‐acetylaspartylglutamate

Journal of neurochemistry, 2002-10, Vol.83 (1), p.20-29

2002

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N-acetylaspartylglutamate activates cyclic AMP-coupled metabotropic glutamate receptors in cerebellar astrocytes

Glia, 1998-10, Vol.24 (2), p.172-179

1998

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Dual Function Glutamate-Related Ligands: Discovery of a Novel, Potent Inhibitor of Glutamate Carboxypeptidase II Possessing mGluR3 Agonist Activity

Journal of medicinal chemistry, 2000-03, Vol.43 (5), p.772-774

2000

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Molecular Modeling of the Interactions of Glutamate Carboxypeptidase II with Its Potent NAAG-Based Inhibitors

Journal of medicinal chemistry, 2002-09, Vol.45 (19), p.4140-4152

2002

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beta-NAAG rescues LTP from blockade by NAAG in rat dentate gyrus via the type 3 metabotropic glutamate receptor

Journal of neurophysiology, 2001-03, Vol.85 (3), p.1097-1106

2001

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Molecular Cloning of a Peptidase Against N‐Acetylaspartylglutamate from a Rat Hippocampal cDNA Library

Journal of neurochemistry, 1997-12, Vol.69 (6), p.2270-2277

1997

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Immunohistochemical localization of N-acetylaspartate in rat brain

Neuroreport, 1991-03, Vol.2 (3), p.131-134

1991

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The Regional Distribution of N‐Acetylaspartylglutamate (NAAG) and Peptidase Activity Against NAAG in the Rat Nervous System

Journal of neurochemistry, 1994-01, Vol.62 (1), p.275-281

1994

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N‐Acetylaspartylglutamate Inhibits Forskolin‐Stimulated Cyclic AMP Levels via a Metabotropic Glutamate Receptor in Cultured Cerebellar Granule Cells

Journal of neurochemistry, 1993-09, Vol.61 (3), p.943-948

1993

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Enhanced carbodiimide fixation for immunohistochemistry: application to the comparative distributions of N-acetylaspartylglutamate and N- acetylaspartate immunoreactivities in rat brain

The journal of histochemistry and cytochemistry, 1993-04, Vol.41 (4), p.559-570

1993

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NAAG peptidase inhibitors and their potential for diagnosis and therapy

N-acetylaspartylglutamate : The most abundant peptide neurotransmitter in the mammalian central nervous system

The neurotransmitter N-acetylaspartylglutamate in models of pain, ALS, diabetic neuropathy, CNS injury and schizophrenia

Synthesis of Urea-Based Inhibitors as Active Site Probes of Glutamate Carboxypeptidase II: Efficacy as Analgesic Agents

Design of Remarkably Simple, Yet Potent Urea-Based Inhibitors of Glutamate Carboxypeptidase II (NAALADase)

NAAG peptidase inhibitor increases dialysate NAAG and reduces glutamate, aspartate and GABA levels in the dorsal hippocampus following fluid percussion injury in the rat

NAAG peptidase inhibition reduces locomotor activity and some stereotypes in the PCP model of schizophrenia via group II mGluR

Antinociceptive effects of N-acetylaspartylglutamate (NAAG) peptidase inhibitors ZJ-11, ZJ-17 and ZJ-43 in the rat formalin test and in the rat neuropathic pain model

N‐Acetylaspartylglutamate Selectively Activates mGluR3 Receptors in Transfected Cells

NAAG peptidase inhibitor reduces acute neuronal degeneration and astrocyte damage following lateral fluid percussion TBI in rats

Differential negative coupling of type 3 metabotropic glutamate receptor to cyclic GMP levels in neurons and astrocytes

The cloning and characterization of a second brain enzyme with NAAG peptidase activity

Biosynthesis of NAAG by an enzyme‐mediated process in rat central nervous system neurons and glia

NAAG inhibits KCl-induced [(3)H]-GABA release via mGluR3, cAMP, PKA and L-type calcium conductance

GABA-induced neurite outgrowth of cerebellar granule cells is mediated by GABA(A) receptor activation, calcium influx and CaMKII and erk1/2 pathways

Deletion of the glutamate carboxypeptidase II gene in mice reveals a second enzyme activity that hydrolyzes N‐acetylaspartylglutamate

N-acetylaspartylglutamate activates cyclic AMP-coupled metabotropic glutamate receptors in cerebellar astrocytes

Dual Function Glutamate-Related Ligands: Discovery of a Novel, Potent Inhibitor of Glutamate Carboxypeptidase II Possessing mGluR3 Agonist Activity

Molecular Modeling of the Interactions of Glutamate Carboxypeptidase II with Its Potent NAAG-Based Inhibitors

beta-NAAG rescues LTP from blockade by NAAG in rat dentate gyrus via the type 3 metabotropic glutamate receptor

Molecular Cloning of a Peptidase Against N‐Acetylaspartylglutamate from a Rat Hippocampal cDNA Library

Immunohistochemical localization of N-acetylaspartate in rat brain

The Regional Distribution of N‐Acetylaspartylglutamate (NAAG) and Peptidase Activity Against NAAG in the Rat Nervous System

N‐Acetylaspartylglutamate Inhibits Forskolin‐Stimulated Cyclic AMP Levels via a Metabotropic Glutamate Receptor in Cultured Cerebellar Granule Cells

Enhanced carbodiimide fixation for immunohistochemistry: application to the comparative distributions of N-acetylaspartylglutamate and N- acetylaspartate immunoreactivities in rat brain

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