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Magnitude of Therapeutic STING Activation Determines CD8+ T Cell-Mediated Anti-tumor Immunity

Cell reports (Cambridge), 2018-12, Vol.25 (11), p.3074-3085.e5

2018

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Discovery of Selective 4‑Amino-pyridopyrimidine Inhibitors of MAP4K4 Using Fragment-Based Lead Identification and Optimization

Journal of medicinal chemistry, 2014-04, Vol.57 (8), p.3484-3493

2014

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NK cells mediate clearance of CD8 + T cell-resistant tumors in response to STING agonists

Science immunology, 2020-03, Vol.5 (45)

2020

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Synergy of a STING agonist and an IL-2 superkine in cancer immunotherapy against MHC I-deficient and MHC I + tumors

Proceedings of the National Academy of Sciences - PNAS, 2022-05, Vol.119 (22), p.e2200568119-e2200568119

2022

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Combining STING-based neoantigen-targeted vaccine with checkpoint modulators enhances antitumor immunity in murine pancreatic cancer

JCI insight, 2018-10, Vol.3 (20)

2018

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Discovery of 2‑{3-[2-(1-Isopropyl-3-methyl‑1H‑1,2–4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2‑d][1,4]oxazepin-9-yl]‑1H‑pyrazol-1-yl}-2-methylpropanamide (GDC-0032): A β‑Sparing Phosphoinositide 3‑Kinase Inhibitor with High Unbound Exposure and Robust in Vivo Antitumor Activity

Journal of medicinal chemistry, 2013-06, Vol.56 (11), p.4597-4610

2013

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Discovery of Clinical Development Candidate GDC-0084, a Brain Penetrant Inhibitor of PI3K and mTOR

ACS medicinal chemistry letters, 2016-04, Vol.7 (4), p.351-356

2016

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Chemically Diverse Group I p21-Activated Kinase (PAK) Inhibitors Impart Acute Cardiovascular Toxicity with a Narrow Therapeutic Window

Journal of medicinal chemistry, 2016-06, Vol.59 (11), p.5520-5541

2016

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Magnitude of Therapeutic STING Activation Determines CD8+ T Cell-Mediated Anti-tumor Immunity

Cell reports (Cambridge), 2019-10, Vol.29 (3), p.785-789

2019

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Design of Selective PAK1 Inhibitor G‑5555: Improving Properties by Employing an Unorthodox Low‑pK a Polar Moiety

ACS medicinal chemistry letters, 2015-12, Vol.6 (12), p.1241-1246

2015

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Structure-Based Design of GNE-495, a Potent and Selective MAP4K4 Inhibitor with Efficacy in Retinal Angiogenesis

ACS medicinal chemistry letters, 2015-08, Vol.6 (8), p.913-918

2015

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Fragment-based identification and optimization of a class of potent pyrrolo[2,1-f][1,2,4]triazine MAP4K4 inhibitors

Bioorganic & medicinal chemistry letters, 2014-09, Vol.24 (18), p.4546-4552

2014

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anti-1,2-Diols via Ni-Catalyzed Reductive Coupling of Alkynes and α-Oxyaldehydes

Organic letters, 2005-07, Vol.7 (14), p.2937-2940

2005

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A Versatile Annulation Route to Primary-Amino-Substituted Naphthyridine Esters

Synlett, 2014-01, Vol.25 (1), p.89-92

2014

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Design of Selective PAK1 Inhibitor G-5555: Improving Properties by Employing an Unorthodox Low-pKa Polar Moiety

ACS medicinal chemistry letters, 2015-10, Vol.6 (12), p.1241-1246

2015

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Abstract 1202: Tumor cell intrinsic STING signaling demonstrates minimal contribution to the anti-tumor response elicited by the STING agonist ADU-S100 (MIW815)

Cancer research (Chicago, Ill.), 2019-07, Vol.79 (13_Supplement), p.1202-1202

2019

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Abstract 2633: Discovery of novel, highly selective inhibitors of PLK4 that demonstrate in vivo regressions in TRIM37 high xenografts

Cancer research (Chicago, Ill.), 2022-06, Vol.82 (12_Supplement), p.2633-2633

2022

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Abstract 2074: ORIC-533, a small molecule CD73 inhibitor with best-in-class properties, reversesimmunosuppression and has potential as an immunomodulatory therapy in patients with multiple myeloma

Cancer research (Chicago, Ill.), 2022-06, Vol.82 (12_Supplement), p.2074-2074

2022

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Fragment-based identification and optimization of a class of potent pyrrolo[2,1-f][1,2,4]triazine MAP4K4 inhibitors

Bioorganic & medicinal chemistry letters, 2014-09, Vol.24 (18)

2014

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ChemInform Abstract: A Versatile Annulation Route to Primary-Amino-Substituted Naphthyridine Esters

ChemInform, 2014-06, Vol.45 (24), p.no-no

2014

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Design of Selective PAK1 Inhibitor G-5555: Improving Properties by Employing an Unorthodox Low-p K a Polar Moiety

ACS medicinal chemistry letters, 2015-12, Vol.6 (12), p.1241-1246

2015

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Diastereoselective nickel -catalyzed reductive coupling of alkynes and aldehydes and application towards the B-type amphidinolides

Ndubaku, Chudi O

2006

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anti-1,2-Diols via Ni-Catalyzed Reductive Coupling of Alkynes and α-Oxyaldehydes

ChemInform, 2005-11, Vol.36 (44), p.no-no

2005

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Magnitude of Therapeutic STING Activation Determines CD8+ T Cell-Mediated Anti-tumor Immunity

Discovery of Selective 4‑Amino-pyridopyrimidine Inhibitors of MAP4K4 Using Fragment-Based Lead Identification and Optimization

NK cells mediate clearance of CD8 + T cell-resistant tumors in response to STING agonists

Synergy of a STING agonist and an IL-2 superkine in cancer immunotherapy against MHC I-deficient and MHC I + tumors

Combining STING-based neoantigen-targeted vaccine with checkpoint modulators enhances antitumor immunity in murine pancreatic cancer

Discovery of 2‑{3-[2-(1-Isopropyl-3-methyl‑1H‑1,2–4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2‑d][1,4]oxazepin-9-yl]‑1H‑pyrazol-1-yl}-2-methylpropanamide (GDC-0032): A β‑Sparing Phosphoinositide 3‑Kinase Inhibitor with High Unbound Exposure and Robust in Vivo Antitumor Activity

Discovery of a Potent and Selective BCL‑XL Inhibitor with in Vivo Activity

Discovery of Clinical Development Candidate GDC-0084, a Brain Penetrant Inhibitor of PI3K and mTOR

Chemically Diverse Group I p21-Activated Kinase (PAK) Inhibitors Impart Acute Cardiovascular Toxicity with a Narrow Therapeutic Window

Magnitude of Therapeutic STING Activation Determines CD8+ T Cell-Mediated Anti-tumor Immunity

Design of Selective PAK1 Inhibitor G‑5555: Improving Properties by Employing an Unorthodox Low‑pK a Polar Moiety

Structure-Based Design of GNE-495, a Potent and Selective MAP4K4 Inhibitor with Efficacy in Retinal Angiogenesis

Fragment-based identification and optimization of a class of potent pyrrolo[2,1-f][1,2,4]triazine MAP4K4 inhibitors

anti-1,2-Diols via Ni-Catalyzed Reductive Coupling of Alkynes and α-Oxyaldehydes

A Versatile Annulation Route to Primary-Amino-Substituted Naphthyridine Esters

Design of Selective PAK1 Inhibitor G-5555: Improving Properties by Employing an Unorthodox Low-pKa Polar Moiety

Abstract 1202: Tumor cell intrinsic STING signaling demonstrates minimal contribution to the anti-tumor response elicited by the STING agonist ADU-S100 (MIW815)

Abstract 2633: Discovery of novel, highly selective inhibitors of PLK4 that demonstrate in vivo regressions in TRIM37 high xenografts

Abstract 2074: ORIC-533, a small molecule CD73 inhibitor with best-in-class properties, reversesimmunosuppression and has potential as an immunomodulatory therapy in patients with multiple myeloma

Fragment-based identification and optimization of a class of potent pyrrolo[2,1-f][1,2,4]triazine MAP4K4 inhibitors

ChemInform Abstract: A Versatile Annulation Route to Primary-Amino-Substituted Naphthyridine Esters

Design of Selective PAK1 Inhibitor G-5555: Improving Properties by Employing an Unorthodox Low-p K a Polar Moiety

Discovery of a Potent and Selective BCL-X L Inhibitor with in Vivo Activity

Diastereoselective nickel -catalyzed reductive coupling of alkynes and aldehydes and application towards the B-type amphidinolides

anti-1,2-Diols via Ni-Catalyzed Reductive Coupling of Alkynes and α-Oxyaldehydes

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