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Isoform-selective targeting of PI3K: time to consider new opportunities?

Trends in pharmacological sciences (Regular ed.), 2023-09, Vol.44 (9), p.601-621

2023

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Revealing cytotoxic substructures in molecules using deep learning

Journal of computer-aided molecular design, 2020-07, Vol.34 (7), p.731-746

2020

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An Activatable Lanthanide Luminescent Probe for Time‐Gated Detection of Nitroreductase in Live Bacteria

Angewandte Chemie (International ed.), 2020-05, Vol.59 (22), p.8512-8516

International ed. in English, 2020

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DOTAM-Based, Targeted, Activatable Fluorescent Probes for the Highly Sensitive and Selective Detection of Cancer Cells

Bioconjugate chemistry, 2021-04, Vol.32 (4), p.702-712

2021

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Enhanced Properties of a Benzimidazole Benzylpyrazole Lysine Demethylase Inhibitor: Mechanism-of-Action, Binding Site Analysis, and Activity in Cellular Models of Prostate Cancer

Journal of medicinal chemistry, 2021-10, Vol.64 (19), p.14266-14282

2021

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Allosteric Inhibition of a Mammalian Lectin

Journal of the American Chemical Society, 2018-11, Vol.140 (44), p.14915-14925

2018

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A pharmacological master key mechanism that unlocks the selectivity filter gate in K + channels

Science (American Association for the Advancement of Science), 2019-02, Vol.363 (6429), p.875-880

2019

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Preclinical Lead Optimization of a 1,2,4-Triazole Based Tankyrase Inhibitor

Journal of medicinal chemistry, 2020-07, Vol.63 (13), p.6834-6846

2020

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Weizhouochrones: Gorgonian-Derived Symmetric Dimers and Their Structure Elucidation Using Anisotropic NMR Combined with DP4+ Probability and CASE-3D

Journal of natural products (Washington, D.C.), 2022-07, Vol.85 (7), p.1730-1737

2022

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A Palladium-Catalyzed Domino Reaction To Access 3‑Amino‑2H‑indazoles from Hydrazines and 2‑Halobenzonitriles

Organic letters, 2020-09, Vol.22 (18), p.7393-7396

2020

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Discovery of a Novel Series of Tankyrase Inhibitors by a Hybridization Approach

Journal of medicinal chemistry, 2017-12, Vol.60 (24), p.10013-10025

2017

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Identification and Characterization of a Single High‐Affinity Fatty Acid Binding Site in Human Serum Albumin

Angewandte Chemie International Edition, 2018-01, Vol.57 (4), p.1044-1048

International ed. in English, 2018

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Mutant KRAS-driven cancers depend on PTPN11/SHP2 phosphatase

Nature medicine, 2018-07, Vol.24 (7), p.954-960

2018

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Development of a 1,2,4-Triazole-Based Lead Tankyrase Inhibitor: Part II

Journal of medicinal chemistry, 2021-12, Vol.64 (24), p.17936-17949

2021

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Benzo‐Crown‐Ether Functionalized O‐BODIPY Probes for Cations – A Selective Fluorescent Probe for Ba2

Chemistry : a European journal, 2024-08, Vol.30 (45), p.e202401928-n/a

2024

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A General One‐Pot Synthesis of 2H‐Indazoles Using an Organophosphorus–Silane System

Chemistry : a European journal, 2018-06, Vol.24 (36), p.9090-9100

2018

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Structure-Based Design of Xanthine-Benzimidazole Derivatives as Novel and Potent Tryptophan Hydroxylase Inhibitors

Journal of medicinal chemistry, 2022-08, Vol.65 (16), p.11126-11149

2022

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Direct Experimental Evidence for Halogen–Aryl π Interactions in Solution from Molecular Torsion Balances

Angewandte Chemie International Edition, 2017-06, Vol.56 (23), p.6454-6458

2017

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Patent review of cannabinoid receptor type 2 (CB 2 R) modulators (2016-present)

Expert opinion on therapeutic patents, 2024-08, Vol.34 (8), p.665-700

2024

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CellFy: A Cell-Based Fragment Screen against C‑Type Lectins

ACS chemical biology, 2018-12, Vol.13 (12), p.3229-3235

2018

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Aβ Chronic Exposure Promotes an Activation State of Microglia through Endocannabinoid Signalling Imbalance

International journal of molecular sciences, 2023-04, Vol.24 (7), p.6684

2023

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Identification of the Allosteric Binding Site for Thiazolopyrimidine on the C‑Type Lectin Langerin

ACS chemical biology, 2022-10, Vol.17 (10), p.2728-2733

2022

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NMR quality control of fragment libraries for screening

Journal of biomolecular NMR, 2020-11, Vol.74 (10-11), p.555-563

2020

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From Pyrazolones to Azaindoles: Evolution of Active-Site SHP2 Inhibitors Based on Scaffold Hopping and Bioisosteric Replacement

Journal of medicinal chemistry, 2020-12, Vol.63 (23), p.14780-14804

2020

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Small-Molecule Lysophosphatidic Acid Receptor 5 (LPAR5) Antagonists: Versatile Pharmacological Tools to Regulate Inflammatory Signaling in BV-2 Microglia Cells

Frontiers in cellular neuroscience, 2019-11, Vol.13, p.531-531

2019

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Isoform-selective targeting of PI3K: time to consider new opportunities?

Revealing cytotoxic substructures in molecules using deep learning

An Activatable Lanthanide Luminescent Probe for Time‐Gated Detection of Nitroreductase in Live Bacteria

DOTAM-Based, Targeted, Activatable Fluorescent Probes for the Highly Sensitive and Selective Detection of Cancer Cells

Enhanced Properties of a Benzimidazole Benzylpyrazole Lysine Demethylase Inhibitor: Mechanism-of-Action, Binding Site Analysis, and Activity in Cellular Models of Prostate Cancer

Allosteric Inhibition of a Mammalian Lectin

A pharmacological master key mechanism that unlocks the selectivity filter gate in K + channels

Preclinical Lead Optimization of a 1,2,4-Triazole Based Tankyrase Inhibitor

Weizhouochrones: Gorgonian-Derived Symmetric Dimers and Their Structure Elucidation Using Anisotropic NMR Combined with DP4+ Probability and CASE-3D

A Palladium-Catalyzed Domino Reaction To Access 3‑Amino‑2H‑indazoles from Hydrazines and 2‑Halobenzonitriles

Discovery of a Novel Series of Tankyrase Inhibitors by a Hybridization Approach

Identification and Characterization of a Single High‐Affinity Fatty Acid Binding Site in Human Serum Albumin

Mutant KRAS-driven cancers depend on PTPN11/SHP2 phosphatase

Development of a 1,2,4-Triazole-Based Lead Tankyrase Inhibitor: Part II

Benzo‐Crown‐Ether Functionalized O‐BODIPY Probes for Cations – A Selective Fluorescent Probe for Ba2

A General One‐Pot Synthesis of 2H‐Indazoles Using an Organophosphorus–Silane System

Structure-Based Design of Xanthine-Benzimidazole Derivatives as Novel and Potent Tryptophan Hydroxylase Inhibitors

Direct Experimental Evidence for Halogen–Aryl π Interactions in Solution from Molecular Torsion Balances

Patent review of cannabinoid receptor type 2 (CB 2 R) modulators (2016-present)

CellFy: A Cell-Based Fragment Screen against C‑Type Lectins

Aβ Chronic Exposure Promotes an Activation State of Microglia through Endocannabinoid Signalling Imbalance

Identification of the Allosteric Binding Site for Thiazolopyrimidine on the C‑Type Lectin Langerin

NMR quality control of fragment libraries for screening

From Pyrazolones to Azaindoles: Evolution of Active-Site SHP2 Inhibitors Based on Scaffold Hopping and Bioisosteric Replacement

Small-Molecule Lysophosphatidic Acid Receptor 5 (LPAR5) Antagonists: Versatile Pharmacological Tools to Regulate Inflammatory Signaling in BV-2 Microglia Cells

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