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Real-World Evidence for the Safety and Effectiveness of Naldemedine in the Management of Opioid-Induced Constipation in Patients With Cancer Pain: Post-hoc Subgroup Analysis of Post-marketing Surveillance in Japan

Curēus (Palo Alto, CA), 2023-09

2023

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Naldemedine and Magnesium Oxide as First-Line Medications for Opioid-Induced Constipation: A Comparative Database Study in Japanese Patients With Cancer Pain

Curēus (Palo Alto, CA), 2024-03

2024

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Efficacy and safety of guanfacine extended‐release in Japanese adults with attention‐deficit/hyperactivity disorder: Exploratory post hoc subgroup analyses of a randomized, double‐blind, placebo‐controlled study

Neuropsychopharmacology reports, 2021-03, Vol.41 (1), p.26-39

2021

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The Burden of Undiagnosed Adults With Attention-Deficit/Hyperactivity Disorder Symptoms in Japan: A Cross-Sectional Study

Curēus (Palo Alto, CA), 2021-11

2021

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Regulation of Aldosterone and Cortisol Production by the Transcriptional Repressor Neuron Restrictive Silencer Factor

Endocrinology (Philadelphia), 2009-07, Vol.150 (7), p.3110-3117

2009

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Inflammatory response to acute myocardial infarction augments neointimal hyperplasia after vascular injury in a remote artery

Arteriosclerosis, thrombosis, and vascular biology, 2006-09, Vol.26 (9), p.2083-2089

2006

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The Specific Mineralocorticoid Receptor Blocker Eplerenone Attenuates Left Ventricular Remodeling in Mice Lacking the Gene Encoding Guanylyl Cyclase-A

Hypertension research, 2008-06, Vol.31 (6), p.1251-1256

2008

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Inhibitory Effect of Efonidipine on Aldosterone Synthesis and Secretion in Human Adrenocarcinoma (H295R) Cells

Journal of cardiovascular pharmacology, 2006-01, Vol.47 (1), p.133-138

2006

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Design, Synthesis, and Anti-Inflammatory Evaluation of a Novel PPARδ Agonist with a 4‑(1-Pyrrolidinyl)piperidine Structure

Journal of medicinal chemistry, 2023-08, Vol.66 (16), p.11428-11446

2023

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Discovery and structure-activity relationship study of 2-piperazinyl-benzothiazole derivatives as potent and selective PPARδ agonists

Bioorganic & medicinal chemistry, 2023-03, Vol.82, p.117215-117215, Article 117215

2023

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Ultrasound Accelerates Thrombolysis of Acutely Induced Platelet-Rich Thrombi Similar to Those in Acute Myocardial Infarction

Circulation Journal, 2007, Vol.71(10), pp.1643-1648

2007

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Chronic hyperinsulinemia contributes to insulin resistance under dietary restriction in association with altered lipid metabolism in Zucker diabetic fatty rats

American journal of physiology: endocrinology and metabolism, 2017-04, Vol.312 (4), p.E264-E272

2017

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Blocking T-type Ca2+ channels with efonidipine decreased plasma aldosterone concentration in healthy volunteers

Hypertension research, 2006-07, Vol.29 (7), p.493-497

2006

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Design, synthesis and pharmacological evaluation of 3-benzylazetidine-2-one-based human chymase inhibitors

Bioorganic & medicinal chemistry, 2001-11, Vol.9 (11), p.3065-3075

2001

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Efficacy and Safety of Medication for Attention-Deficit Hyperactivity Disorder in Children and Adolescents with Common Comorbidities: A Systematic Review

Neurology and therapy, 2021-12, Vol.10 (2), p.499-522

2021

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High prevalence of severe pain is associated with low opioid availability in patients with advanced cancer: Combined database study and nationwide questionnaire survey in Japan

Neuropsychopharmacology reports, 2024-05, Vol.44 (3), p.502-511

2024

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Total synthesis of human chymase inhibitor methyllinderone and structure–activity relationships of its derivatives

Bioorganic & medicinal chemistry letters, 2001-07, Vol.11 (13), p.1695-1697

2001

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Endothelin generating pathway through endothelin1–31 in human cultured bronchial smooth muscle cells

British journal of pharmacology, 1999-07, Vol.127 (6), p.1415-1421

1999

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Inhibition of serine proteases: activity of 1,3-diazetidine-2,4-diones

Bioorganic & medicinal chemistry letters, 2001-07, Vol.11 (13), p.1691-1694

2001

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Synthesis and structure–activity relationships of a new class of 1-oxacephem-based human chymase inhibitors

Bioorganic & medicinal chemistry letters, 2000-11, Vol.10 (21), p.2397-2401

2000

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A selective peroxisome proliferator-activated receptor δ agonist PYPEP suppresses atherosclerosis in association with improvement of the serum lipoprotein profiles in human apolipoprotein B100 and cholesteryl ester transfer protein double transgenic mice

Metabolism, clinical and experimental, 2016, Vol.65 (1), p.16-25

2016

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1-Oxacephem-based human chymase inhibitors: discovery of stable inhibitors in human plasma

Bioorganic & medicinal chemistry letters, 2000-11, Vol.10 (21), p.2403-2406

2000

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Cardiac Expression of Placental Growth Factor Predicts the Improvement of Chronic Phase Left Ventricular Function in Patients With Acute Myocardial Infarction

Journal of the American College of Cardiology, 2006-04, Vol.47 (8), p.1559-1567

2006

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Blocking T-Type Ca Channels with Efonidipine Decreased Plasma Aldosterone Concentration in Healthy Volunteers

Hypertension research, 2006-07, Vol.29 (7), p.493-497

2006

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Endothelin generating pathway through endothelin 1–31 in human cultured bronchial smooth muscle cells

British journal of pharmacology, 2009-01, Vol.127 (6), p.1415-1421

2009

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Real-World Evidence for the Safety and Effectiveness of Naldemedine in the Management of Opioid-Induced Constipation in Patients With Cancer Pain: Post-hoc Subgroup Analysis of Post-marketing Surveillance in Japan

Naldemedine and Magnesium Oxide as First-Line Medications for Opioid-Induced Constipation: A Comparative Database Study in Japanese Patients With Cancer Pain

Efficacy and safety of guanfacine extended‐release in Japanese adults with attention‐deficit/hyperactivity disorder: Exploratory post hoc subgroup analyses of a randomized, double‐blind, placebo‐controlled study

The Burden of Undiagnosed Adults With Attention-Deficit/Hyperactivity Disorder Symptoms in Japan: A Cross-Sectional Study

Regulation of Aldosterone and Cortisol Production by the Transcriptional Repressor Neuron Restrictive Silencer Factor

Inflammatory response to acute myocardial infarction augments neointimal hyperplasia after vascular injury in a remote artery

The Specific Mineralocorticoid Receptor Blocker Eplerenone Attenuates Left Ventricular Remodeling in Mice Lacking the Gene Encoding Guanylyl Cyclase-A

Inhibitory Effect of Efonidipine on Aldosterone Synthesis and Secretion in Human Adrenocarcinoma (H295R) Cells

Design, Synthesis, and Anti-Inflammatory Evaluation of a Novel PPARδ Agonist with a 4‑(1-Pyrrolidinyl)piperidine Structure

Discovery and structure-activity relationship study of 2-piperazinyl-benzothiazole derivatives as potent and selective PPARδ agonists

Ultrasound Accelerates Thrombolysis of Acutely Induced Platelet-Rich Thrombi Similar to Those in Acute Myocardial Infarction

Chronic hyperinsulinemia contributes to insulin resistance under dietary restriction in association with altered lipid metabolism in Zucker diabetic fatty rats

Blocking T-type Ca2+ channels with efonidipine decreased plasma aldosterone concentration in healthy volunteers

Design, synthesis and pharmacological evaluation of 3-benzylazetidine-2-one-based human chymase inhibitors

Efficacy and Safety of Medication for Attention-Deficit Hyperactivity Disorder in Children and Adolescents with Common Comorbidities: A Systematic Review

High prevalence of severe pain is associated with low opioid availability in patients with advanced cancer: Combined database study and nationwide questionnaire survey in Japan

Total synthesis of human chymase inhibitor methyllinderone and structure–activity relationships of its derivatives

Endothelin generating pathway through endothelin1–31 in human cultured bronchial smooth muscle cells

Inhibition of serine proteases: activity of 1,3-diazetidine-2,4-diones

Synthesis and structure–activity relationships of a new class of 1-oxacephem-based human chymase inhibitors

A selective peroxisome proliferator-activated receptor δ agonist PYPEP suppresses atherosclerosis in association with improvement of the serum lipoprotein profiles in human apolipoprotein B100 and cholesteryl ester transfer protein double transgenic mice

1-Oxacephem-based human chymase inhibitors: discovery of stable inhibitors in human plasma

Cardiac Expression of Placental Growth Factor Predicts the Improvement of Chronic Phase Left Ventricular Function in Patients With Acute Myocardial Infarction

Blocking T-Type Ca Channels with Efonidipine Decreased Plasma Aldosterone Concentration in Healthy Volunteers

Endothelin generating pathway through endothelin 1–31 in human cultured bronchial smooth muscle cells

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