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Structure-Based Design of Orally Bioavailable 1H‑Pyrrolo[3,2‑c]pyridine Inhibitors of Mitotic Kinase Monopolar Spindle 1 (MPS1)

Journal of medicinal chemistry, 2013-12, Vol.56 (24), p.10045-10065

2013

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High Proliferation Rate and a Compromised Spindle Assembly Checkpoint Confers Sensitivity to the MPS1 Inhibitor BOS172722 in Triple-Negative Breast Cancers

Molecular cancer therapeutics, 2019-10, Vol.18 (10), p.1696-1707

2019

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Rapid Discovery of Pyrido[3,4‑d]pyrimidine Inhibitors of Monopolar Spindle Kinase 1 (MPS1) Using a Structure-Based Hybridization Approach

Journal of medicinal chemistry, 2016-04, Vol.59 (8), p.3671-3688

2016

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Characterisation of CCT271850, a selective, oral and potent MPS1 inhibitor, used to directly measure in vivo MPS1 inhibition vs therapeutic efficacy

British journal of cancer, 2017-04, Vol.116 (9), p.1166-1176

2017

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Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance

Cancer research (Chicago, Ill.), 2015-08, Vol.75 (16), p.3340-3354

2015

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Ring Contraction Methodology for the Synthesis of Pyrroles

Current organic chemistry, 2005-02, Vol.9 (3), p.261-288

2005

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Synthesis of Spiroacetal Enol Ethers by Oxidative Activation of Furan Derivatives

Organic letters, 2008-12, Vol.10 (23), p.5445-5448

2008

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Synthesis of Polyhydroxylated Pyrano-Pyrrole Derivatives from Carbohydrate Precursors

European Journal of Organic Chemistry, 2007-07, Vol.2007 (20), p.3296-3310

2007

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Synthesis of Novel Polyhydroxylated Tetrahydropyranopyrroles

Synlett, 2007-02, Vol.2007 (3), p.0403-0406

2007

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Synthesis of Pyrenolide D Analogues

Synlett, 2008-08, Vol.2008 (14), p.2083-2086

2008

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Conformational preferences of oxy-substituents in butenolide-tetrahydropyran spiroacetals and butenolide-piperidine spiro-N,O-acetals

Organic & biomolecular chemistry, 2012-05, Vol.10 (17), p.3506-3518

2012

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Abstract 4036: Induction of detrimental aneuploidy in basal breast cancer cells treated by MPS1 inhibitors in combination with paclitaxel

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.4036-4036

2017

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Identification and characterisation of 2-aminopyridine inhibitors of checkpoint kinase 2

Bioorganic & medicinal chemistry, 2010-01, Vol.18 (2), p.707-718

2010

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Structure-Based Design of Orally Bioavailable 1 H -Pyrrolo[3,2- c ]pyridine Inhibitors of Mitotic Kinase Monopolar Spindle 1 (MPS1)

Journal of medicinal chemistry, 2013-12, Vol.56 (24), p.10045-10065

2013

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Corrigendum to “Identification and characterisation of 2-aminopyridine inhibitors of checkpoint kinase 2” [Bioorg. Med. Chem. 18 (2010) 707]

Bioorganic & medicinal chemistry, 2010-06, Vol.18 (12), p.4591-4591

2010

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Abstract 1651: In vitro and in vivo profile of the preclinical candidate and MPS1 kinase inhibitor CCT289346

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.1651-1651

2018

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Abstract 193: Inhibitors of MPS1: Discovery of CCT289346, a highly potent, selective and orally available preclinical candidate

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.193-193

2017

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Dimethyl 1,2,4,5-Tetrazine-3,6-dicarboxylate

Synlett, 2004-12, Vol.2004 (15), p.2836-2837

Naud, Sébastien

2004

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Abstract 5450: Naturally occurring mutations in the MPS1 gene predispose cells to kinase inhibitor drug-resistance

Cancer research (Chicago, Ill.), 2015-08, Vol.75 (15_Supplement), p.5450-5450

2015

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Abstract 3642: Structure enabled design of inhibitors of the mitotic kinase MPS1

Cancer research (Chicago, Ill.), 2015-08, Vol.75 (15_Supplement), p.3642-3642

2015

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Unusual anomeric rearrangement of para-nitrobenzoylxanthate d-glycosides: a new direct stereoselective access to α-thioglycosides from pyranose sugars

Tetrahedron, 2006-05, Vol.62 (20), p.4784-4794

2006

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ChemInform Abstract: Synthesis of Pyrenolide D (III) Analogues

ChemInform, 2008-12, Vol.39 (51), p.no-no

2008

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Ring Contraction Methodology for the Synthesis of Pyrroles

ChemInform, 2005-11, Vol.36 (47), p.no-no

2005

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Revealing the finite-frequency response of a bosonic quantum impurity

SciPost physics, 2023-05, Vol.14 (5), p.130, Article 130

2023

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Synthesis of Novel Polyhydroxylated Tetrahydropyranopyrroles

ChemInform, 2007-06, Vol.38 (26), p.no-no

2007

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Structure-Based Design of Orally Bioavailable 1H‑Pyrrolo[3,2‑c]pyridine Inhibitors of Mitotic Kinase Monopolar Spindle 1 (MPS1)

High Proliferation Rate and a Compromised Spindle Assembly Checkpoint Confers Sensitivity to the MPS1 Inhibitor BOS172722 in Triple-Negative Breast Cancers

Rapid Discovery of Pyrido[3,4‑d]pyrimidine Inhibitors of Monopolar Spindle Kinase 1 (MPS1) Using a Structure-Based Hybridization Approach

Characterisation of CCT271850, a selective, oral and potent MPS1 inhibitor, used to directly measure in vivo MPS1 inhibition vs therapeutic efficacy

Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance

Ring Contraction Methodology for the Synthesis of Pyrroles

Synthesis of Spiroacetal Enol Ethers by Oxidative Activation of Furan Derivatives

Synthesis of Polyhydroxylated Pyrano-Pyrrole Derivatives from Carbohydrate Precursors

Synthesis of Novel Polyhydroxylated Tetrahydropyranopyrroles

Synthesis of Pyrenolide D Analogues

Conformational preferences of oxy-substituents in butenolide-tetrahydropyran spiroacetals and butenolide-piperidine spiro-N,O-acetals

Abstract 4036: Induction of detrimental aneuploidy in basal breast cancer cells treated by MPS1 inhibitors in combination with paclitaxel

Identification and characterisation of 2-aminopyridine inhibitors of checkpoint kinase 2

Structure-Based Design of Orally Bioavailable 1 H -Pyrrolo[3,2- c ]pyridine Inhibitors of Mitotic Kinase Monopolar Spindle 1 (MPS1)

Corrigendum to “Identification and characterisation of 2-aminopyridine inhibitors of checkpoint kinase 2” [Bioorg. Med. Chem. 18 (2010) 707]

Abstract 1651: In vitro and in vivo profile of the preclinical candidate and MPS1 kinase inhibitor CCT289346

Abstract 193: Inhibitors of MPS1: Discovery of CCT289346, a highly potent, selective and orally available preclinical candidate

Dimethyl 1,2,4,5-Tetrazine-3,6-dicarboxylate

Abstract 5450: Naturally occurring mutations in the MPS1 gene predispose cells to kinase inhibitor drug-resistance

Abstract 3642: Structure enabled design of inhibitors of the mitotic kinase MPS1

Unusual anomeric rearrangement of para-nitrobenzoylxanthate d-glycosides: a new direct stereoselective access to α-thioglycosides from pyranose sugars

ChemInform Abstract: Synthesis of Pyrenolide D (III) Analogues

Ring Contraction Methodology for the Synthesis of Pyrroles

Revealing the finite-frequency response of a bosonic quantum impurity

Synthesis of Novel Polyhydroxylated Tetrahydropyranopyrroles

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