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Inhibition of glucosylceramide accumulation results in effective blockade of polycystic kidney disease in mouse models

Nature medicine, 2010-07, Vol.16 (7), p.788-792

2010

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CaMKII as a pathological mediator of ER stress, oxidative stress, and mitochondrial dysfunction in a murine model of nephronophthisis

American journal of physiology. Renal physiology, 2016-06, Vol.310 (11), p.F1414-F1422

2016

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VEPTP inhibition with an extracellular domain targeting antibody did not restore albuminuria in a mouse model of diabetic kidney disease

Physiological reports, 2024-09, Vol.12 (18), p.e70058-n/a

2024

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CDK inhibitors R-roscovitine and S-CR8 effectively block renal and hepatic cystogenesis in an orthologous model of ADPKD

Cell cycle (Georgetown, Tex.), 2012-11, Vol.11 (21), p.4040-4046

2012

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Glucosylceramide synthase modulation ameliorates murine renal pathologies and promotes macrophage effector function in vitro

Communications biology, 2024-08, Vol.7 (1), p.932-15, Article 932

2024

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Glycosphingolipid metabolism and polycystic kidney disease

Cellular signalling, 2020-05, Vol.69, p.109526-109526, Article 109526

2020

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mTOR signaling in polycystic kidney disease

Trends in molecular medicine, 2011-11, Vol.17 (11), p.625-633

2011

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Pkd1 and Nek8 mutations affect cell-cell adhesion and cilia in cysts formed in kidney organ cultures

American journal of physiology. Renal physiology, 2008-01, Vol.294 (1), p.F73-F83

2008

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Correction of cilia structure and function alleviates multi-organ pathology in Bardet–Biedl syndrome mice

Human molecular genetics, 2020-08, Vol.29 (15), p.2508-2522

2020

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Role of the WT1 tumor suppressor in murine hematopoiesis

Blood, 2003-04, Vol.101 (7), p.2570-2574

2003

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A Mammal-Specific Exon of WT1 Is Not Required for Development or Fertility

Molecular and Cellular Biology, 2002-06, Vol.22 (12), p.4433-4438

2002

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Wt1 functions in the development of germ cells in addition to somatic cell lineages of the testis

Developmental biology, 2004-04, Vol.268 (2), p.429-440

2004

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Loss of GM3 synthase gene, but not sphingosine kinase 1, is protective against murine nephronophthisis-related polycystic kidney disease

Human molecular genetics, 2012-08, Vol.21 (15), p.3397-3407

2012

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Differences in the timing and magnitude of Pkd1 gene deletion determine the severity of polycystic kidney disease in an orthologous mouse model of ADPKD

Physiological reports, 2016-06, Vol.4 (12), p.e12846-n/a

2016

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A mutant form of the Wilms' tumor suppressor gene WT1 observed in Denys-Drash syndrome interferes with glomerular capillary development

Journal of the American Society of Nephrology, 2002-08, Vol.13 (8), p.2058-2067

2002

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Effects of a Vascular Endothelial Protein Tyrosine Phosphatase (VE-PTP) Blocking Antibody in a Mouse Model of Severe Diabetic Kidney Disease: FR-PO334

Journal of the American Society of Nephrology, 2023-11, Vol.34 (11S), p.496-496

2023

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Effects of KCNN4 Blockade With Senicapoc in Kidney Cell-Based Assays and a Mouse Model of Renal Inflammation and Fibrosis: FR-PO237

Journal of the American Society of Nephrology, 2022-11, Vol.33 (11S), p.391-391

2022

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Integrin α3β1 as a Potential Target for Diabetic Kidney Disease (DKD): SA-PO1006

Journal of the American Society of Nephrology, 2023-11, Vol.34 (11S), p.1011-1011

2023

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Glucosylceramide Synthase Inhibition Preserves Mitochondrial Function and Reduces Reactive Oxygen Damage in the Jck Mouse Model of Polycystic Kidney Disease: PO1561

Journal of the American Society of Nephrology, 2020-10, Vol.31 (10S), p.497-497

2020

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Spatial Mapping of Murine Diabetic Kidney Disease (DKD) Transcriptomics at Single-Cell Resolution: FR-OR15

Journal of the American Society of Nephrology, 2021-10, Vol.32 (10S), p.25-26

2021

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Hox/Pbx and Brn binding sites mediate Pax3 expression in vitro and in vivo

Gene Expression Patterns, 2004-10, Vol.4 (6), p.671-685

2004

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Pkdl and Nek8 mutations affect cell-cell adhesion and cilia in cysts formed in kidney organ cultures

American journal of physiology. Renal physiology, 2008, Vol.63 (1)

2008

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Initial differentiation of the metanephric mesenchyme is independent of WT1 and the ureteric bud

Developmental genetics, 1999, Vol.24 (3-4), p.252-262

1999

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Positive and negative DNA sequence elements are required to establish the pattern of Pax3 expression

Development (Cambridge), 1997-02, Vol.124 (3), p.617-626

1997

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Coordinate action of Wt1 and a modifier gene supports embryonic survival in the oviduct

Molecular reproduction and development, 1999-04, Vol.52 (4), p.366-375

1999

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Inhibition of glucosylceramide accumulation results in effective blockade of polycystic kidney disease in mouse models

CaMKII as a pathological mediator of ER stress, oxidative stress, and mitochondrial dysfunction in a murine model of nephronophthisis

VEPTP inhibition with an extracellular domain targeting antibody did not restore albuminuria in a mouse model of diabetic kidney disease

CDK inhibitors R-roscovitine and S-CR8 effectively block renal and hepatic cystogenesis in an orthologous model of ADPKD

Glucosylceramide synthase modulation ameliorates murine renal pathologies and promotes macrophage effector function in vitro

Glycosphingolipid metabolism and polycystic kidney disease

mTOR signaling in polycystic kidney disease

Pkd1 and Nek8 mutations affect cell-cell adhesion and cilia in cysts formed in kidney organ cultures

Correction of cilia structure and function alleviates multi-organ pathology in Bardet–Biedl syndrome mice

Role of the WT1 tumor suppressor in murine hematopoiesis

A Mammal-Specific Exon of WT1 Is Not Required for Development or Fertility

Wt1 functions in the development of germ cells in addition to somatic cell lineages of the testis

Loss of GM3 synthase gene, but not sphingosine kinase 1, is protective against murine nephronophthisis-related polycystic kidney disease

Differences in the timing and magnitude of Pkd1 gene deletion determine the severity of polycystic kidney disease in an orthologous mouse model of ADPKD

A mutant form of the Wilms' tumor suppressor gene WT1 observed in Denys-Drash syndrome interferes with glomerular capillary development

Effects of a Vascular Endothelial Protein Tyrosine Phosphatase (VE-PTP) Blocking Antibody in a Mouse Model of Severe Diabetic Kidney Disease: FR-PO334

Effects of KCNN4 Blockade With Senicapoc in Kidney Cell-Based Assays and a Mouse Model of Renal Inflammation and Fibrosis: FR-PO237

Integrin α3β1 as a Potential Target for Diabetic Kidney Disease (DKD): SA-PO1006

Glucosylceramide Synthase Inhibition Preserves Mitochondrial Function and Reduces Reactive Oxygen Damage in the Jck Mouse Model of Polycystic Kidney Disease: PO1561

Spatial Mapping of Murine Diabetic Kidney Disease (DKD) Transcriptomics at Single-Cell Resolution: FR-OR15

Hox/Pbx and Brn binding sites mediate Pax3 expression in vitro and in vivo

Pkdl and Nek8 mutations affect cell-cell adhesion and cilia in cysts formed in kidney organ cultures

Initial differentiation of the metanephric mesenchyme is independent of WT1 and the ureteric bud

Positive and negative DNA sequence elements are required to establish the pattern of Pax3 expression

Coordinate action of Wt1 and a modifier gene supports embryonic survival in the oviduct

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