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Modulating Protein-Protein Interactions of the Mitotic Polo-like Kinases to Target Mutant KRAS

Cell chemical biology, 2017-08, Vol.24 (8), p.1017-1028.e7

2017

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Identification of a quality-control factor that monitors failures during proteasome assembly

Science (American Association for the Advancement of Science), 2021-08, Vol.373 (6558), p.998-1004

2021

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LSD1 overexpression is associated with poor prognosis in basal-like breast cancer, and sensitivity to PARP inhibition

PloS one, 2015-02, Vol.10 (2), p.e0118002-e0118002

2015

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Development of a Novel Cell-Permeable Protein–Protein Interaction Inhibitor for the Polo-box Domain of Polo-like Kinase 1

ACS omega, 2020-01, Vol.5 (1), p.822-831

2020

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Allosteric modulation of AURKA kinase activity by a small-molecule inhibitor of its protein-protein interaction with TPX2

Scientific reports, 2016-06, Vol.6 (1), p.28528, Article 28528

2016

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Structural and Molecular Insight into Resistance Mechanisms of First Generation cMET Inhibitors

ACS medicinal chemistry letters, 2019-09, Vol.10 (9), p.1322-1327

2019

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Positioning High-Throughput CETSA in Early Drug Discovery through Screening against B-Raf and PARP1

SLAS discovery, 2019-02, Vol.24 (2), p.121-132

2019

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Computational analysis of phosphopeptide binding to the polo-box domain of the mitotic kinase PLK1 using molecular dynamics simulation

PLoS computational biology, 2010-08, Vol.6 (8), p.e1000880

2010

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NF-κB signaling mediates acquired resistance after PARP inhibition

Oncotarget, 2015-02, Vol.6 (6), p.3825-3839

2015

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Abstract LB-273: A head-to-head comparison of the properties of five clinical PARP inhibitors identifies new insights that can explain both the observed clinical efficacy and safety profiles

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.LB-273-LB-273

2018

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The Involvement of Arg super(265) of Mouse Ribonucleotide Reductase R2 Protein in Proton Transfer and Catalysis

The Journal of biological chemistry, 2006-09, Vol.281 (36), p.26022-26028

2006

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The Involvement of Arg265 of Mouse Ribonucleotide Reductase R2 Protein in Proton Transfer and Catalysis

The Journal of biological chemistry, 2006-09, Vol.281 (36), p.26022-26028

2006

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Computational Analysis of Phosphopeptide Binding to the Polo-Box Domain of the Mitotic Kinase PLK1 Using Molecular Dynamics Simulation: e1000880

PLoS computational biology, 2010-08, Vol.6 (8)

2010

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Pembrolizumab for Persistent, Recurrent, or Metastatic Cervical Cancer

The New England journal of medicine, 2021-11, Vol.385 (20), p.1856-1867

2021

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Identification of optimal therapeutic window for steroid use in severe alcohol-associated hepatitis: A worldwide study

Journal of hepatology, 2021-11, Vol.75 (5), p.1026-1033

2021

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Analysis of inpatient data on dengue fever, malaria and leishmaniasis in Ecuador: A cross-sectional national study, 2015–2022

New microbes and new infections, 2024-08, Vol.60-61, p.101421, Article 101421

2024

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Maternal and neonatal individual risks and benefits associated with caesarean delivery: multicentre prospective study

BMJ (British Medical Journal), 2007-11, Vol.335 (7628), p.1025-1029

International edition, 2007

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A Connectivity Strategy for the Evaluation of Smart Grid Models Based on the Ethernet Technology

Revista IEEE América Latina, 2024-07, Vol.22 (7), p.581-590

2024

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Caesarean delivery rates and pregnancy outcomes: the 2005 WHO global survey on maternal and perinatal health in Latin America

The Lancet (British edition), 2006-06, Vol.367 (9525), p.1819-1829

2006

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Semi-Solid Dosage Forms Containing Pranoprofen-Loaded NLC as Topical Therapy for Local Inflammation: In Vitro, Ex Vivo and In Vivo Evaluation

Gels, 2023-05, Vol.9 (6), p.448

2023

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Chemical and nano-mineralogical study for determining potential uses of legal Colombian gold mine sludge: Experimental evidence

Chemosphere (Oxford), 2018-01, Vol.191, p.1048-1055

2018

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Investigation of a Reduction in Tylosin on the Prevalence of Liver Abscesses and Antimicrobial Resistance in Enterococci in Feedlot Cattle

Frontiers in veterinary science, 2020-02, Vol.7, p.90-90

2020

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Modulating Protein-Protein Interactions of the Mitotic Polo-like Kinases to Target Mutant KRAS

Identification of a quality-control factor that monitors failures during proteasome assembly

LSD1 overexpression is associated with poor prognosis in basal-like breast cancer, and sensitivity to PARP inhibition

Development of a Novel Cell-Permeable Protein–Protein Interaction Inhibitor for the Polo-box Domain of Polo-like Kinase 1

Allosteric modulation of AURKA kinase activity by a small-molecule inhibitor of its protein-protein interaction with TPX2

Structural and Molecular Insight into Resistance Mechanisms of First Generation cMET Inhibitors

Positioning High-Throughput CETSA in Early Drug Discovery through Screening against B-Raf and PARP1

Computational analysis of phosphopeptide binding to the polo-box domain of the mitotic kinase PLK1 using molecular dynamics simulation

NF-κB signaling mediates acquired resistance after PARP inhibition

Abstract LB-273: A head-to-head comparison of the properties of five clinical PARP inhibitors identifies new insights that can explain both the observed clinical efficacy and safety profiles

The Involvement of Arg super(265) of Mouse Ribonucleotide Reductase R2 Protein in Proton Transfer and Catalysis

The Involvement of Arg265 of Mouse Ribonucleotide Reductase R2 Protein in Proton Transfer and Catalysis

Computational Analysis of Phosphopeptide Binding to the Polo-Box Domain of the Mitotic Kinase PLK1 Using Molecular Dynamics Simulation: e1000880

Pembrolizumab for Persistent, Recurrent, or Metastatic Cervical Cancer

Identification of optimal therapeutic window for steroid use in severe alcohol-associated hepatitis: A worldwide study

Analysis of inpatient data on dengue fever, malaria and leishmaniasis in Ecuador: A cross-sectional national study, 2015–2022

Maternal and neonatal individual risks and benefits associated with caesarean delivery: multicentre prospective study

A Connectivity Strategy for the Evaluation of Smart Grid Models Based on the Ethernet Technology

C-reactive protein cut-off for early tocilizumab and dexamethasone prescription in hospitalized patients with COVID-19

Validation study of genetic biomarkers of response to TNF inhibitors in rheumatoid arthritis

Caesarean delivery rates and pregnancy outcomes: the 2005 WHO global survey on maternal and perinatal health in Latin America

Semi-Solid Dosage Forms Containing Pranoprofen-Loaded NLC as Topical Therapy for Local Inflammation: In Vitro, Ex Vivo and In Vivo Evaluation

Chemical and nano-mineralogical study for determining potential uses of legal Colombian gold mine sludge: Experimental evidence

Investigation of a Reduction in Tylosin on the Prevalence of Liver Abscesses and Antimicrobial Resistance in Enterococci in Feedlot Cattle

Impact of SARS-CoV-2 viral load and duration of symptoms before hospital admission on the mortality of hospitalized COVID-19 patients

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