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Nanomole-scale high-throughput chemistry for the synthesis of complex molecules

Science (American Association for the Advancement of Science), 2015-01, Vol.347 (6217), p.49-53

2015

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Synthesis of Complex Druglike Molecules by the Use of Highly Functionalized Bench-Stable Organozinc Reagents

Angewandte Chemie International Edition, 2016-10, Vol.55 (44), p.13714-13718

International ed. in English, 2016

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Neutralization of Pathogenic Fungi with Small‐Molecule Immunotherapeutics

Angewandte Chemie International Edition, 2017-10, Vol.56 (42), p.13036-13040

International ed. in English, 2017

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Reaction: The Art of Synthetic Chemistry

Chem, 2016-09, Vol.1 (3), p.335-336

Nantermet, Philippe G.

2016

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Modeling a Crowdsourced Definition of Molecular Complexity

Journal of chemical information and modeling, 2014-06, Vol.54 (6), p.1604-1616

2014

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Discovery of Oxadiazoyl Tertiary Carbinamine Inhibitors of β-Secretase (BACE-1)

Journal of medicinal chemistry, 2006-12, Vol.49 (25), p.7270-7273

2006

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Neutralization of Pathogenic Fungi with Small‐Molecule Immunotherapeutics

Angewandte Chemie, 2017-10, Vol.129 (42), p.13216-13220

2017

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Attenuation of scratch‐induced reactive astrogliosis by novel EphA4 kinase inhibitors

Journal of neurochemistry, 2011-09, Vol.118 (6), p.1016-1031

2011

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Discovery and Evaluation of Potent P1 Aryl Heterocycle-Based Thrombin Inhibitors

Journal of medicinal chemistry, 2004-06, Vol.47 (12), p.2995-3008

2004

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Design, synthesis, and SAR of macrocyclic tertiary carbinamine BACE-1 inhibitors

Bioorganic & medicinal chemistry letters, 2007-07, Vol.17 (14), p.4057-4061

2007

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Rapid P1 SAR of brain penetrant tertiary carbinamine derived BACE inhibitors

Bioorganic & medicinal chemistry letters, 2010-03, Vol.20 (5), p.1779-1782

2010

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A facile three-step synthesis of 1,2-amino alcohols using the Ellman homochiral tert-butylsulfinamide

Tetrahedron letters, 2001-03, Vol.42 (11), p.2051-2054

2001

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SAR of tertiary carbinamine derived BACE1 inhibitors: Role of aspartate ligand amine pKa in enzyme inhibition

Bioorganic & medicinal chemistry letters, 2010-03, Vol.20 (6), p.1885-1889

2010

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Discovery and SAR of isonicotinamide BACE-1 inhibitors that bind β-secretase in a N-terminal 10s-loop down conformation

Bioorganic & medicinal chemistry letters, 2007-03, Vol.17 (6), p.1788-1792

2007

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Strategies toward improving the brain penetration of macrocyclic tertiary carbinamine BACE-1 inhibitors

Bioorganic & medicinal chemistry letters, 2007-11, Vol.17 (21), p.5831-5835

2007

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β-Secretase (BACE-1) inhibitors: Accounting for 10s loop flexibility using rigid active sites

Bioorganic & medicinal chemistry letters, 2007-02, Vol.17 (4), p.1117-1121

2007

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The Total Synthesis of (±)-Ginkgolide B

Journal of the American Chemical Society, 2000-09, Vol.122 (35), p.8453-8463

2000

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Synthesis of Complex Druglike Molecules by the Use of Highly Functionalized Bench-Stable Organozinc Reagents

Angewandte Chemie, 2016-10, Vol.128 (44), p.13918-13922

2016

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Imidazole acetic acid TAFIa inhibitors: SAR studies centered around the basic P 1 ′ group

Bioorganic & medicinal chemistry letters, 2004-05, Vol.14 (9), p.2141-2145

2004

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9-Hydroxyazafluorenes and Their Use in Thrombin Inhibitors

Journal of medicinal chemistry, 2005-04, Vol.48 (7), p.2282-2293

2005

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Strategies towards Improving the Pharmacokinetic Profile of ε-Substituted Lysinol-Derived HIV Protease Inhibitors

ChemMedChem, 2011-02, Vol.6 (2), p.253-257

2011

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Evolution of Tertiary Carbinamine BACE‐1 Inhibitors: Aβ Reduction in Rhesus CSF upon Oral Dosing

ChemMedChem, 2009-01, Vol.4 (1), p.37-40

2009

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Synthesis and Evaluation of Imidazole Acetic Acid Inhibitors of Activated Thrombin-Activatable Fibrinolysis Inhibitor as Novel Antithrombotics

Journal of medicinal chemistry, 2003-12, Vol.46 (25), p.5294-5297

2003

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Nanomole-scale high-throughput chemistry for the synthesis of complex molecules

Synthesis of Complex Druglike Molecules by the Use of Highly Functionalized Bench-Stable Organozinc Reagents

Neutralization of Pathogenic Fungi with Small‐Molecule Immunotherapeutics

Reaction: The Art of Synthetic Chemistry

Modeling a Crowdsourced Definition of Molecular Complexity

Discovery of MK-8718, an HIV Protease Inhibitor Containing a Novel Morpholine Aspartate Binding Group

Discovery of Oxadiazoyl Tertiary Carbinamine Inhibitors of β-Secretase (BACE-1)

Neutralization of Pathogenic Fungi with Small‐Molecule Immunotherapeutics

Attenuation of scratch‐induced reactive astrogliosis by novel EphA4 kinase inhibitors

Discovery and Evaluation of Potent P1 Aryl Heterocycle-Based Thrombin Inhibitors

Design, synthesis, and SAR of macrocyclic tertiary carbinamine BACE-1 inhibitors

Rapid P1 SAR of brain penetrant tertiary carbinamine derived BACE inhibitors

A facile three-step synthesis of 1,2-amino alcohols using the Ellman homochiral tert-butylsulfinamide

SAR of tertiary carbinamine derived BACE1 inhibitors: Role of aspartate ligand amine pKa in enzyme inhibition

Discovery and SAR of isonicotinamide BACE-1 inhibitors that bind β-secretase in a N-terminal 10s-loop down conformation

Strategies toward improving the brain penetration of macrocyclic tertiary carbinamine BACE-1 inhibitors

β-Secretase (BACE-1) inhibitors: Accounting for 10s loop flexibility using rigid active sites

The Total Synthesis of (±)-Ginkgolide B

Synthesis of Complex Druglike Molecules by the Use of Highly Functionalized Bench-Stable Organozinc Reagents

Imidazole acetic acid TAFIa inhibitors: SAR studies centered around the basic P 1 ′ group

9-Hydroxyazafluorenes and Their Use in Thrombin Inhibitors

Strategies towards Improving the Pharmacokinetic Profile of ε-Substituted Lysinol-Derived HIV Protease Inhibitors

Evolution of Tertiary Carbinamine BACE‐1 Inhibitors: Aβ Reduction in Rhesus CSF upon Oral Dosing

Synthesis and Evaluation of Imidazole Acetic Acid Inhibitors of Activated Thrombin-Activatable Fibrinolysis Inhibitor as Novel Antithrombotics

Pharmacokinetic optimization of 3-amino-6-chloropyrazinone acetamide thrombin inhibitors. implementation of P3 pyridine N-Oxides to deliver an orally bioavailable series containing P1 N-Benzylamides

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