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A new generation Mpro inhibitor with potent activity against SARS-CoV-2 Omicron variants

Signal transduction and targeted therapy, 2023-03, Vol.8 (1), p.128-13, Article 128

2023

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Discovery and structure-activity relationship studies of 1-aryl-1H-naphtho[2,3-d][1,2,3]triazole-4,9-dione derivatives as potent dual inhibitors of indoleamine 2,3-dioxygenase 1 (IDO1) and trytophan 2,3-dioxygenase (TDO)

European journal of medicinal chemistry, 2020-12, Vol.207, p.112703-112703, Article 112703

2020

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Discovery of (S)-3-(4-(benzyloxy)phenyl)-2-(2-phenoxyacetamido)propanoic acid derivatives as a new class of GPR34 antagonists

Bioorganic & medicinal chemistry letters, 2024-01, Vol.97, p.129548-129548, Article 129548

2024

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Discovery of a novel and potent inhibitor with differential species-specific effects against NLRP3 and AIM2 inflammasome-dependent pyroptosis

European journal of medicinal chemistry, 2022-03, Vol.232, p.114194-114194, Article 114194

2022

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Targeting Noncanonical Pyroptosis With a Small Molecular Inhibitor Alleviates Inflammation in the LPS-Induced Keratitis Mouse Model

Investigative ophthalmology & visual science, 2023-01, Vol.64 (1), p.1

2023

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Structural Optimization and Structure-Activity Relationship Studies of 6,6-Dimethyl-4-(phenylamino)-6H-pyrimido[5,4-b][1,4]oxazin-7(8H)-one Derivatives as A New Class of Potent Inhibitors of Pan-Trk and Their Drug-Resistant Mutants

Journal of medicinal chemistry, 2022-02, Vol.65 (3), p.2035-2058

2022

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Structural Optimization and Structure-Activity Relationship Studies of 6,6-Dimethyl-4-(phenylamino)-6 H -pyrimido[5,4- b ][1,4]oxazin-7(8 H )-one Derivatives as A New Class of Potent Inhibitors of Pan-Trk and Their Drug-Resistant Mutants

Journal of medicinal chemistry, 2022-02, Vol.65 (3), p.2035-2058

2022

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Discovery of a novel pyroptosis inhibitor acting though modulating glutathionylation to suppress NLRP3-related signal pathway

International immunopharmacology, 2024-01, Vol.127, p.111314-111314, Article 111314

2024

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Discovery of a potent and highly selective inhibitor of ataxia telangiectasia mutated and Rad3-Related (ATR) kinase: Structural activity relationship and antitumor activity both in vitro and in vivo

European journal of medicinal chemistry, 2022-03, Vol.232, p.114187-114187, Article 114187

2022

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Discovery of 4‑(1,2,4-Oxadiazol-5-yl)azepan-2-one Derivatives as a New Class of Cannabinoid Type 2 Receptor Agonists for the Treatment of Inflammatory Pain

Journal of medicinal chemistry, 2023-03, Vol.66 (5), p.3460-3483

2023

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Entropy drives the ligand recognition in G-protein-coupled receptor subtypes

Proceedings of the National Academy of Sciences - PNAS, 2024-07, Vol.121 (30), p.e2401091121

2024

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Discovery of small molecule FLT3 inhibitors that are able to overcome drug-resistant mutations

Bioorganic & medicinal chemistry letters, 2020-11, Vol.30 (22), p.127532-127532, Article 127532

2020

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A new generation M pro inhibitor with potent activity against SARS-CoV-2 Omicron variants

Signal transduction and targeted therapy, 2023-03, Vol.8 (1), p.128

2023

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Progressive global perception and local polishing network for lung infection segmentation of COVID-19 CT images

Pattern recognition, 2021-12, Vol.120, p.108168-108168, Article 108168

2021

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An attention residual u-net with differential preprocessing and geometric postprocessing: Learning how to segment vasculature including intracranial aneurysms

Medical image analysis, 2023-02, Vol.84, p.102697-102697, Article 102697

2023

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An Experimental Investigation on the Dynamic Response of Buried RC Pipes Induced by Falling Impact

Sensors (Basel, Switzerland), 2024-01, Vol.24 (3), p.929

2024

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Fully Convolutional Network and Visual Saliency-Based Automatic Optic Disc Detection in Retinal Fundus Images

Journal of healthcare engineering, 2021-08, Vol.2021, p.3561134-11

2021

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Identification and analysis of differentially expressed microRNAs in endometrium to explore the regulation of sheep fecundity

BMC genomics, 2023-10, Vol.24 (1), p.1-600, Article 600

2023

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Effective and Efficient Multi-View Imputation With Optimal Transport

IEEE transactions on knowledge and data engineering, 2024-11, Vol.36 (11), p.6029-6041

2024

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In-orbit geometric calibration of multi-linear array optical remote sensing satellites with tie constraints

Optics express, 2022-07, Vol.30 (15), p.28091-28111

2022

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Blasting effects of the borehole considering decoupled eccentric charge

Alexandria engineering journal, 2024-02, Vol.88, p.116-125

2024

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Evaluate of anti-explosion for high-pressure gas steel pipeline subjected to ground explosion

Journal of constructional steel research, 2021-02, Vol.177, p.106429, Article 106429

2021

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Learning How to Detect Salient Objects in Nighttime Scenes

Journal of scientific & industrial research (New Delhi, India : 1963), 2023-02, Vol.82 (2)

2023

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On the phase stability of MARM247LC alloy during long term thermal exposure

Journal of materials research and technology, 2023-07, Vol.25, p.4479-4487

2023

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Internal Geometric Quality Improvement of Optical Remote Sensing Satellite Images with Image Reorientation

Remote sensing (Basel, Switzerland), 2022-01, Vol.14 (3), p.471

2022

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A new generation Mpro inhibitor with potent activity against SARS-CoV-2 Omicron variants

Discovery and structure-activity relationship studies of 1-aryl-1H-naphtho[2,3-d][1,2,3]triazole-4,9-dione derivatives as potent dual inhibitors of indoleamine 2,3-dioxygenase 1 (IDO1) and trytophan 2,3-dioxygenase (TDO)

Discovery of (S)-3-(4-(benzyloxy)phenyl)-2-(2-phenoxyacetamido)propanoic acid derivatives as a new class of GPR34 antagonists

Discovery of a novel and potent inhibitor with differential species-specific effects against NLRP3 and AIM2 inflammasome-dependent pyroptosis

Targeting Noncanonical Pyroptosis With a Small Molecular Inhibitor Alleviates Inflammation in the LPS-Induced Keratitis Mouse Model

Structural Optimization and Structure-Activity Relationship Studies of 6,6-Dimethyl-4-(phenylamino)-6H-pyrimido[5,4-b][1,4]oxazin-7(8H)-one Derivatives as A New Class of Potent Inhibitors of Pan-Trk and Their Drug-Resistant Mutants

Structural Optimization and Structure-Activity Relationship Studies of 6,6-Dimethyl-4-(phenylamino)-6 H -pyrimido[5,4- b ][1,4]oxazin-7(8 H )-one Derivatives as A New Class of Potent Inhibitors of Pan-Trk and Their Drug-Resistant Mutants

Discovery of a novel pyroptosis inhibitor acting though modulating glutathionylation to suppress NLRP3-related signal pathway

Discovery of a potent and highly selective inhibitor of ataxia telangiectasia mutated and Rad3-Related (ATR) kinase: Structural activity relationship and antitumor activity both in vitro and in vivo

Discovery of 4‑(1,2,4-Oxadiazol-5-yl)azepan-2-one Derivatives as a New Class of Cannabinoid Type 2 Receptor Agonists for the Treatment of Inflammatory Pain

Entropy drives the ligand recognition in G-protein-coupled receptor subtypes

Discovery of small molecule FLT3 inhibitors that are able to overcome drug-resistant mutations

A new generation M pro inhibitor with potent activity against SARS-CoV-2 Omicron variants

Progressive global perception and local polishing network for lung infection segmentation of COVID-19 CT images

An attention residual u-net with differential preprocessing and geometric postprocessing: Learning how to segment vasculature including intracranial aneurysms

An Experimental Investigation on the Dynamic Response of Buried RC Pipes Induced by Falling Impact

Fully Convolutional Network and Visual Saliency-Based Automatic Optic Disc Detection in Retinal Fundus Images

Identification and analysis of differentially expressed microRNAs in endometrium to explore the regulation of sheep fecundity

Effective and Efficient Multi-View Imputation With Optimal Transport

In-orbit geometric calibration of multi-linear array optical remote sensing satellites with tie constraints

Blasting effects of the borehole considering decoupled eccentric charge

Evaluate of anti-explosion for high-pressure gas steel pipeline subjected to ground explosion

Learning How to Detect Salient Objects in Nighttime Scenes

On the phase stability of MARM247LC alloy during long term thermal exposure

Internal Geometric Quality Improvement of Optical Remote Sensing Satellite Images with Image Reorientation

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