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Possibilities and challenges of small molecule organic compounds for the treatment of repeat diseases

Proceedings of the Japan Academy, Series B, 2022/01/11, Vol.98(1), pp.30-48

NAKATANI, Kazuhiko

2022

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Utility of oligonucleotide in upregulating circular RNA production in a cellular model

Scientific reports, 2024-04, Vol.14 (1), p.8096-8096, Article 8096

2024

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Recognition of Mismatched Base Pairs in DNA

Bulletin of the Chemical Society of Japan, 2009-09, Vol.82 (9), p.1055-1069

Nakatani, Kazuhiko

2009

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Bicyclic and tricyclic C-C mismatch-binding ligands bind to CCG trinucleotide repeat DNAs

Chemical communications (Cambridge, England), 2018, Vol.54 (51), p.7074-7077

2018

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Quantitative Microscopic Observation of Base–Ligand Interactions via Hydrogen Bonds by Single-Molecule Counting

Journal of the American Chemical Society, 2023-01, Vol.145 (2), p.1310-1318

2023

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Inhibitory Effects of Mismatch Binding Molecules on the Repair Reaction of Uracil-Containing DNA

Biochemistry (Easton), 2022-11, Vol.61 (22), p.2522-2530

2022

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Small molecule targeting r(UGGAA) n disrupts RNA foci and alleviates disease phenotype in Drosophila model

Nature communications, 2021-01, Vol.12 (1), p.236-13, Article 236

2021

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Mismatch binding ligand upregulated back-splicing reaction producing circular RNA in a cellular model

Chemical communications (Cambridge, England), 2022-03, Vol.58 (22), p.3629-3632

2022

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Molecular Glue for RNA: Regulating RNA Structure and Function through Synthetic RNA Binding Molecules

Chembiochem : a European journal of chemical biology, 2019-12, Vol.20 (23), p.2903-2910

2019

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Modified Nucleic Acids

1, 2016

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Ab initio multi-level layered elongation method and its application to local interaction analysis between DNA bulge and ligand molecules

The Journal of chemical physics, 2021-07, Vol.155 (4), p.044110-044110

2021

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Assembly of ruthenium complexes on double stranded DNA using mismatch binding ligands

Chemical communications (Cambridge, England), 2020-05, Vol.56 (39), p.5227-523

2020

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Recognition of expanded GGGGCC hexanucleotide repeat by synthetic ligand through interhelical binding

Biochemical and biophysical research communications, 2020-10, Vol.531 (1), p.56-61

2020

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NMR determination of the 2:1 binding complex of naphthyridine carbamate dimer (NCD) and CGG/CGG triad in double-stranded DNA

Nucleic acids research, 2022-09, Vol.50 (17), p.9621-9631

2022

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Modulating RNA secondary and tertiary structures by mismatch binding ligands

Methods (San Diego, Calif.), 2019-09, Vol.167, p.78-91

2019

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Restoration of Ribozyme Tertiary Contact and Function by Using a Molecular Glue for RNA

Angewandte Chemie International Edition, 2018-01, Vol.57 (2), p.506-510

International ed. in English, 2018

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Chemical Probing of Thymine in the TGG/CGG Triad to Explore the Deamination of 5‑Methylcytosine in the CGG Repeat

Biochemistry (Easton), 2020-07, Vol.59 (29), p.2679-2683

2020

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Fluorescence Probe for Detecting CCG Trinucleotide Repeat DNA Expansion and Slip-Out

Chembiochem : a European journal of chemical biology, 2016-09, Vol.17 (18), p.1685-1688

2016

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Premature translation termination mediated non-ER stress induced ATF6 activation by a ligand-dependent ribosomal frameshifting circuit

Nucleic acids research, 2022-05, Vol.50 (9), p.5369-5383

2022

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The Dimeric Form of 1,3‐Diaminoisoquinoline Derivative Rescued the Mis‐splicing of Atp2a1 and Clcn1 Genes in Myotonic Dystrophy Type 1 Mouse Model

Chemistry : a European journal, 2020-11, Vol.26 (63), p.14305-14309

2020

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Small synthetic molecule-stabilized RNA pseudoknot as an activator for -1 ribosomal frameshifting

Nucleic acids research, 2018-09, Vol.46 (16), p.8079-8089

2018

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Amphiphilic DNA tiles for controlled insertion and 2D assembly on fluid lipid membranes: the effect on mechanical properties

Nanoscale, 2017-03, Vol.9 (9), p.3051-3058

2017

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CGG repeat DNA assisted dimerization of CGG/CGG binding molecule through intermolecular disulfide formation

Chemical communications (Cambridge, England), 2018-11, Vol.54 (93), p.13072-13075

2018

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Control of DNA hybridization by photoswitchable molecular glue

Chemical Society reviews, 2011-01, Vol.40 (12), p.5718-5729

2011

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Possibilities and challenges of small molecule organic compounds for the treatment of repeat diseases

Utility of oligonucleotide in upregulating circular RNA production in a cellular model

Recognition of Mismatched Base Pairs in DNA

Bicyclic and tricyclic C-C mismatch-binding ligands bind to CCG trinucleotide repeat DNAs

Quantitative Microscopic Observation of Base–Ligand Interactions via Hydrogen Bonds by Single-Molecule Counting

Inhibitory Effects of Mismatch Binding Molecules on the Repair Reaction of Uracil-Containing DNA

Small molecule targeting r(UGGAA) n disrupts RNA foci and alleviates disease phenotype in Drosophila model

Mismatch binding ligand upregulated back-splicing reaction producing circular RNA in a cellular model

Molecular Glue for RNA: Regulating RNA Structure and Function through Synthetic RNA Binding Molecules

Modified Nucleic Acids

Ab initio multi-level layered elongation method and its application to local interaction analysis between DNA bulge and ligand molecules

Assembly of ruthenium complexes on double stranded DNA using mismatch binding ligands

Recognition of expanded GGGGCC hexanucleotide repeat by synthetic ligand through interhelical binding

NMR determination of the 2:1 binding complex of naphthyridine carbamate dimer (NCD) and CGG/CGG triad in double-stranded DNA

Modulating RNA secondary and tertiary structures by mismatch binding ligands

Restoration of Ribozyme Tertiary Contact and Function by Using a Molecular Glue for RNA

Chemical Probing of Thymine in the TGG/CGG Triad to Explore the Deamination of 5‑Methylcytosine in the CGG Repeat

Fluorescence Probe for Detecting CCG Trinucleotide Repeat DNA Expansion and Slip-Out

Premature translation termination mediated non-ER stress induced ATF6 activation by a ligand-dependent ribosomal frameshifting circuit

The Dimeric Form of 1,3‐Diaminoisoquinoline Derivative Rescued the Mis‐splicing of Atp2a1 and Clcn1 Genes in Myotonic Dystrophy Type 1 Mouse Model

Small synthetic molecule-stabilized RNA pseudoknot as an activator for -1 ribosomal frameshifting

Amphiphilic DNA tiles for controlled insertion and 2D assembly on fluid lipid membranes: the effect on mechanical properties

CGG repeat DNA assisted dimerization of CGG/CGG binding molecule through intermolecular disulfide formation

Control of DNA hybridization by photoswitchable molecular glue

FUS regulates RAN translation through modulating the G-quadruplex structure of GGGGCC repeat RNA in C9orf72 -linked ALS/FTD

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