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Sample preparation techniques for radiometabolite analysis of positron emission tomography radioligands; trends, progress, limitations and future prospects

TrAC, Trends in analytical chemistry (Regular ed.), 2019-01, Vol.110, p.1-7

2019

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Determination of plasma protein binding of positron emission tomography radioligands by high-performance frontal analysis

Journal of pharmaceutical and biomedical analysis, 2014-09, Vol.98, p.140-143

2014

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Large Variation in Brain Exposure of Reference CNS Drugs: a PET Study in Nonhuman Primates

The international journal of neuropsychopharmacology, 2015-09, Vol.18 (10), p.pyv036-pyv036

2015

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Identification of PET radiometabolites by cytochrome P450, UHPLC/Q-ToF-MS and fast radio-LC: applied to the PET radioligands [11C]flumazenil, [18F]FE-PE2I, and [11C]PBR28

Analytical and bioanalytical chemistry, 2013-02, Vol.405 (4), p.1303-1310

2013

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Development of two fluorine-18 labeled PET radioligands targeting PDE10A and in vivo PET evaluation in nonhuman primates

Nuclear medicine and biology, 2018-02, Vol.57, p.12-19

2018

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In vivo evaluation of P-glycoprotein function at the blood-brain barrier in nonhuman primates using [11C]verapamil

The Journal of pharmacology and experimental therapeutics, 2006-02, Vol.316 (2), p.647-653

2006

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Development of a series of novel carbon-11 labeled PDE10A inhibitors

Journal of labelled compounds & radiopharmaceuticals, 2015-05, Vol.58 (5), p.202-208

2015

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Discovery and Preclinical Validation of [11C]AZ13153556, a Novel Probe for the Histamine Type 3 Receptor

ACS chemical neuroscience, 2016-02, Vol.7 (2), p.177-184

2016

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Neuroimaging and Physiological Evidence for Involvement of Glutamatergic Transmission in Regulation of the Striatal Dopaminergic System

The Journal of neuroscience, 2009-02, Vol.29 (6), p.1887-1896

2009

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High-yield automated synthesis of [ 18F]fluoroazomycin arabinoside ([ 18F]FAZA) for hypoxia-specific tumor imaging

Applied radiation and isotopes, 2011-07, Vol.69 (7), p.1007-1013

2011

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Combining high-performance liquid chromatography-positron detection and on-line microdialysis for animal metabolism study of positron emission tomography probes

Journal of Chromatography A, 2008-09, Vol.1203 (2), p.193-197

2008

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Improvement of brain uptake for in vivo PET imaging of astrocytic oxidative metabolism using benzyl [1-11C]acetate

Applied radiation and isotopes, 2013-08, Vol.78, p.102-107

2013

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Biodistribution and metabolism of the anti-influenza drug [11 C]oseltamivir and its active metabolite [11 C]Ro 64-0802 in mice

Nuclear medicine and biology, 2009, Vol.36 (1), p.47-55

2009

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1-Minute quality control tests for positron emission tomography radiopharmaceuticals

Journal of pharmaceutical and biomedical analysis, 2009-09, Vol.50 (2), p.245-251

2009

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PET Imaging of VMAT2 with the Novel Radioligand [18F]FE-DTBZ-d4 in Nonhuman Primates: Comparison with [11C]DTBZ and [18F]FE-DTBZ

ACS chemical neuroscience, 2021-12, Vol.12 (24), p.4580-4586

2021

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Cation exchange separation of 61Cu2+ from natCo targets and preparation of 61Cu-DOTA-HSA as a blood pool agent

Applied radiation and isotopes, 2009-04, Vol.67 (4), p.511-515

2009

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“Mixed” anionic and non-ionic micellar liquid chromatography for high-speed radiometabolite analysis of positron emission tomography radioligands

Journal of Chromatography A, 2013-03, Vol.1281, p.54-59

2013

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Improved radiometabolite analysis procedure for positron emission tomography (PET) radioligands using a monolithic column coupled with direct injection micellar/high submicellar liquid chromatography

Talanta (Oxford), 2013-09, Vol.113, p.130-134

2013

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Characterization of [11C]Cimbi-36 as an agonist PET radioligand for the 5-HT2A and 5-HT2C receptors in the nonhuman primate brain

NeuroImage (Orlando, Fla.), 2014-01, Vol.84, p.342-353

2014

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Quantitative PET Analysis of the Dopamine D2 Receptor Agonist Radioligand 11C-(R)-2-CH3O-N-n-Propylnorapomorphine in the Human Brain

The Journal of nuclear medicine (1978), 2009-05, Vol.50 (5), p.703-710

2009

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Direct Plasma Metabolite Analysis of Positron Emission Tomography Radioligands by Micellar Liquid Chromatography with Radiometric Detection

Analytical chemistry (Washington), 2012-04, Vol.84 (7), p.3222-3230

2012

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Positron emission tomography imaging of the 18-kDa translocator protein (TSPO) with [18F]FEMPA in Alzheimer’s disease patients and control subjects

European journal of nuclear medicine and molecular imaging, 2015-03, Vol.42 (3), p.438-446

2015

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Simultaneous Determination of Protein-Free and Total Positron Emission Tomography Radioligand Concentrations in Plasma Using High-Performance Frontal Analysis Followed by Mixed Micellar Liquid Chromatography: Application to [11C]PBR28 in Human Plasma

Analytical chemistry (Washington), 2013-09, Vol.85 (18), p.8728-8734

2013

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Direct Plasma Metabolite Analysis of Positron Emission Tomograpl Radioligands by Micellar Liquid Chromatography with Radiometri Detection

Analytical chemistry (Washington), 2012, Vol.84 (7), p.3222-3230

2012

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Rapid metabolite analysis of positron emission tomography radioligands by direct plasma injection combining micellar cleanup with high submicellar liquid chromatography with radiometric detection

Journal of Chromatography A, 2012-11, Vol.1266, p.76-83

2012

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Sample preparation techniques for radiometabolite analysis of positron emission tomography radioligands; trends, progress, limitations and future prospects

Determination of plasma protein binding of positron emission tomography radioligands by high-performance frontal analysis

Large Variation in Brain Exposure of Reference CNS Drugs: a PET Study in Nonhuman Primates

Identification of PET radiometabolites by cytochrome P450, UHPLC/Q-ToF-MS and fast radio-LC: applied to the PET radioligands [11C]flumazenil, [18F]FE-PE2I, and [11C]PBR28

Development of two fluorine-18 labeled PET radioligands targeting PDE10A and in vivo PET evaluation in nonhuman primates

In vivo evaluation of P-glycoprotein function at the blood-brain barrier in nonhuman primates using [11C]verapamil

Development of a series of novel carbon-11 labeled PDE10A inhibitors

Discovery and Preclinical Validation of [11C]AZ13153556, a Novel Probe for the Histamine Type 3 Receptor

Neuroimaging and Physiological Evidence for Involvement of Glutamatergic Transmission in Regulation of the Striatal Dopaminergic System

High-yield automated synthesis of [ 18F]fluoroazomycin arabinoside ([ 18F]FAZA) for hypoxia-specific tumor imaging

Combining high-performance liquid chromatography-positron detection and on-line microdialysis for animal metabolism study of positron emission tomography probes

Improvement of brain uptake for in vivo PET imaging of astrocytic oxidative metabolism using benzyl [1-11C]acetate

Biodistribution and metabolism of the anti-influenza drug [11 C]oseltamivir and its active metabolite [11 C]Ro 64-0802 in mice

1-Minute quality control tests for positron emission tomography radiopharmaceuticals

PET Imaging of VMAT2 with the Novel Radioligand [18F]FE-DTBZ-d4 in Nonhuman Primates: Comparison with [11C]DTBZ and [18F]FE-DTBZ

Cation exchange separation of 61Cu2+ from natCo targets and preparation of 61Cu-DOTA-HSA as a blood pool agent

“Mixed” anionic and non-ionic micellar liquid chromatography for high-speed radiometabolite analysis of positron emission tomography radioligands

Improved radiometabolite analysis procedure for positron emission tomography (PET) radioligands using a monolithic column coupled with direct injection micellar/high submicellar liquid chromatography

Characterization of [11C]Cimbi-36 as an agonist PET radioligand for the 5-HT2A and 5-HT2C receptors in the nonhuman primate brain

Quantitative PET Analysis of the Dopamine D2 Receptor Agonist Radioligand 11C-(R)-2-CH3O-N-n-Propylnorapomorphine in the Human Brain

Direct Plasma Metabolite Analysis of Positron Emission Tomography Radioligands by Micellar Liquid Chromatography with Radiometric Detection

Positron emission tomography imaging of the 18-kDa translocator protein (TSPO) with [18F]FEMPA in Alzheimer’s disease patients and control subjects

Simultaneous Determination of Protein-Free and Total Positron Emission Tomography Radioligand Concentrations in Plasma Using High-Performance Frontal Analysis Followed by Mixed Micellar Liquid Chromatography: Application to [11C]PBR28 in Human Plasma

Direct Plasma Metabolite Analysis of Positron Emission Tomograpl Radioligands by Micellar Liquid Chromatography with Radiometri Detection

Rapid metabolite analysis of positron emission tomography radioligands by direct plasma injection combining micellar cleanup with high submicellar liquid chromatography with radiometric detection

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