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Estimation of changes in serum creatinine and creatinine clearance caused by renal transporter inhibition in healthy subjects

Drug metabolism and pharmacokinetics, 2019-08, Vol.34 (4), p.233-238

2019

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Comparison of Methods for Estimating Unbound Intracellular-to-Medium Concentration Ratios in Rat and Human Hepatocytes Using Statins

Drug metabolism and disposition, 2017-07, Vol.45 (7), p.779-789

2017

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Prediction of Human Distribution Volumes of Compounds in Various Elimination Phases Using Physiologically Based Pharmacokinetic Modeling and Experimental Pharmacokinetics in Animals

Drug metabolism and disposition, 2019-02, Vol.47 (2), p.114-123

2019

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Quantitative analysis of elevation of serum creatinine via renal transporter inhibition by trimethoprim in healthy subjects using physiologically-based pharmacokinetic model

Drug metabolism and pharmacokinetics, 2018-02, Vol.33 (1), p.103-110

2018

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Insights into drug development with quantitative systems pharmacology: A prospective case study of uncovering hyperkalemia risk in diabetic nephropathy with virtual clinical trials

Drug metabolism and pharmacokinetics, 2024-06, Vol.56, p.101019, Article 101019

2024

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Lung tumorigenesis promoted by anti-apoptotic effects of cotinine, a nicotine metabolite through activation of PI3K/Akt pathway

The Journal of Toxicological Sciences, 2012/06/01, Vol.37(3), pp.555-563

2012

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Prediction of human pharmacokinetics for low‐clearance compounds using pharmacokinetic data from chimeric mice with humanized livers

Clinical and translational science, 2022-01, Vol.15 (1), p.79-91

2022

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Evaluation of the Potency of Telaprevir and Its Metabolites as Inhibitors of Renal Organic Cation Transporters, a Potential Mechanism for the Elevation of Serum Creatinine

DRUG METABOLISM AND PHARMACOKINETICS, 2014, Vol.29 (3), p.266-271

2014

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Systems model identifies baseline cytokine concentrations as potential predictors of rheumatoid arthritis inflammatory response to biologics

British journal of pharmacology, 2022-08, Vol.179 (16), p.4063-4077

2022

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Mechanistic evaluation of the effect of sodium‐dependent glucose transporter 2 inhibitors on delayed glucose absorption in patients with type 2 diabetes mellitus using a quantitative systems pharmacology model of human systemic glucose dynamics

Biopharmaceutics & drug disposition, 2020-11, Vol.41 (8-9), p.352-366

2020

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NMR detection of N-acyliminium ion intermediates generated from .alpha.-alkoxycarbamates

Journal of the American Chemical Society, 1992-01, Vol.114 (1), p.121-125

1992

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Downregulation of dual‐specificity phosphatase 4 enhances cell proliferation and invasiveness in colorectal carcinomas

Cancer science, 2018-01, Vol.109 (1), p.250-258

2018

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DUSP4 is involved in the enhanced proliferation and survival of DUSP4-overexpressing cancer cells

Biochemical and biophysical research communications, 2020-07, Vol.528 (3), p.586-593

2020

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MicroRNA-375 Is Downregulated in Gastric Carcinomas and Regulates Cell Survival by Targeting PDK1 and 14-3-3ζ

Cancer research (Chicago, Ill.), 2010-03, Vol.70 (6), p.2339-2349

2010

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MiR-29c is downregulated in gastric carcinomas and regulates cell proliferation by targeting RCC2

Molecular cancer, 2013-02, Vol.12 (1), p.15-15, Article 15

2013

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Efficient Establishment of Bile-Derived Organoids From Biliary Cancer Patients

Laboratory investigation, 2023-06, Vol.103 (6), p.100105-100105, Article 100105

2023

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Downregulation of WDR20 due to loss of 14q is involved in the malignant transformation of clear cell renal cell carcinoma

Cancer science, 2016-04, Vol.107 (4), p.417-423

2016

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Genomic Loss of DUSP4 Contributes to the Progression of Intraepithelial Neoplasm of Pancreas to Invasive Carcinoma

Cancer research (Chicago, Ill.), 2016-05, Vol.76 (9), p.2612-2625

2016

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Involvement of clusterin expression in the refractory response of pancreatic cancer cells to a MEK inhibitor

Cancer science, 2023-05, Vol.114 (5), p.2189-2202

2023

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Early response in phosphorylation of ribosomal protein S6 is associated with sensitivity to trametinib in colorectal cancer cells

Laboratory investigation, 2021-08, Vol.101 (8), p.1036-1047

2021

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Influence of novel design alteration of pedicle screw on pull-out strength: A finite element study

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 2020-01, Vol.25 (1), p.66-72

2020

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Nano-SiC region formation in (100) Si-on-insulator substrate: Optimization of hot-C+-ion implantation process to improve photoluminescence intensity

Japanese Journal of Applied Physics, 2018-04, Vol.57 (4S), p.4

2018

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Nighttime is associated with decreased survival and resuscitation efforts for out-of-hospital cardiac arrests: a prospective observational study

Critical care (London, England), 2016-05, Vol.20 (1), p.141-141, Article 141

2016

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Genomic profiling of oral squamous cell carcinoma by array-based comparative genomic hybridization

PloS one, 2013-02, Vol.8 (2), p.e56165-e56165

2013

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A transgenic mouse expressing miR‐210 in proximal tubule cells shows mitochondrial alteration: possible association of miR‐210 with a shift in energy metabolism

The Journal of pathology, 2020-05, Vol.251 (1), p.12-25

2020

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Estimation of changes in serum creatinine and creatinine clearance caused by renal transporter inhibition in healthy subjects

Comparison of Methods for Estimating Unbound Intracellular-to-Medium Concentration Ratios in Rat and Human Hepatocytes Using Statins

Prediction of Human Distribution Volumes of Compounds in Various Elimination Phases Using Physiologically Based Pharmacokinetic Modeling and Experimental Pharmacokinetics in Animals

Quantitative analysis of elevation of serum creatinine via renal transporter inhibition by trimethoprim in healthy subjects using physiologically-based pharmacokinetic model

Insights into drug development with quantitative systems pharmacology: A prospective case study of uncovering hyperkalemia risk in diabetic nephropathy with virtual clinical trials

Lung tumorigenesis promoted by anti-apoptotic effects of cotinine, a nicotine metabolite through activation of PI3K/Akt pathway

Prediction of human pharmacokinetics for low‐clearance compounds using pharmacokinetic data from chimeric mice with humanized livers

Evaluation of the Potency of Telaprevir and Its Metabolites as Inhibitors of Renal Organic Cation Transporters, a Potential Mechanism for the Elevation of Serum Creatinine

Systems model identifies baseline cytokine concentrations as potential predictors of rheumatoid arthritis inflammatory response to biologics

Mechanistic evaluation of the effect of sodium‐dependent glucose transporter 2 inhibitors on delayed glucose absorption in patients with type 2 diabetes mellitus using a quantitative systems pharmacology model of human systemic glucose dynamics

NMR detection of N-acyliminium ion intermediates generated from .alpha.-alkoxycarbamates

Downregulation of dual‐specificity phosphatase 4 enhances cell proliferation and invasiveness in colorectal carcinomas

DUSP4 is involved in the enhanced proliferation and survival of DUSP4-overexpressing cancer cells

MicroRNA-375 Is Downregulated in Gastric Carcinomas and Regulates Cell Survival by Targeting PDK1 and 14-3-3ζ

MiR-29c is downregulated in gastric carcinomas and regulates cell proliferation by targeting RCC2

Efficient Establishment of Bile-Derived Organoids From Biliary Cancer Patients

Downregulation of WDR20 due to loss of 14q is involved in the malignant transformation of clear cell renal cell carcinoma

Genomic Loss of DUSP4 Contributes to the Progression of Intraepithelial Neoplasm of Pancreas to Invasive Carcinoma

Involvement of clusterin expression in the refractory response of pancreatic cancer cells to a MEK inhibitor

Early response in phosphorylation of ribosomal protein S6 is associated with sensitivity to trametinib in colorectal cancer cells

Influence of novel design alteration of pedicle screw on pull-out strength: A finite element study

Nano-SiC region formation in (100) Si-on-insulator substrate: Optimization of hot-C+-ion implantation process to improve photoluminescence intensity

Nighttime is associated with decreased survival and resuscitation efforts for out-of-hospital cardiac arrests: a prospective observational study

Genomic profiling of oral squamous cell carcinoma by array-based comparative genomic hybridization

A transgenic mouse expressing miR‐210 in proximal tubule cells shows mitochondrial alteration: possible association of miR‐210 with a shift in energy metabolism

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