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Modulation of cellular S1P levels with a novel, potent and specific inhibitor of sphingosine kinase-1

Biochemical journal, 2012-05, Vol.444 (1), p.79-88

2012

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Modulators of hepatic lipoprotein metabolism identified in a search for small-molecule inducers of tribbles pseudokinase 1 expression

PloS one, 2015-03, Vol.10 (3), p.e0120295

2015

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Discovery of a Potent and Selective Sphingosine Kinase 1 Inhibitor through the Molecular Combination of Chemotype-Distinct Screening Hits

Journal of medicinal chemistry, 2017-03, Vol.60 (6), p.2562-2572

2017

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Molecular Cloning and Functional Characterization of Murine Sphingosine Kinase

The Journal of biological chemistry, 1998-09, Vol.273 (37), p.23722-23728

1998

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The LCB4 (YOR171c) and LCB5(YLR260w) Genes of Saccharomyces Encode Sphingoid Long Chain Base Kinases

The Journal of biological chemistry, 1998-07, Vol.273 (31), p.19437-19442

1998

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Sphingolipid synthesis as a target for antifungal drugs. Complementation of the inositol phosphorylceramide synthase defect in a mutant strain of Saccharomyces cerevisiae by the AUR1 gene

The Journal of biological chemistry, 1997-04, Vol.272 (15), p.9809-9817

1997

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Inhibition of Inositol Phosphorylceramide Synthase by the Cyclic Peptide Aureobasidin A

Antimicrobial Agents and Chemotherapy, 2009-02, Vol.53 (2), p.496-504

2009

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Ceramide/Long-Chain Base Phosphate Rheostat in Saccharomyces cerevisiae: Regulation of Ceramide Synthesis by Elo3p and Cka2p

Eukaryotic Cell, 2003-04, Vol.2 (2), p.284-294

2003

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Analysis of phosphorylated sphingolipid long-chain bases reveals potential roles in heat stress and growth control in Saccharomyces

Journal of Bacteriology, 1999-02, Vol.181 (4), p.1134-1140

1999

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Synthesis of Mannose-(inositol-P)2-ceramide, the Major Sphingolipid in Saccharomyces cerevisiae, Requires the IPT1 (YDR072c) Gene

The Journal of biological chemistry, 1997-11, Vol.272 (47), p.29620-29625

1997

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The LCB2 Gene of Saccharomyces and the Related LCB1 Gene Encode Subunits of Serine Palmitoyltransferase, the Initial Enzyme in Sphingolipid Synthesis

Proceedings of the National Academy of Sciences - PNAS, 1994-08, Vol.91 (17), p.7899-7902

1994

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Macrocyclic Hedgehog Pathway Inhibitors: Optimization of Cellular Activity and Mode of Action Studies

ACS medicinal chemistry letters, 2012-10, Vol.3 (10), p.808-813

2012

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A suppressor gene that enables Saccharomyces cerevisiae to grow without making sphingolipids encodes a protein that resembles an Escherichia coli fatty acyltransferase

The Journal of biological chemistry, 1993-10, Vol.268 (29), p.22156-22163

1993

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A Mammalian Homolog of the Yeast LCB1 Encodes a Component of Serine Palmitoyltransferase, the Enzyme Catalyzing the First Step in Sphingolipid Synthesis

The Journal of biological chemistry, 1997-12, Vol.272 (51), p.32108-32114

1997

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Balancing lysosome abundance in health and disease

Nature cell biology, 2023-09, Vol.25 (9), p.1254-1264

2023

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[1] Serine palmitoyltransferase

Methods in Enzymology, 2000, Vol.311, p.3-9

2000

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UVB irradiation up-regulates serine palmitoyltransferase in cultured human keratinocytes

Journal of lipid research, 1998-10, Vol.39 (10), p.2031-2038

1998

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Inhibition of Amino Acid Transport by Sphingoid Long Chain Bases in Saccharomyces cerevisiae

The Journal of biological chemistry, 1998-01, Vol.273 (5), p.2829-2834

1998

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Rap1-GTPases control mTORC1 activity by coordinating lysosome organization with amino acid availability

Nature communications, 2020-03, Vol.11 (1), p.1416-1416, Article 1416

2020

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Identification of a Saccharomyces Gene,LCB3, Necessary for Incorporation of Exogenous Long Chain Bases into Sphingolipids

The Journal of biological chemistry, 1997-06, Vol.272 (26), p.16110-16117

1997

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Altered propionate metabolism contributes to tumour progression and aggressiveness

Nature metabolism, 2022-04, Vol.4 (4), p.435-443

2022

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Sphingolipid synthesis: Identification and characterization of mammalian cDNAs encoding the Lcb2 subunit of serine palmitoyltransferase

Gene, 1996-10, Vol.177 (1), p.237-241

1996

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Effect of Membrane Perturbants on the Activity and Phase Distribution of Inositol Phosphorylceramide Synthase; Development of a Novel Assay

Biochemistry (Easton), 2004-07, Vol.43 (26), p.8483-8493

2004

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Novel tricyclic glycal-based TRIB1 inducers that reprogram LDL metabolism in hepatic cells

MedChemComm, 2018-11, Vol.9 (11), p.1831-1842

2018

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Yeast sphingolipid bypass mutants as indicators of antifungal agents selectively targeting sphingolipid synthesis

Biochemical and biophysical research communications, 2003-07, Vol.307 (2), p.369-374

2003

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Modulation of cellular S1P levels with a novel, potent and specific inhibitor of sphingosine kinase-1

Modulators of hepatic lipoprotein metabolism identified in a search for small-molecule inducers of tribbles pseudokinase 1 expression

Discovery of a Potent and Selective Sphingosine Kinase 1 Inhibitor through the Molecular Combination of Chemotype-Distinct Screening Hits

Molecular Cloning and Functional Characterization of Murine Sphingosine Kinase

The LCB4 (YOR171c) and LCB5(YLR260w) Genes of Saccharomyces Encode Sphingoid Long Chain Base Kinases

Sphingolipid synthesis as a target for antifungal drugs. Complementation of the inositol phosphorylceramide synthase defect in a mutant strain of Saccharomyces cerevisiae by the AUR1 gene

Inhibition of Inositol Phosphorylceramide Synthase by the Cyclic Peptide Aureobasidin A

Ceramide/Long-Chain Base Phosphate Rheostat in Saccharomyces cerevisiae: Regulation of Ceramide Synthesis by Elo3p and Cka2p

Analysis of phosphorylated sphingolipid long-chain bases reveals potential roles in heat stress and growth control in Saccharomyces

Synthesis of Mannose-(inositol-P)2-ceramide, the Major Sphingolipid in Saccharomyces cerevisiae, Requires the IPT1 (YDR072c) Gene

The LCB2 Gene of Saccharomyces and the Related LCB1 Gene Encode Subunits of Serine Palmitoyltransferase, the Initial Enzyme in Sphingolipid Synthesis

Macrocyclic Hedgehog Pathway Inhibitors: Optimization of Cellular Activity and Mode of Action Studies

A suppressor gene that enables Saccharomyces cerevisiae to grow without making sphingolipids encodes a protein that resembles an Escherichia coli fatty acyltransferase

A Mammalian Homolog of the Yeast LCB1 Encodes a Component of Serine Palmitoyltransferase, the Enzyme Catalyzing the First Step in Sphingolipid Synthesis

Balancing lysosome abundance in health and disease

[1] Serine palmitoyltransferase

UVB irradiation up-regulates serine palmitoyltransferase in cultured human keratinocytes

Inhibition of Amino Acid Transport by Sphingoid Long Chain Bases in Saccharomyces cerevisiae

Rap1-GTPases control mTORC1 activity by coordinating lysosome organization with amino acid availability

Identification of a Saccharomyces Gene,LCB3, Necessary for Incorporation of Exogenous Long Chain Bases into Sphingolipids

Altered propionate metabolism contributes to tumour progression and aggressiveness

Sphingolipid synthesis: Identification and characterization of mammalian cDNAs encoding the Lcb2 subunit of serine palmitoyltransferase

Effect of Membrane Perturbants on the Activity and Phase Distribution of Inositol Phosphorylceramide Synthase; Development of a Novel Assay

Novel tricyclic glycal-based TRIB1 inducers that reprogram LDL metabolism in hepatic cells

Yeast sphingolipid bypass mutants as indicators of antifungal agents selectively targeting sphingolipid synthesis

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