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Acquired resistance to trastuzumab/pertuzumab or to T‐DM1 in vivo can be overcome by HER2 kinase inhibition with TAS0728

Cancer science, 2020-06, Vol.111 (6), p.2123-2131

2020

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Efficacy of Combination Chemotherapy Using a Novel Oral Chemotherapeutic Agent, FTD/TPI, with Ramucirumab Murine Version DC101 in a Mouse Syngeneic Cancer Transplantation Model

Journal of clinical medicine, 2020-12, Vol.9 (12), p.4050

2020

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Evaluation of a Novel Combination Therapy, Based on Trifluridine/Tipiracil and Fruquintinib, against Colorectal Cancer

Chemotherapy (Basel), 2023-06, Vol.68 (2), p.102-110

2023

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ATP-sensitive K + channel in the mitochondrial inner membrane

Nature (London), 1991-07, Vol.352 (6332), p.244-247

1991

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Gene expression analysis using human cancer xenografts to identify novel predictive marker genes for the efficacy of 5‐fluorouracil‐based drugs

Cancer science, 2006-06, Vol.97 (6), p.510-522

2006

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Schlafen11 Expression Is Associated With the Antitumor Activity of Trabectedin in Human Sarcoma Cell Lines

Anticancer research, 2019-07, Vol.39 (7), p.3553-3563

2019

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Antitumor Efficacy of Combination Therapy Consisting of S-1, Leucovorin, and Oxaliplatin against Human Gastric Cancer Xenografts

Chemotherapy (Basel), 2018-01, Vol.63 (1), p.46-52

2018

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Repeated oral dosing of TAS-102 confers high trifluridine incorporation into DNA and sustained antitumor activity in mouse models

Oncology reports, 2014-12, Vol.32 (6), p.2319-2326

2014

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Cell Type-Dependent Divergence of Transactivation by Glucocorticoid Receptor Ligand

Biological and Pharmaceutical Bulletin, 2002, Vol.25(12), pp.1619-1622

2002

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Abstract A126: Acquired resistance to trastuzumab/pertuzumab, or to T-DM1 in vivo can be overcome by HER2 inhibition with TAS0728

Molecular cancer therapeutics, 2019-12, Vol.18 (12_Supplement), p.A126-A126

2019

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Increase in Gene Expression of TYMP, DPYD and HIF1A Are Associated with Response to Preoperative Chemoradiotherapy Including S-1 or UFT for Rectal Cancer

Anticancer research, 2016-05, Vol.36 (5), p.2433-2440

2016

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Induction of CD3+ and FoxP3+ T Cells in Left-sided Colorectal Tumors After UFT/LV Chemotherapy

Anticancer research, 2019-04, Vol.39 (4), p.1997-2005

2019

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Association of right-sided tumors with high thymidine phosphorylase gene expression levels and the response to oral uracil and tegafur/leucovorin chemotherapy among patients with colorectal cancer

Cancer chemotherapy and pharmacology, 2012-08, Vol.70 (2), p.285-291

2012

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Abstract B179: TAS0728, a HER2-selective covalent inhibitor, demonstrates potent antitumor effect as a single agent and in combination with anti-HER2 antibodies in HER2-overexpressed tumor models

Molecular cancer therapeutics, 2018-01, Vol.17 (1_Supplement), p.B179-B179

2018

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Reduction in γ-glutamyl hydrolase expression is associated with response to uracil and tegafur/leucovorin chemotherapy in patients with colorectal cancer

Anticancer research, 2013-08, Vol.33 (8), p.3431-3438

2013

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Expression of Estrogen Receptor Beta and Phosphorylation of Estrogen Receptor Alpha Serine 167 Correlate with Progression-Free Survival in Patients with Metastatic Breast Cancer Treated with Aromatase Inhibitors

Oncology, 2010-01, Vol.79 (1-2), p.55-61

2010

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Abstract C177: TAS-117, a highly selective non-ATP competitive inhibitor of AKT demonstrated antitumor activity in combination with chemotherapeutic agents and molecular targeted drugs

Molecular cancer therapeutics, 2013-11, Vol.12 (11_Supplement), p.C177-C177

2013

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Orotate phosphoribosyltransferase expression level in tumors is a potential determinant of the efficacy of 5-fluorouracil

Biochemical and biophysical research communications, 2007-11, Vol.363 (1), p.216-222

2007

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ATP-sensitive K+ channel in the mitochondrial inner membrane

Nature (London), 1991-07, Vol.352 (6332), p.244-244

1991

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Effect of Depolymerized Holothurian Glycosaminoglycan (DHG) on the Activation of Factor VIII and Factor V by Thrombin

Journal of biochemistry (Tokyo), 1996-01, Vol.119 (1), p.63-69

1996

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Additive antitumor effect of concurrent treatment of 4-hydroxy tamoxifen with 5-fluorouracil but not with doxorubicin in estrogen receptor-positive breast cancer cells

Cancer chemotherapy and pharmacology, 2007-03, Vol.59 (4), p.515-525

2007

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Effect of depolymerized holothurian glycosaminoglycan (DHG) on tissue factor pathway inhibitor: in vitro and in vivo studies

Thrombosis and haemostasis, 1997, Vol.78 (2), p.864-870

1997

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Depolymerized holothurian glycosaminoglycan (DHG), a novel alternative anticoagulant for hemodialysis, is safe and effective in a dog renal failure model

Kidney international, 2003-04, Vol.63 (4), p.1548-1555

2003

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IL-4 and IL-12 Polymorphisms are Associated with Response to Suplatast Tosilate, a Th2 Cytokine Inhibitor, in Patients with Atopic Dermatitis

The open dermatology journal, 2012, Vol.6 (1), p.42-50

Nagase, Hideki

2012

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Hydrogen ion-ATP synthase from rat liver mitochondria. A simple, rapid purification method of the functional complex and its characterization

Biochemistry (Easton), 1991-07, Vol.30 (28), p.6854-6860

1991

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Acquired resistance to trastuzumab/pertuzumab or to T‐DM1 in vivo can be overcome by HER2 kinase inhibition with TAS0728

Efficacy of Combination Chemotherapy Using a Novel Oral Chemotherapeutic Agent, FTD/TPI, with Ramucirumab Murine Version DC101 in a Mouse Syngeneic Cancer Transplantation Model

Evaluation of a Novel Combination Therapy, Based on Trifluridine/Tipiracil and Fruquintinib, against Colorectal Cancer

ATP-sensitive K + channel in the mitochondrial inner membrane

Gene expression analysis using human cancer xenografts to identify novel predictive marker genes for the efficacy of 5‐fluorouracil‐based drugs

Schlafen11 Expression Is Associated With the Antitumor Activity of Trabectedin in Human Sarcoma Cell Lines

Antitumor Efficacy of Combination Therapy Consisting of S-1, Leucovorin, and Oxaliplatin against Human Gastric Cancer Xenografts

Repeated oral dosing of TAS-102 confers high trifluridine incorporation into DNA and sustained antitumor activity in mouse models

Cell Type-Dependent Divergence of Transactivation by Glucocorticoid Receptor Ligand

Abstract A126: Acquired resistance to trastuzumab/pertuzumab, or to T-DM1 in vivo can be overcome by HER2 inhibition with TAS0728

Increase in Gene Expression of TYMP, DPYD and HIF1A Are Associated with Response to Preoperative Chemoradiotherapy Including S-1 or UFT for Rectal Cancer

Induction of CD3+ and FoxP3+ T Cells in Left-sided Colorectal Tumors After UFT/LV Chemotherapy

Association of right-sided tumors with high thymidine phosphorylase gene expression levels and the response to oral uracil and tegafur/leucovorin chemotherapy among patients with colorectal cancer

Abstract B179: TAS0728, a HER2-selective covalent inhibitor, demonstrates potent antitumor effect as a single agent and in combination with anti-HER2 antibodies in HER2-overexpressed tumor models

Reduction in γ-glutamyl hydrolase expression is associated with response to uracil and tegafur/leucovorin chemotherapy in patients with colorectal cancer

Expression of Estrogen Receptor Beta and Phosphorylation of Estrogen Receptor Alpha Serine 167 Correlate with Progression-Free Survival in Patients with Metastatic Breast Cancer Treated with Aromatase Inhibitors

Abstract C177: TAS-117, a highly selective non-ATP competitive inhibitor of AKT demonstrated antitumor activity in combination with chemotherapeutic agents and molecular targeted drugs

Orotate phosphoribosyltransferase expression level in tumors is a potential determinant of the efficacy of 5-fluorouracil

ATP-sensitive K+ channel in the mitochondrial inner membrane

Effect of Depolymerized Holothurian Glycosaminoglycan (DHG) on the Activation of Factor VIII and Factor V by Thrombin

Additive antitumor effect of concurrent treatment of 4-hydroxy tamoxifen with 5-fluorouracil but not with doxorubicin in estrogen receptor-positive breast cancer cells

Effect of depolymerized holothurian glycosaminoglycan (DHG) on tissue factor pathway inhibitor: in vitro and in vivo studies

Depolymerized holothurian glycosaminoglycan (DHG), a novel alternative anticoagulant for hemodialysis, is safe and effective in a dog renal failure model

IL-4 and IL-12 Polymorphisms are Associated with Response to Suplatast Tosilate, a Th2 Cytokine Inhibitor, in Patients with Atopic Dermatitis

Hydrogen ion-ATP synthase from rat liver mitochondria. A simple, rapid purification method of the functional complex and its characterization

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