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Co-regulation of intragenic microRNA miR-153 and its host gene Ia-2β: identification of miR-153 target genes with functions related to IA-2β in pancreas and brain

Diabetologia, 2013-07, Vol.56 (7), p.1547-1556

2013

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Deletion of Ia-2 and/or Ia-2β in mice decreases insulin secretion by reducing the number of dense core vesicles

Diabetologia, 2011-09, Vol.54 (9), p.2347-2357

2011

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The dense core vesicle protein IA-2, but not IA-2β, is required for active avoidance learning

Neuroscience, 2014-06, Vol.269, p.35-42

2014

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Combining quantitative 2D and 3D image analysis in the serial block face SEM: application to secretory organelles of pancreatic islet cells

Journal of microscopy (Oxford), 2015-08, Vol.259 (2), p.155-164

2015

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Autoantigens IA-2 and GAD in Type I (insulin-dependent) diabetes

Diabetologia, 1999, Vol.42 (1), p.3-14

1999

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Determination of secretory granule maturation times in pancreatic islet β-cells by serial block-face electron microscopy

Journal of structural biology, 2020-10, Vol.212 (1), p.107584-107584, Article 107584

2020

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Human chorionic gonadotropin is an immune modulator and can prevent autoimmune diabetes in NOD mice

Diabetologia, 2007-10, Vol.50 (10), p.2147-2155

2007

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Quantitative analysis of mouse pancreatic islet architecture by serial block-face SEM

Journal of structural biology, 2015-01, Vol.189 (1), p.44-52

2015

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The IA-2 interactome

Diabetologia, 2005-12, Vol.48 (12), p.2576-2581

2005

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Immunological heterogeneity in Type I diabetes : presence of distinct autoantibody patterns in patients with acute onset and slowly progressive disease

Diabetologia, 1998-08, Vol.41 (8), p.891-897

1998

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Overexpression of the autoantigen IA-2 puts beta cells into a pre-apoptotic state: autoantigen-induced, but non-autoimmune-mediated, tissue destruction

Clinical and experimental immunology, 2007-10, Vol.150 (1), p.49-60

2007

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Polyreactive antigen‐binding B (PAB+) cells are widely distributed and the PAB+ population consists of both B‐1+ and B‐1– phenotypes

Clinical and experimental immunology, 2004-07, Vol.137 (1), p.88-100

2004

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IA-2, a Transmembrane Protein of the Protein Tyrosine Phosphatase Family, is a Major Autoantigen in Insulin-Dependent Diabetes Mellitus

Proceedings of the National Academy of Sciences - PNAS, 1996-06, Vol.93 (13), p.6367-6370

1996

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The IA-2 gene family : homologs in Caenorhabditis elegans, Drosophila and zebrafish

Diabetologia, 2001-01, Vol.44 (1), p.81-88

2001

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Genomic organization, 5'-upstream sequence, and chromosomal localization of an insulinoma-associated intronless gene, IA-1

The Journal of biological chemistry, 1994-05, Vol.269 (19), p.14170-14174

1994

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Antibodies to IA-2 and GAD65 in type 1 and type 2 diabetes: isotype restriction and polyclonality

Diabetes care, 2000-02, Vol.23 (2), p.228-233

2000

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Polyreactive antibodies in the circulation of patients with systemic lupus erythematosus

Lupus, 2015-12, Vol.24 (14), p.1567-1569

2015

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Probing the Human B-Cell Repertoire with EBV: Polyreactive Antibodies and CD5+ B Lymphocytes

Annual review of immunology, 1989, Vol.7 (1), p.513-535

1989

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Progressive Glomerulosclerosis and Enhanced Renal Accumulation of Basement Membrane Components in Mice Transgenic for Human Immunodeficiency Virus Type 1 Genes

Proceedings of the National Academy of Sciences - PNAS, 1992-03, Vol.89 (5), p.1577-1581

1992

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A novel human insulinoma-associated cDNA, IA-1, encodes a protein with "zinc-finger" DNA-binding motifs

The Journal of biological chemistry, 1992-07, Vol.267 (21), p.15252-15257

1992

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Polyreactive antibodies and polyreactive antigen-binding B (PAB) Cells

Current topics in microbiology and immunology, 2000, Vol.252, p.241

Notkins, A L

2000

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HIV-associated nephropathy in transgenic mice expressing HIV-1 genes

Virology (New York, N.Y.), 1991-11, Vol.185 (1), p.109-119

1991

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Molecular determinants of polyreactive antibody binding: HCDR3 and cyclic peptides

Clinical and experimental immunology, 2000-01, Vol.119 (1), p.69-76

2000

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Human monoclonal rheumatoid factor-like antibodies from CD5 (Leu-1)+ B cells are polyreactive

The Journal of immunology (1950), 1988-06, Vol.140 (12), p.4180

1988

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The relationship between humoral and cellular immunity to IA-2 in IDDM

Diabetes (New York, N.Y.), 1998-04, Vol.47 (4), p.566

1998

Volltextzugriff (PDF)

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Co-regulation of intragenic microRNA miR-153 and its host gene Ia-2β: identification of miR-153 target genes with functions related to IA-2β in pancreas and brain

Deletion of Ia-2 and/or Ia-2β in mice decreases insulin secretion by reducing the number of dense core vesicles

The dense core vesicle protein IA-2, but not IA-2β, is required for active avoidance learning

Combining quantitative 2D and 3D image analysis in the serial block face SEM: application to secretory organelles of pancreatic islet cells

Autoantigens IA-2 and GAD in Type I (insulin-dependent) diabetes

Determination of secretory granule maturation times in pancreatic islet β-cells by serial block-face electron microscopy

Human chorionic gonadotropin is an immune modulator and can prevent autoimmune diabetes in NOD mice

Quantitative analysis of mouse pancreatic islet architecture by serial block-face SEM

The IA-2 interactome

Immunological heterogeneity in Type I diabetes : presence of distinct autoantibody patterns in patients with acute onset and slowly progressive disease

Overexpression of the autoantigen IA-2 puts beta cells into a pre-apoptotic state: autoantigen-induced, but non-autoimmune-mediated, tissue destruction

Polyreactive antigen‐binding B (PAB+) cells are widely distributed and the PAB+ population consists of both B‐1+ and B‐1– phenotypes

IA-2, a Transmembrane Protein of the Protein Tyrosine Phosphatase Family, is a Major Autoantigen in Insulin-Dependent Diabetes Mellitus

The IA-2 gene family : homologs in Caenorhabditis elegans, Drosophila and zebrafish

Genomic organization, 5'-upstream sequence, and chromosomal localization of an insulinoma-associated intronless gene, IA-1

Antibodies to IA-2 and GAD65 in type 1 and type 2 diabetes: isotype restriction and polyclonality

Polyreactive antibodies in the circulation of patients with systemic lupus erythematosus

Probing the Human B-Cell Repertoire with EBV: Polyreactive Antibodies and CD5+ B Lymphocytes

Progressive Glomerulosclerosis and Enhanced Renal Accumulation of Basement Membrane Components in Mice Transgenic for Human Immunodeficiency Virus Type 1 Genes

A novel human insulinoma-associated cDNA, IA-1, encodes a protein with "zinc-finger" DNA-binding motifs

Polyreactive antibodies and polyreactive antigen-binding B (PAB) Cells

HIV-associated nephropathy in transgenic mice expressing HIV-1 genes

Molecular determinants of polyreactive antibody binding: HCDR3 and cyclic peptides

Human monoclonal rheumatoid factor-like antibodies from CD5 (Leu-1)+ B cells are polyreactive

The relationship between humoral and cellular immunity to IA-2 in IDDM

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