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Drug Induced Liver Injury (DILI). Mechanisms and Medicinal Chemistry Avoidance/Mitigation Strategies

Journal of medicinal chemistry, 2020-10, Vol.63 (20), p.11397-11419

Norman, Bryan H

2020

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Exploring the known chemical space of the plant kingdom: insights into taxonomic patterns, knowledge gaps, and bioactive regions

Journal of cheminformatics, 2023-11, Vol.15 (1), p.107-107, Article 107

2023

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Novel Autotaxin Inhibitors for the Treatment of Osteoarthritis Pain: Lead Optimization via Structure-Based Drug Design

ACS medicinal chemistry letters, 2016-09, Vol.7 (9), p.857-861

2016

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Identification of potent and selective retinoic acid receptor gamma (RARγ) antagonists for the treatment of osteoarthritis pain using structure based drug design

Bioorganic & medicinal chemistry letters, 2016-07, Vol.26 (14), p.3274-3277

2016

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Targeting the Nerve Growth Factor (NGF) Pathway in Drug Discovery. Potential Applications to New Therapies for Chronic Pain

Journal of medicinal chemistry, 2017-01, Vol.60 (1), p.66-88

2017

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Identification and Mitigation of Reactive Metabolites of 2‑Aminoimidazole-Containing Microsomal Prostaglandin E Synthase‑1 Inhibitors Terminated Due to Clinical Drug-Induced Liver Injury

Journal of medicinal chemistry, 2018-03, Vol.61 (5), p.2041-2051

2018

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Structure-based, multi-targeted drug discovery approach to eicosanoid inhibition: Dual inhibitors of mPGES-1 and 5-lipoxygenase activating protein (FLAP)

Biochimica et biophysica acta. General subjects, 2021-02, Vol.1865 (2), p.129800-129800, Article 129800

2021

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Discovery and Characterization of 2‑Acylaminoimidazole Microsomal Prostaglandin E Synthase‑1 Inhibitors

Journal of medicinal chemistry, 2016-01, Vol.59 (1), p.194-205

2016

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Pharmacological Characterization of a Potent Inhibitor of Autotaxin in Animal Models of Inflammatory Bowel Disease and Multiple Sclerosis

The Journal of pharmacology and experimental therapeutics, 2016-10, Vol.359 (1), p.207-214

2016

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Identification and Characterization of Novel Microsomal Prostaglandin E Synthase-1 Inhibitors for Analgesia

The Journal of pharmacology and experimental therapeutics, 2016-03, Vol.356 (3), p.635-644

2016

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Discovery and characterization of [(cyclopentyl)ethyl]benzoic acid inhibitors of microsomal prostaglandin E synthase-1

Bioorganic & medicinal chemistry letters, 2017-03, Vol.27 (6), p.1478-1483

2017

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Characterization of 3,3-dimethyl substituted N-aryl piperidines as potent microsomal prostaglandin E synthase-1 inhibitors

Bioorganic & medicinal chemistry letters, 2016-10, Vol.26 (19), p.4824-4828

2016

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Benzopyrans Are Selective Estrogen Receptor β Agonists with Novel Activity in Models of Benign Prostatic Hyperplasia

Journal of medicinal chemistry, 2006-10, Vol.49 (21), p.6155-6157

2006

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Studies on the Mechanism of Phosphatidylinositol 3-Kinase Inhibition by Wortmannin and Related Analogs

Journal of medicinal chemistry, 1996-03, Vol.39 (5), p.1106-1111

1996

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Benzopyrans as selective estrogen receptor β agonists (SERBAs). Part 5: Combined A- and C-ring structure–activity relationship studies

Bioorganic & medicinal chemistry letters, 2007-10, Vol.17 (20), p.5563-5566

2007

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Benzopyrans as selective estrogen receptor β agonists (SERBAs). Part 3: Synthesis of cyclopentanone and cyclohexanone intermediates for C-ring modification

Bioorganic & medicinal chemistry letters, 2007-09, Vol.17 (17), p.4824-4828

2007

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Benzopyrans as selective estrogen receptor β agonists (SERBAs). Part 4: Functionalization of the benzopyran A-ring

Bioorganic & medicinal chemistry letters, 2007-09, Vol.17 (18), p.5082-5085

2007

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Alkylation Studies of N-Protected-5-substituted Morpholin-3-ones. A Stereoselective Approach to Novel Methylene Ether Dipeptide Isosteres

Journal of organic chemistry, 1996-07, Vol.61 (15), p.4990-4998

1996

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Benzopyrans as selective estrogen receptor β agonists (SERBAs). Part 2: Structure–activity relationship studies on the benzopyran scaffold

Bioorganic & medicinal chemistry letters, 2007-07, Vol.17 (13), p.3570-3574

2007

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Cyclohexyl-linked tricyclic isoxazoles are potent and selective modulators of the multidrug resistance protein (MRP1)

Bioorganic & medicinal chemistry letters, 2005-12, Vol.15 (24), p.5526-5530

2005

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Chemoenzymatic and Ring E-Modular Approach to the (−)-Podophyllotoxin Skeleton. Synthesis of 3‘,4‘,5‘-Tridemethoxy-(−)-podophyllotoxin

Journal of the American Chemical Society, 1996-10, Vol.118 (39), p.9426-9427

1996

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Synthesis of Constrained Raloxifene Analogues by Complementary Use of Friedel−Crafts and Directed Remote Metalation Reactions

Journal of organic chemistry, 2003-07, Vol.68 (15), p.5992-5999

2003

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Synthesis of Cryptophycin 52 Using the Shi Epoxidation

Organic letters, 2002-05, Vol.4 (10), p.1813-1815

2002

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Tricyclic isoxazoles are novel inhibitors of the multidrug resistance protein (MRP1)

Bioorganic & medicinal chemistry letters, 2002-03, Vol.12 (6), p.883-886

2002

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(Nitroaryl)sulfinyl-substituted allenes. Novel and convenient propargyl alcohol synthons in 4 + 2 cycloaddition chemistry

Journal of organic chemistry, 1991-06, Vol.56 (13), p.4252-4259

1991

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Drug Induced Liver Injury (DILI). Mechanisms and Medicinal Chemistry Avoidance/Mitigation Strategies

Exploring the known chemical space of the plant kingdom: insights into taxonomic patterns, knowledge gaps, and bioactive regions

Novel Autotaxin Inhibitors for the Treatment of Osteoarthritis Pain: Lead Optimization via Structure-Based Drug Design

Identification of potent and selective retinoic acid receptor gamma (RARγ) antagonists for the treatment of osteoarthritis pain using structure based drug design

Targeting the Nerve Growth Factor (NGF) Pathway in Drug Discovery. Potential Applications to New Therapies for Chronic Pain

Identification and Mitigation of Reactive Metabolites of 2‑Aminoimidazole-Containing Microsomal Prostaglandin E Synthase‑1 Inhibitors Terminated Due to Clinical Drug-Induced Liver Injury

Structure-based, multi-targeted drug discovery approach to eicosanoid inhibition: Dual inhibitors of mPGES-1 and 5-lipoxygenase activating protein (FLAP)

Discovery and Characterization of 2‑Acylaminoimidazole Microsomal Prostaglandin E Synthase‑1 Inhibitors

Pharmacological Characterization of a Potent Inhibitor of Autotaxin in Animal Models of Inflammatory Bowel Disease and Multiple Sclerosis

Identification and Characterization of Novel Microsomal Prostaglandin E Synthase-1 Inhibitors for Analgesia

Discovery and characterization of [(cyclopentyl)ethyl]benzoic acid inhibitors of microsomal prostaglandin E synthase-1

Characterization of 3,3-dimethyl substituted N-aryl piperidines as potent microsomal prostaglandin E synthase-1 inhibitors

Benzopyrans Are Selective Estrogen Receptor β Agonists with Novel Activity in Models of Benign Prostatic Hyperplasia

Studies on the Mechanism of Phosphatidylinositol 3-Kinase Inhibition by Wortmannin and Related Analogs

Benzopyrans as selective estrogen receptor β agonists (SERBAs). Part 5: Combined A- and C-ring structure–activity relationship studies

Benzopyrans as selective estrogen receptor β agonists (SERBAs). Part 3: Synthesis of cyclopentanone and cyclohexanone intermediates for C-ring modification

Benzopyrans as selective estrogen receptor β agonists (SERBAs). Part 4: Functionalization of the benzopyran A-ring

Alkylation Studies of N-Protected-5-substituted Morpholin-3-ones. A Stereoselective Approach to Novel Methylene Ether Dipeptide Isosteres

Benzopyrans as selective estrogen receptor β agonists (SERBAs). Part 2: Structure–activity relationship studies on the benzopyran scaffold

Cyclohexyl-linked tricyclic isoxazoles are potent and selective modulators of the multidrug resistance protein (MRP1)

Chemoenzymatic and Ring E-Modular Approach to the (−)-Podophyllotoxin Skeleton. Synthesis of 3‘,4‘,5‘-Tridemethoxy-(−)-podophyllotoxin

Synthesis of Constrained Raloxifene Analogues by Complementary Use of Friedel−Crafts and Directed Remote Metalation Reactions

Synthesis of Cryptophycin 52 Using the Shi Epoxidation

Tricyclic isoxazoles are novel inhibitors of the multidrug resistance protein (MRP1)

(Nitroaryl)sulfinyl-substituted allenes. Novel and convenient propargyl alcohol synthons in 4 + 2 cycloaddition chemistry

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