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The cellular thermal shift assay for evaluating drug target interactions in cells

Nature protocols, 2014-09, Vol.9 (9), p.2100-2122

2014

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Understanding transport by the major facilitator superfamily (MFS): structures pave the way

Nature reviews. Molecular cell biology, 2016-02, Vol.17 (2), p.123

2016

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The Cellular Thermal Shift Assay: A Novel Biophysical Assay for In Situ Drug Target Engagement and Mechanistic Biomarker Studies

Annual review of pharmacology and toxicology, 2016-01, Vol.56 (1), p.141-161

2016

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Ribonucleotide reductases

Annual review of biochemistry, 2006-01, Vol.75 (1), p.681-706

2006

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Thermal proximity coaggregation for system-wide profiling of protein complex dynamics in cells

Science (American Association for the Advancement of Science), 2018-03, Vol.359 (6380), p.1170-1177

2018

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Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay

Science (American Association for the Advancement of Science), 2013-07, Vol.341 (6141), p.84-87

2013

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Identifying purine nucleoside phosphorylase as the target of quinine using cellular thermal shift assay

Science translational medicine, 2019-01, Vol.11 (473)

2019

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CETSA in integrated proteomics studies of cellular processes

Current opinion in chemical biology, 2020-02, Vol.54, p.54-62

2020

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Modulation of Protein-Interaction States through the Cell Cycle

Cell, 2018-05, Vol.173 (6), p.1481-1494.e13

2018

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CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil

Nature communications, 2016-03, Vol.7 (1), p.11040-11040, Article 11040

2016

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Cellular thermal shift assay for the identification of drug-target interactions in the Plasmodium falciparum proteome

Nature protocols, 2020-06, Vol.15 (6), p.1881-1921

2020

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Tracking cancer drugs in living cells by thermal profiling of the proteome

Science (American Association for the Advancement of Science), 2014-10, Vol.346 (6205), p.55-55

2014

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Thermofluor-based high-throughput stability optimization of proteins for structural studies

Analytical biochemistry, 2006-10, Vol.357 (2), p.289-298

2006

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Structural basis for substrate transport in the GLUT-homology family of monosaccharide transporters

Nature structural & molecular biology, 2013-06, Vol.20 (6), p.766

2013

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Selectivity mechanism of a bacterial homolog of the human drug-peptide transporters PepT1 and PepT2

Nature structural & molecular biology, 2014-08, Vol.21 (8), p.728

2014

Volltextzugriff (PDF)

Structural analyses of human thymidylate synthase reveal a site that may control conformational switching between active and inactive states

The Journal of biological chemistry, 2017-08, Vol.292 (32), p.13449-13458

2017

Volltextzugriff (PDF)

Crystal Structure of a Divalent Metal Ion Transporter CorA at 2.9 Angstrom Resolution

Science (American Association for the Advancement of Science), 2006-07, Vol.313 (5785), p.354-357

2006

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Dual blockade of the lipid kinase PIP4Ks and mitotic pathways leads to cancer-selective lethality

Nature communications, 2017-12, Vol.8 (1), p.2200-13, Article 2200

2017

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A saposin-lipoprotein nanoparticle system for membrane proteins

Nature methods, 2016-04, Vol.13 (4), p.345

2016

Volltextzugriff (PDF)

Chemical Screening Methods to Identify Ligands That Promote Protein Stability, Protein Crystallization, and Structure Determination

Proceedings of the National Academy of Sciences - PNAS, 2006-10, Vol.103 (43), p.15835-15840

2006

Volltextzugriff (PDF)

An efficient proteome-wide strategy for discovery and characterization of cellular nucleotide-protein interactions

PloS one, 2018-12, Vol.13 (12), p.e0208273-e0208273

2018

Volltextzugriff (PDF)

Target identification and validation of natural products with label-free methodology: A critical review from 2005 to 2020

Pharmacology & therapeutics (Oxford), 2020-12, Vol.216, p.107690-107690, Article 107690

2020

Volltextzugriff (PDF)

Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization

Nature structural & molecular biology, 2011-03, Vol.18 (3), p.316

2011

Volltextzugriff (PDF)

Engineering protein thermostability using a generic activity-independent biophysical screen inside the cell

Nature communications, 2013-12, Vol.4 (1), p.2901, Article 2901

2013

Volltextzugriff (PDF)

Structural Basis for Phosphoinositide Substrate Recognition, Catalysis, and Membrane Interactions in Human Inositol Polyphosphate 5-Phosphatases

Structure (London), 2014-05, Vol.22 (5), p.744-755

2014

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The cellular thermal shift assay for evaluating drug target interactions in cells

Understanding transport by the major facilitator superfamily (MFS): structures pave the way

The Cellular Thermal Shift Assay: A Novel Biophysical Assay for In Situ Drug Target Engagement and Mechanistic Biomarker Studies

Ribonucleotide reductases

Thermal proximity coaggregation for system-wide profiling of protein complex dynamics in cells

Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay

Identifying purine nucleoside phosphorylase as the target of quinine using cellular thermal shift assay

CETSA in integrated proteomics studies of cellular processes

Modulation of Protein-Interaction States through the Cell Cycle

CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil

Cellular thermal shift assay for the identification of drug-target interactions in the Plasmodium falciparum proteome

Tracking cancer drugs in living cells by thermal profiling of the proteome

Thermofluor-based high-throughput stability optimization of proteins for structural studies

Structural basis for substrate transport in the GLUT-homology family of monosaccharide transporters

Selectivity mechanism of a bacterial homolog of the human drug-peptide transporters PepT1 and PepT2

Structural analyses of human thymidylate synthase reveal a site that may control conformational switching between active and inactive states

Crystal Structure of a Divalent Metal Ion Transporter CorA at 2.9 Angstrom Resolution

Dual blockade of the lipid kinase PIP4Ks and mitotic pathways leads to cancer-selective lethality

A saposin-lipoprotein nanoparticle system for membrane proteins

Chemical Screening Methods to Identify Ligands That Promote Protein Stability, Protein Crystallization, and Structure Determination

An efficient proteome-wide strategy for discovery and characterization of cellular nucleotide-protein interactions

Target identification and validation of natural products with label-free methodology: A critical review from 2005 to 2020

Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization

Engineering protein thermostability using a generic activity-independent biophysical screen inside the cell

Structural Basis for Phosphoinositide Substrate Recognition, Catalysis, and Membrane Interactions in Human Inositol Polyphosphate 5-Phosphatases

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