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Physicochemical Properties, Form, and Formulation Selection Strategy for a Biopharmaceutical Classification System Class II Preclinical Drug Candidate

Journal of pharmaceutical sciences, 2014-10, Vol.103 (10), p.3007-3021

2014

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Analysis of the absorption kinetics of macromolecules following intradermal and subcutaneous administration

European journal of pharmaceutics and biopharmaceutics, 2015-01, Vol.89, p.134-144

2015

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The nature and regulation of the receptors for insulin-like growth factors

Annual review of physiology, 1985-01, Vol.47 (1), p.425-442

1985

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Insulin-like growth factors maintain steady-state metabolism of proteoglycans in bovine articular cartilage explants

Archives of biochemistry and biophysics, 1988-12, Vol.267 (2), p.416-425

1988

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Evidence for the direct interaction of the insulin-like growth factor I receptor with IRS-1, Shc, and Grb10

Molecular endocrinology (Baltimore, Md.), 1996-06, Vol.10 (6), p.631-641

1996

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Inhibition of the Biologic Response to Insulin-like Growth Factor I in MCF-7 Breast Cancer Cells by a New Monoclonal Antibody to the Insulin-like Growth Factor-I Receptor. The Importance of Receptor Down-regulation

Hormone and metabolic research, 2003-11, Vol.35 (11/12), p.850-856

2003

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An antibody that blocks insulin-like growth factor (IGF) binding to the type II IGF receptor is neither an agonist nor an inhibitor of IGF-stimulated biologic responses in L6 myoblasts

The Journal of biological chemistry, 1987-09, Vol.262 (26), p.12745-12751

1987

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Knock your SOCS off

The Journal of clinical investigation, 2005-02, Vol.115 (2), p.233-236

2005

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Biochemical evidence that the type II insulin-like growth factor receptor is identical to the cation-independent mannose 6-phosphate receptor

The Journal of biological chemistry, 1988-07, Vol.263 (19), p.9339-9344

1988

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Developmental regulation of insulin-like growth factor II mRNA in different rat tissues

The Journal of biological chemistry, 1986-10, Vol.261 (28), p.13144-13150

1986

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Developmental expression of the tissue insulin-like growth factor II/mannose 6-phosphate receptor in the rat. Measurement by quantitative immunoblotting

The Journal of biological chemistry, 1989-10, Vol.264 (28), p.16733-16738

1989

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Type II Insulin-Like Growth Factor Receptor is Present in Rat Serum

Proceedings of the National Academy of Sciences - PNAS, 1987-11, Vol.84 (21), p.7720-7724

1987

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Insulin-like growth factor-II (IGF-II) inhibits both the cellular uptake of β-galactosidase and the binding of β-galactosidase to purified IGF-II/mannose 6-phosphate receptor

The Journal of biological chemistry, 1989-03, Vol.264 (8), p.4710-4714

1989

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Interaction of Human Suppressor of Cytokine Signaling (SOCS)-2 with the Insulin-like Growth Factor-I Receptor

The Journal of biological chemistry, 1998-09, Vol.273 (37), p.24095-24101

1998

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Characterization of insulin-like growth factor I-stimulated tyrosine kinase activity associated with the beta-subunit of type I insulin-like growth factor receptors of rat liver cells

The Journal of biological chemistry, 1985-08, Vol.260 (17), p.9793-9804

1985

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Insulin-Like Growth Factor Receptors

Growth factors (Chur, Switzerland), 1991, Vol.5 (1), p.29-43

1991

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Suppressor of Cytokine Signaling (SOCS)-3 Protein Interacts with the Insulin-like Growth Factor-I Receptor

Biochemical and biophysical research communications, 2000-11, Vol.278 (1), p.38-43

2000

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Activation of Extracellular Signal-Regulated Kinases 1 and 2 by Insulin-Like Growth Factor I in Human Osteosarcoma MG-63 Cells

Hormone and metabolic research, 1999, Vol.31 (2/03), p.65-69

1999

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Developmental patterns of insulin-like growth factor-I and -II synthesis and regulation in rat fibroblasts

Nature (London), 1983-03, Vol.302 (5904), p.150-152

1983

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Increased Levels of Multiplication-Stimulating Activity, an Insulin-Like Growth Factor, in Fetal Rat Serum

Proceedings of the National Academy of Sciences - PNAS, 1980-06, Vol.77 (6), p.3649-3653

1980

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14-3-3 proteins interact with the insulin-like growth factor receptor but not the insulin receptor

Biochemical journal, 1997-11, Vol.327 ( Pt 3) (Pt 3), p.765-771

1997

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Pertussis toxin sensitive G-proteins are not involved in the mitogenic signaling pathway of insulin-like growth factor-I in normal rat kidney epithelial (NRKE) cells

Regulatory peptides, 1996-04, Vol.62 (2), p.65-71

1996

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Structure, specificity, and regulation of the insulin-like growth factor-binding proteins in adult rat serum

Endocrinology (Philadelphia), 1989-09, Vol.125 (3), p.1540-1555

1989

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Direct demonstration of separate receptors for growth and metabolic activities of insulin and multiplication-stimulating activity (an insulinlike growth factor) using antibodies to the insulin receptor

The Journal of clinical investigation, 1980-07, Vol.66 (1), p.130-140

1980

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Modulation of insulinlike growth factor I binding to human fibroblast monolayer cultures by insulinlike. Growth factor carrier proteins released to the incubation media

The Journal of clinical investigation, 1986-02, Vol.77 (2), p.602-613

1986

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Physicochemical Properties, Form, and Formulation Selection Strategy for a Biopharmaceutical Classification System Class II Preclinical Drug Candidate

Analysis of the absorption kinetics of macromolecules following intradermal and subcutaneous administration

The nature and regulation of the receptors for insulin-like growth factors

Insulin-like growth factors maintain steady-state metabolism of proteoglycans in bovine articular cartilage explants

Evidence for the direct interaction of the insulin-like growth factor I receptor with IRS-1, Shc, and Grb10

Inhibition of the Biologic Response to Insulin-like Growth Factor I in MCF-7 Breast Cancer Cells by a New Monoclonal Antibody to the Insulin-like Growth Factor-I Receptor. The Importance of Receptor Down-regulation

An antibody that blocks insulin-like growth factor (IGF) binding to the type II IGF receptor is neither an agonist nor an inhibitor of IGF-stimulated biologic responses in L6 myoblasts

Knock your SOCS off

Biochemical evidence that the type II insulin-like growth factor receptor is identical to the cation-independent mannose 6-phosphate receptor

Developmental regulation of insulin-like growth factor II mRNA in different rat tissues

Developmental expression of the tissue insulin-like growth factor II/mannose 6-phosphate receptor in the rat. Measurement by quantitative immunoblotting

Type II Insulin-Like Growth Factor Receptor is Present in Rat Serum

Insulin-like growth factor-II (IGF-II) inhibits both the cellular uptake of β-galactosidase and the binding of β-galactosidase to purified IGF-II/mannose 6-phosphate receptor

Interaction of Human Suppressor of Cytokine Signaling (SOCS)-2 with the Insulin-like Growth Factor-I Receptor

Characterization of insulin-like growth factor I-stimulated tyrosine kinase activity associated with the beta-subunit of type I insulin-like growth factor receptors of rat liver cells

Insulin-Like Growth Factor Receptors

Suppressor of Cytokine Signaling (SOCS)-3 Protein Interacts with the Insulin-like Growth Factor-I Receptor

Activation of Extracellular Signal-Regulated Kinases 1 and 2 by Insulin-Like Growth Factor I in Human Osteosarcoma MG-63 Cells

Developmental patterns of insulin-like growth factor-I and -II synthesis and regulation in rat fibroblasts

Increased Levels of Multiplication-Stimulating Activity, an Insulin-Like Growth Factor, in Fetal Rat Serum

14-3-3 proteins interact with the insulin-like growth factor receptor but not the insulin receptor

Pertussis toxin sensitive G-proteins are not involved in the mitogenic signaling pathway of insulin-like growth factor-I in normal rat kidney epithelial (NRKE) cells

Structure, specificity, and regulation of the insulin-like growth factor-binding proteins in adult rat serum

Direct demonstration of separate receptors for growth and metabolic activities of insulin and multiplication-stimulating activity (an insulinlike growth factor) using antibodies to the insulin receptor

Modulation of insulinlike growth factor I binding to human fibroblast monolayer cultures by insulinlike. Growth factor carrier proteins released to the incubation media

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