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High-Throughput Screening and Characterization of Reactive Metabolites Using Polarity Switching of Hybrid Triple Quadrupole Linear Ion Trap Mass Spectrometry

Analytical chemistry (Washington), 2008-03, Vol.80 (5), p.1788-1799

2008

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Mechanism-based inactivation of cytochrome P450 3A4 by lapatinib

Molecular pharmacology, 2010-10, Vol.78 (4), p.693-703

2010

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Comparative metabonomic analysis of hepatotoxicity induced by acetaminophen and its less toxic meta-isomer

Archives of toxicology, 2016-12, Vol.90 (12), p.3073-3085

2016

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An inducible cytochrome P450 3A4-dependent vitamin D catabolic pathway

Molecular pharmacology, 2012-04, Vol.81 (4), p.498-509

2012

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The Structural Basis for Homotropic and Heterotropic Cooperativity of Midazolam Metabolism by Human Cytochrome P450 3A4

Biochemistry (Easton), 2011-12, Vol.50 (50), p.10804-10818

2011

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Rearrangement reactions catalyzed by cytochrome P450s

Archives of biochemistry and biophysics, 2011-03, Vol.507 (1), p.95-110

2011

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Metabolic intermediate complex formation of human cytochrome P450 3A4 by lapatinib

Drug metabolism and disposition, 2011-06, Vol.39 (6), p.1022-1030

2011

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Acetaminophen-induced liver damage in mice is associated with gender-specific adduction of peroxiredoxin-6

Redox biology, 2014-01, Vol.2 (C), p.377-387

2014

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Metabolism and Toxicity of Menthofuran in Rat Liver Slices and in Rats

Chemical research in toxicology, 2010-11, Vol.23 (11), p.1824-1832

2010

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The use of deuterium isotope effects to probe the active site properties, mechanism of cytochrome P450-catalyzed reactions, and mechanisms of metabolically dependent toxicity

Drug metabolism and disposition, 2003-12, Vol.31 (12), p.1481-1497

2003

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Proteomic Analysis of Acetaminophen-Induced Changes in Mitochondrial Protein Expression Using Spectral Counting

Chemical research in toxicology, 2011-04, Vol.24 (4), p.549-558

2011

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Inhibition of Macrophage Migration Inhibitory Factor (MIF) Tautomerase and Biological Activities by Acetaminophen Metabolites

Proceedings of the National Academy of Sciences - PNAS, 2002-01, Vol.99 (1), p.144-149

2002

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Identification of the Interactions between Cytochrome P450 2E1 and Cytochrome b5 by Mass Spectrometry and Site-directed Mutagenesis

The Journal of biological chemistry, 2006-07, Vol.281 (29), p.20404-20417

2006

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Cooperative Binding of Acetaminophen and Caffeine within the P450 3A4 Active Site

Chemical research in toxicology, 2007-10, Vol.20 (10), p.1434-1441

2007

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Studies on the role of metabolic activation in tyrosine kinase inhibitor-dependent hepatotoxicity: induction of CYP3A4 enhances the cytotoxicity of lapatinib in HepaRG cells

Drug metabolism and disposition, 2014-01, Vol.42 (1), p.162-171

2014

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Nrf2 Activation Involves an Oxidative-Stress Independent Pathway in Tetrafluoroethylcysteine-Induced Cytotoxicity

Toxicological sciences, 2005-08, Vol.86 (2), p.354-364

2005

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Profiling the hepatic effects of flutamide in rats: a microarray comparison with classical aryl hydrocarbon receptor ligands and atypical CYP1A inducers

Drug metabolism and disposition, 2006-07, Vol.34 (7), p.1266-1275

2006

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Involvement of human cytochrome P450 2D6 in the bioactivation of acetaminophen

Drug metabolism and disposition, 2000-12, Vol.28 (12), p.1397

2000

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p53 Contributes to Differentiating Gene Expression Following Exposure to Acetaminophen and Its Less Hepatotoxic Regioisomer Both In Vitro and In Vivo

Gene Regulation and Systems Biology, 2015-01, Vol.2015 (9), p.1-14

2015

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Oxidation of Acetaminophen to Its Toxic Quinone Imine and Nontoxic Catechol Metabolites by Baculovirus-Expressed and Purified Human Cytochromes P450 2E1 and 2A6

Chemical research in toxicology, 1998-04, Vol.11 (4), p.295-301

1998

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Differential Oxidation of Two Thiophene-Containing Regioisomers to Reactive Metabolites by Cytochrome P450 2C9

Chemical research in toxicology, 2012-04, Vol.25 (4), p.895-903

2012

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Interaction of lapatinib with cytochrome P450 3A5

Drug metabolism and disposition, 2012-07, Vol.40 (7), p.1414-1422

2012

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Oxidation of caffeine by CYP1A2: isotope effects and metabolic switching

Drug metabolism and disposition, 2005-12, Vol.33 (12), p.1837

2005

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Fluorescent Photoaffinity Labeling of Cytochrome P450 3A4 by Lapachenole: Identification of Modification Sites by Mass Spectrometry

Biochemistry (Easton), 2005-02, Vol.44 (6), p.1833-1845

2005

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Cross-Linking Mass Spectrometry and Mutagenesis Confirm the Functional Importance of Surface Interactions between CYP3A4 and Holo/Apo Cytochrome b 5

Biochemistry (Easton), 2012-11, Vol.51 (47), p.9488-9500

2012

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High-Throughput Screening and Characterization of Reactive Metabolites Using Polarity Switching of Hybrid Triple Quadrupole Linear Ion Trap Mass Spectrometry

Mechanism-based inactivation of cytochrome P450 3A4 by lapatinib

Comparative metabonomic analysis of hepatotoxicity induced by acetaminophen and its less toxic meta-isomer

An inducible cytochrome P450 3A4-dependent vitamin D catabolic pathway

The Structural Basis for Homotropic and Heterotropic Cooperativity of Midazolam Metabolism by Human Cytochrome P450 3A4

Rearrangement reactions catalyzed by cytochrome P450s

Metabolic intermediate complex formation of human cytochrome P450 3A4 by lapatinib

Acetaminophen-induced liver damage in mice is associated with gender-specific adduction of peroxiredoxin-6

Metabolism and Toxicity of Menthofuran in Rat Liver Slices and in Rats

The use of deuterium isotope effects to probe the active site properties, mechanism of cytochrome P450-catalyzed reactions, and mechanisms of metabolically dependent toxicity

Proteomic Analysis of Acetaminophen-Induced Changes in Mitochondrial Protein Expression Using Spectral Counting

Inhibition of Macrophage Migration Inhibitory Factor (MIF) Tautomerase and Biological Activities by Acetaminophen Metabolites

Identification of the Interactions between Cytochrome P450 2E1 and Cytochrome b5 by Mass Spectrometry and Site-directed Mutagenesis

Cooperative Binding of Acetaminophen and Caffeine within the P450 3A4 Active Site

Studies on the role of metabolic activation in tyrosine kinase inhibitor-dependent hepatotoxicity: induction of CYP3A4 enhances the cytotoxicity of lapatinib in HepaRG cells

Nrf2 Activation Involves an Oxidative-Stress Independent Pathway in Tetrafluoroethylcysteine-Induced Cytotoxicity

Profiling the hepatic effects of flutamide in rats: a microarray comparison with classical aryl hydrocarbon receptor ligands and atypical CYP1A inducers

Involvement of human cytochrome P450 2D6 in the bioactivation of acetaminophen

p53 Contributes to Differentiating Gene Expression Following Exposure to Acetaminophen and Its Less Hepatotoxic Regioisomer Both In Vitro and In Vivo

Oxidation of Acetaminophen to Its Toxic Quinone Imine and Nontoxic Catechol Metabolites by Baculovirus-Expressed and Purified Human Cytochromes P450 2E1 and 2A6

Differential Oxidation of Two Thiophene-Containing Regioisomers to Reactive Metabolites by Cytochrome P450 2C9

Interaction of lapatinib with cytochrome P450 3A5

Oxidation of caffeine by CYP1A2: isotope effects and metabolic switching

Fluorescent Photoaffinity Labeling of Cytochrome P450 3A4 by Lapachenole: Identification of Modification Sites by Mass Spectrometry

Cross-Linking Mass Spectrometry and Mutagenesis Confirm the Functional Importance of Surface Interactions between CYP3A4 and Holo/Apo Cytochrome b 5

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