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A mouse Fcγ-Fcϵ protein that inhibits mast cells through activation of FcγRIIB, SH2 domain–containing inositol phosphatase 1, and SH2 domain–containing protein tyrosine phosphatases

Journal of allergy and clinical immunology, 2008, Vol.121 (2), p.441-447.e5

2008

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Homeostasis and anergy of CD4 + CD25 + suppressor T cells in vivo

Nature immunology, 2002-01, Vol.3 (1), p.33-41

2002

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Discovery of structural diverse reversible BTK inhibitors utilized to develop a novel in vivo CD69 and CD86 PK/PD mouse model

Bioorganic & medicinal chemistry letters, 2023-01, Vol.80, p.129108, Article 129108

2023

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Optimization of novel reversible Bruton’s tyrosine kinase inhibitors identified using Tethering-fragment-based screens

Bioorganic & medicinal chemistry, 2019-07, Vol.27 (13), p.2905-2913

2019

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Utilizing structure based drug design and metabolic soft spot identification to optimize the in vitro potency and in vivo pharmacokinetic properties leading to the discovery of novel reversible Bruton’s tyrosine kinase inhibitors

Bioorganic & medicinal chemistry, 2021-08, Vol.44, p.116275-116275, Article 116275

2021

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Systemic administration of an Fcγ–Fcε-fusion protein in house dust mite sensitive nonhuman primates

Clinical immunology (Orlando, Fla.), 2008-09, Vol.128 (3), p.340-348

2008

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Changes in the distribution of LFA-1, catenins, and F-actin during transendothelial migration of monocytes in culture

Journal of cell science, 1997-11, Vol.110 ( Pt 22) (22), p.2807-2818

1997

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Cytoskeletal disruption induces T cell apoptosis by a caspase-3 mediated mechanism

Life sciences (1973), 1999-11, Vol.65 (25), p.2697-2707

1999

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Mechanisms of allergy and clinical immunology: A mouse Fc gamma -Fc epsilon protein that inhibits mast cells through activation of Fc gamma RIIB, SH2 domain-containing inositol phosphatase 1, and SH2 domain-containing protein tyrosine phosphatases

Journal of allergy and clinical immunology, 2008-02, Vol.121 (2), p.441-447.e5

2008

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A mouse Fc[gamma]-Fc[epsilon] protein that inhibits mast cells through activation of Fc[gamma]RIIB, SH2 domain-containing inositol phosphatase 1, and SH2 domain-containing protein tyrosine phosphatases

Journal of allergy and clinical immunology, 2008-02, Vol.121 (2), p.441

2008

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A mouse Fcγ-Fc∈ protein that inhibits mast cells through activation of FcγRIIB, SH2 domain-containing inositol phosphatase 1, and SH2 domain-containing protein tyrosine phosphatases

Journal of allergy and clinical immunology, 2008, Vol.121 (2), p.441-447

2008

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Homeostasis and anergy of [CD4.sup.+][CD25.sup.+] suppressor T cells in vivo

Nature immunology, 2002-01, Vol.3 (1), p.33

2002

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Homeostasis and anergy of CD4 super(+) CD25 super(+) suppressor T cells in vivo

Nature immunology, 2002-01, Vol.3 (1), p.33-41

2002

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Systemic administration of an Fcgamma-Fc(epsilon)-fusion protein in house dust mite sensitive nonhuman primates

Clinical immunology (Orlando, Fla.), 2008-09, Vol.128 (3), p.340-348

2008

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A mouse Fcgamma-Fcepsilon protein that inhibits mast cells through activation of FcgammaRIIB, SH2 domain-containing inositol phosphatase 1, and SH2 domain-containing protein tyrosine phosphatases

Journal of allergy and clinical immunology, 2008-02, Vol.121 (2), p.441-447.e5

2008

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Transendothelial Migration of Monocytes in Rat Aorta: Distribution of F-actin, α-Catenin, LFA-1, and PECAM-1

Biotechnic & histochemistry, 1999, Vol.74 (6), p.276-293

1999

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A mouse Fcγ-Fcϵ protein that inhibits mast cells through activation of FcγRIIB, SH2 domain–containing inositol phosphatase 1, and SH2 domain–containing protein tyrosine phosphatases

Homeostasis and anergy of CD4 + CD25 + suppressor T cells in vivo

Discovery of structural diverse reversible BTK inhibitors utilized to develop a novel in vivo CD69 and CD86 PK/PD mouse model

Optimization of novel reversible Bruton’s tyrosine kinase inhibitors identified using Tethering-fragment-based screens

Utilizing structure based drug design and metabolic soft spot identification to optimize the in vitro potency and in vivo pharmacokinetic properties leading to the discovery of novel reversible Bruton’s tyrosine kinase inhibitors

Systemic administration of an Fcγ–Fcε-fusion protein in house dust mite sensitive nonhuman primates

Changes in the distribution of LFA-1, catenins, and F-actin during transendothelial migration of monocytes in culture

Cytoskeletal disruption induces T cell apoptosis by a caspase-3 mediated mechanism

Mechanisms of allergy and clinical immunology: A mouse Fc gamma -Fc epsilon protein that inhibits mast cells through activation of Fc gamma RIIB, SH2 domain-containing inositol phosphatase 1, and SH2 domain-containing protein tyrosine phosphatases

A mouse Fc[gamma]-Fc[epsilon] protein that inhibits mast cells through activation of Fc[gamma]RIIB, SH2 domain-containing inositol phosphatase 1, and SH2 domain-containing protein tyrosine phosphatases

A mouse Fcγ-Fc∈ protein that inhibits mast cells through activation of FcγRIIB, SH2 domain-containing inositol phosphatase 1, and SH2 domain-containing protein tyrosine phosphatases

Homeostasis and anergy of [CD4.sup.+][CD25.sup.+] suppressor T cells in vivo

Homeostasis and anergy of CD4 super(+) CD25 super(+) suppressor T cells in vivo

Systemic administration of an Fcgamma-Fc(epsilon)-fusion protein in house dust mite sensitive nonhuman primates

A mouse Fcgamma-Fcepsilon protein that inhibits mast cells through activation of FcgammaRIIB, SH2 domain-containing inositol phosphatase 1, and SH2 domain-containing protein tyrosine phosphatases

Transendothelial Migration of Monocytes in Rat Aorta: Distribution of F-actin, α-Catenin, LFA-1, and PECAM-1

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